Volume 30, Issue 3 (December 2023)
J Birjand Univ Med Sci. 2023, 30(3): 268-279 |
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Research code: IR.KMU.REC.1399.688
Ethics code: IR.KMU.REC.1399.688
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Pirani H, Salehi O, Khoramipour K, Golestaneh F. The effect of eight weeks of high-intensity interval training on changes in the levels of leptin, adiponectin and insulin levels in male Wistar rats. J Birjand Univ Med Sci. 2023; 30 (3) :268-279
URL: http://journal.bums.ac.ir/article-1-3266-en.html
URL: http://journal.bums.ac.ir/article-1-3266-en.html
1- Department of Faculty Member of Chabahar Maritime University, Chabahar, Iran , hn.piranis@gmail.com
2- Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran
3- Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Physiology Research Center and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4- Department of Faculty Member of Chabahar Maritime University, Chabahar, Iran
2- Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran
3- Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Physiology Research Center and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4- Department of Faculty Member of Chabahar Maritime University, Chabahar, Iran
Abstract: (317 Views)
Background and Aims: Obesity leads to impaired secretion and expression of adipokines in humans and causes the onset of type 2 diabetes. Although the role of regular exercise in the prevention of metabolic diseases has been reported, the mechanism of high-intensity exercise is still not well understood. Therefore, the aim of the present study was to investigate the effects of 8 weeks of high-intensity interval training on the changes in insulin, leptin and adiponectin levels in male Wistar rats with type 2 diabetes.
Materials and Methods: In this experimental study 20 male Wistar rats aged 8-10 weeks were randomly divided into four groups: Control, type 2 diabetes, exercise, and diabetes-exercise. Type 2 diabetes was induced by a high-fat diet and a single dose of streptozotocin (STZ). The rats in the exercise and diabetes-exercise groups completed 8 weeks of HIIT training (running at an intensity of 85-95% of maximum speed, intervals of 4-10). Insulin, adiponectin and leptin levels were measured in serum. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), the Homeostasis Model Assessment for Insulin Resistance-beta (HOMA-β) and the Quantitative Assessment of Insulin Sensitivity Index (QUICKI) were calculated to assess insulin resistance and sensitivity.
Results: Diabetes decreased the level of insulin, adiponectin and leptin in serum. HIIT reversed the impairments caused by diabetes. HOMA-IR, HOMA-β and QUICKI also improved in the diabetes-exercise groups.
Conclusion: Overall, our results confirmed that diabetes has detrimental effects on serum leptin, adiponectin and insulin indices and that HIIT training can improve these disorders.
*Corresponding Author: Hossein Pirani; Emails: hn.piranis@gmail.com
Materials and Methods: In this experimental study 20 male Wistar rats aged 8-10 weeks were randomly divided into four groups: Control, type 2 diabetes, exercise, and diabetes-exercise. Type 2 diabetes was induced by a high-fat diet and a single dose of streptozotocin (STZ). The rats in the exercise and diabetes-exercise groups completed 8 weeks of HIIT training (running at an intensity of 85-95% of maximum speed, intervals of 4-10). Insulin, adiponectin and leptin levels were measured in serum. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), the Homeostasis Model Assessment for Insulin Resistance-beta (HOMA-β) and the Quantitative Assessment of Insulin Sensitivity Index (QUICKI) were calculated to assess insulin resistance and sensitivity.
Results: Diabetes decreased the level of insulin, adiponectin and leptin in serum. HIIT reversed the impairments caused by diabetes. HOMA-IR, HOMA-β and QUICKI also improved in the diabetes-exercise groups.
Conclusion: Overall, our results confirmed that diabetes has detrimental effects on serum leptin, adiponectin and insulin indices and that HIIT training can improve these disorders.
*Corresponding Author: Hossein Pirani; Emails: hn.piranis@gmail.com
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Type of Study: Original Article |
Subject:
Exercise Physiology
Received: 2023/04/25 | Accepted: 2023/12/23 | ePublished ahead of print: 2023/12/22 | ePublished: 2023/12/24
Received: 2023/04/25 | Accepted: 2023/12/23 | ePublished ahead of print: 2023/12/22 | ePublished: 2023/12/24
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