Volume 19, Issue 2 (July 2012)                   J Birjand Univ Med Sci. 2012, 19(2): 132-139 | Back to browse issues page

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Keshavarzi F, Nankali A, Rezaei M, Taravat F, Jalilian N, Mohammadi N, et al . Comparison of Extra-Amniotic Normal Saline Infusion plus Hydrocortisone versus Prostaglandin E2 Suppository for Pregnancy Termination. J Birjand Univ Med Sci.. 2012; 19 (2) :132-139
URL: http://journal.bums.ac.ir/article-1-778-en.html
1- Kermanshah University of Medical Sciences
2- Assistant Professor of Obstetrics & Gynecology, Maternity Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences (KUMS), Iran , anis_nankali@yahoo.com
Abstract:   (18689 Views)

  Background and Aim: Pregnancy termination before onset of labor is one of the midwifery problems. The aim of the present study was to compare extra-amniotic normal saline infusion plus hydrocortisone effect versus prostaglandin E2 suppository for cervical ripening and second- trimester pregnancy termination.

  Materials and Methods: This randomized clinical-trial study was performed on 50 pregnant women with gestation age of 14 to 28 weeks and Bishops Score ≤ 2 who required pregnancy termination for fetal indications. Half of the cases received extra-amniotic normal saline infusion plus 100 mg hydrocortisone (EASI+ H) and the other half received two doses of 3mg prostaglandin E2 suppository every 4 hours. Six hours later, induction of labor was started by means of a high dose of Oxytocin according to of Alabama University Protocol for Mid-trimester Abortion. The obtained data was analyzed by using statistical softwares Chi-square, Fisher and T-test.

  Results: There were no differences between the two groups regarding maternal age, parity, gestational age, Primary Bishops Score and indication of pregnancy termination. In the EASI+H group, the mean interval between initiation of labor induction and fetal expulsion was 23.04 ± 4.47 hours and in PGE2 group was 28.65 ± 2.87 hours (P=0.001). The success rate in the EASI+H group was 100% and in PGE2 group 80 %
(P =0.04). Complications such as fever, nausea, vomiting, diarrhea, increase of blood pressure and need to curettage in PGE2 group were statistically and significantly more abundant.

  Conclusion: Extra-amniotic normal saline infusion plus hydrocortisone is an effective and safe method that is suggested for cervical ripening and second- trimester pregnancy termination.  

Full-Text [PDF 211 kb]   (2954 Downloads)    
Type of Study: Original Article | Subject: Gynecology & Obstetrics
Received: 2011/01/21 | Accepted: 2014/03/5 | Published: 2014/03/5

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