Volume 25, Issue 3 (October 2018)
J Birjand Univ Med Sci. 2018, 25(3): 203-212 |
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Khorsandi K, Hosseinzadeh R, Khatibi Shahidi F, Chamani E. Comparison on Anticancer Effects of phenolic Compounds, Gallic Acid and Para Coumaric Acid on Human Breast Cancer Cells. J Birjand Univ Med Sci. 2018; 25 (3) :203-212
URL: http://journal.bums.ac.ir/article-1-2486-en.html
URL: http://journal.bums.ac.ir/article-1-2486-en.html
1- Photodynamic Research Group, Medical Laser Research Center, Tehran, ACECR, Iran. , biochem.kh@gmail.com
2- Laser in Medicine Research Group, Medical Laser Research Center, Tehran, ACECR, Iran.
3- Photodynamic Research Group, Medical Laser Research Center, Tehran, ACECR, Iran.
4- Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2- Laser in Medicine Research Group, Medical Laser Research Center, Tehran, ACECR, Iran.
3- Photodynamic Research Group, Medical Laser Research Center, Tehran, ACECR, Iran.
4- Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Abstract: (8595 Views)
Background and Aim: Phenolic compounds form an important category of antioxidants that have important biological activities, such as anticancer, antifungal, antibacterial and antiviral effects. In this study, the anticancer effects of Gallic acid and P-Coumaric acid were studied on MDA-MB-231 human breast cancer cell line.
Materials and Methods: In this experimental study, human breast cancer cells of MDA-MB-231 (104 cells) were treated with Gallic acid, P-Coumaric Acid in different concentrations (0, 10, 25, 50 and 100 μg / ml) for 24 hours. The cell viability of treated cells was determined using MTT assay and invert light microscopy.
Results: The cell viability of treated cell with 100 μg/ml Gallic cell is about 16%, and in the case of para-coumaric acid at the similar concentration, the cell viability is about 83%. The morphological study confirmed the results of MTT using an inverted light microscope.
Conclusion: The inhibitory effect of Gallic acid in MDA-MB-231 human breast cancer cells is higher in comparison to P-Coumaric acid at the similar concentration. According to the study, this effect could be due to the difference in the number of hydroxyl groups on these compounds.
Materials and Methods: In this experimental study, human breast cancer cells of MDA-MB-231 (104 cells) were treated with Gallic acid, P-Coumaric Acid in different concentrations (0, 10, 25, 50 and 100 μg / ml) for 24 hours. The cell viability of treated cells was determined using MTT assay and invert light microscopy.
Results: The cell viability of treated cell with 100 μg/ml Gallic cell is about 16%, and in the case of para-coumaric acid at the similar concentration, the cell viability is about 83%. The morphological study confirmed the results of MTT using an inverted light microscope.
Conclusion: The inhibitory effect of Gallic acid in MDA-MB-231 human breast cancer cells is higher in comparison to P-Coumaric acid at the similar concentration. According to the study, this effect could be due to the difference in the number of hydroxyl groups on these compounds.
Keywords: Phenolic Compounds, Gallic Acid, Para-Coumaric Acid, Human Breast Cancer Cells, Cell Viability
Type of Study: Original Article |
Subject:
Pharmacology- Medicinal plants
Received: 2018/05/5 | Accepted: 2018/06/12 | ePublished ahead of print: 2018/10/7 | ePublished: 2018/10/7
Received: 2018/05/5 | Accepted: 2018/06/12 | ePublished ahead of print: 2018/10/7 | ePublished: 2018/10/7
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