Background and Aim: Coping ways with stress in coronary heart disease patients can lead to significant changes in the levels of biomarkers IL- 1 β and cortisol. Thus, the aim of the present study was to examine the relationship between coping ways with stress and level of IL- 1 β and cortisol in coronary heart disease patients.

  Materials and Methods: The statistical population covered all patients with CHD who referred to Tehran Shahid Rajaie Heart Hospital. 44 patients with CHD admitted to different wards of the hospital were selected as eligible cases.In the present, Lazarus and Folkman questionnaires and Human IL- 1 β kits manufactured by Austrian Bender Med System Manufacturing Co and cortisol kits ( made by IBL Manufacturing Co., Germany),employing ELISA method of measurement ,were used.

  Results: It was found that there was a significant positive correlation between emotional focused coping ways with biomarkers IL - 1 β and cortisol .But, a significant negative correlation was observed between problem focused coping ways and biomarkers IL-1 β and cortisol .Moreover, between 8 ways of coping with stress only predictive positive re-evaluation had a significant relationship with IL-1 β and Cortisol.

  Conclusion: An increase in the use of problem focused coping ways including positive re-evaluation way can reduce levels of IL- 1 β and cortisol.