Volume 18, Issue 4 (January 2011)                   Journal of Scientific Research in Medical Sciences. 2011, 18(4): 275-284 | Back to browse issues page

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Salimi Z, Heidari R, Nejati V, Eskandary A, Ghasemi Z. Effect of Sumac (Rhus coriaria L.) extract on lipid peroxidation and diabetic nephropathy in diabetic rats. Journals of Birjand University of Medical Sciences 2011; 18 (4) :275-284
URL: http://journal.bums.ac.ir/article-1-704-en.html
Effect of Sumac (Rhus coriaria L.) extract on lipid peroxidation and diabetic nephropathy in diabetic rats
Z Salimi * 1, R Heidari2 , V Nejati3 , A Eskandary4 , Z Ghasemi5
1- MA Animal Physiology, Department of Biology, Faculty of Science, Urmia University, Iran , Zahra.salimi.bio@gmail.com
2- Faculty of Science, University of Urmia, Iran
3- Department of Biology, Faculty of Science, University of Urmia, Iran
4- Department of Biology, Faculty of Science, Urmia University, Iran
5- Department of Statistics, Faculty of Science, Razi University, Iran
Abstract:   (85695 Views)
Background and Aim: Reactive oxygen species (ROS) and oxidative stress play important roles in the development of diabetic complications. Regarding the importance of medicinal herbs, the effect of Sumac extract on lipid peroxidation and diabetic nephropathy was explored in this study. Materials and Methods: In this experimental study, 30 adult male Wistar rats were divided into 5 six member groups. Control rats were injected with the necessary volume of physiological serum. Group II contracted diabetes by being intraperitoneally injected 120 mg/kg Alloxan.The rats of the third, fourth , and fifth group , in addition to the same treatment, were fed 50, 100 and 250 mg/kg of aqueous extract of Rhus-coriaria L. respectively for 4 weeks. After 28 days of treatment, blood samples were collected from the heart. Plasma malondialdehyde (MDA) concentration, as an end product of lipid peroxidation, was determined. In addition, kidney tissues were removed and prepared for histological analysis. The obtained data was analyzed by means of one-way analysis of variance (ANOVA) and Tukey statistical test Results: Treatment with the extract of Sumac caused a significant reduction in MDA level in diabetic groups treated, compared with the control and diabetic groups (P<0.05). Moreover, treatment with the extract led also to a significant improvement of side-effects of diabetes mellitus on the distal arterioles of renal tissues in diabetic rats. Conclusion: It was found that sumac decreases lipid peroxidation and kidney damage in diabetic rats.
Keywords: Sumac (Rhus coriaria L.), Nephropathy, Diabetes, Lipid, Peroxidation
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Type of Study: Original Article | Subject: Traditional medicine and Complementary Medicine
Received: 2010/10/3 | Accepted: 2011/06/15 | ePublished: 2016/03/10
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