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Background and Aim: Invasive diarrhea is a self-limited disease but its antibiotic treatment not only reduces the disease marking time, but also excretion of the microbes and, consequently, a decrease in the pathogenicity of the disease. The present study was conducted to compare patients' resistance to ciprofloxacin and to azithromycin in non-amoebic acute dysenteric. Materials and Methods: In this clinical- trial study 84 patients suffering from non-amoebic dysentery were selected through successive sampling, and were randomly divided into two groups. One group was administered Ciprofloxacin 500mg every 12 hours, the other group Azitromycin 250mg daily (every 24 hours). Then patients examined after 48 hours to see the probable improvement of their previous clinical symptoms. Besides, their first day feces culture was assessed. The obtained data was fed into SPSS software (V: 1/3), and then it was analysed using X2 statistical test at the significant level α=0.05.for afebrility and decreased diarrhea .data analyzed in using test. Results: Out of 84 patients, shigella was diagnosed in 41 (48.8%), 18 patients of whom (43.9%) had been treated with azitromycin and 23 cases (56.1%) had received ciprofloxacin .In 14 samples (16.7%) other microbes had grown (e.g. Salmonella, Campylobacter jejuni, Escherichia Coli). Antibiogram of 55 patients showed that 32 (58.2%) of them were sensitive to ciprofloxacin and 41 subjects (74.5%) to azitromycin .On the third day of treatment the clinical response of the patients was assessed through their probable fever and diarrhea .It was found that 29 cases (93.5%) in azitromycin group and 31 patients (88.5%) in ciprofloxacin group were a febrile. Thus, no significant difference between the two groups was observed (P=0.6). Conclusion: The present study proved that Azitromycin and Ciprofloxacin have the same efficacy in treating non-amoebic dysentery

Keywords: Non amoebic dysentery, Ciprofloxacin, Azithromycin

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