Volume 21, Number 4 (January 2015)                   J Birjand Univ Med Sci. 2015, 21(4): 444-450 | Back to browse issues page


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Salehi M, Hashemi Karoi M, Nasrollahi omran A, Mobini M, Asghar Hedari M. Antifungal activity of in vitro aqueous and alcoholic extracts of Barije root (Ferula gummosa) . J Birjand Univ Med Sci.. 2015; 21 (4) :444-450
URL: http://journal.bums.ac.ir/article-1-1677-en.html

1- MSc in Biology, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran. , mohammadsalehi73@gmail.com
2- Assistant professor, Department of Biology, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.
3- Associate professor, Department of Biology, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.
4- MSc in Biology, Young researchers club, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
Abstract:   (4915 Views)
Background and Aim: Ferula gummosa Boiss. (Barije) is an Iranian indigenous plant that has medical and antifungal properties. The current study was done to determine the effect of aqueous an alcoholic extracts of Ferula gummosa Boiss root on in vitro growth of fungi. Materials and Methods: In this experimental study, the plant was dried in the dark and aqueous, alcoholic extracts of its root powder were prepared using Soxhlet method. Then, the efficacy of 0.1 dilutions of different quantities of the extracts on strains of Candida albicans (PTCC 5027), Trichophyton rubrum (PTCC5143), and Aspergillus fumigatus (PTCC 5009) were evaluated employing Disk diffusion, Agar-well diffusion, Minimum Inhibitory Concentration (MIC), and Minimum Fungicidal Concentration (MFC) methods. Results: No inhibited effect was observed in Disk diffusion and Agar-well diffusion methods. MIC and MFC values of all extracts for Aspergillus fumigatus and Trichophyton rubrum were more than 5×104mg/ml. The MIC values of ethanol and methanol extract for Candida albicans were 3.12×103 and 1.25×104mg/ml, respectively but the MFC values were 1.25×104 and 2.5×104mg/ml, respectively. Conclusion: Methanol and ethanol extracts proved to have antifungal activity against Candida albicans yeast in vitro while the fungi of Aspergillus fumigatus and Trichophyton rubrum had no sensitivity to these types of extracts.
Keywords: Ferula gummosa, Fungi, MIC, MFC
Full-Text [PDF 244 kb]   (1822 Downloads)    
Type of Study: Original Article | Subject: Microbiology
Received: 2014/07/10 | Accepted: 2015/01/19 | Published: 2015/02/4

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