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Amooeian S, Taiebi-Meibodi N, Farzadnia M, Omidvar-Tehrani D. A case report of liver Involvement during adult T-cell leukemia / lymphoma. J Birjand Univ Med Sci. 2005; 12 (1 and 2) :9-15
URL: http://journal.bums.ac.ir/article-1-51-en.html

T-cell leukemia virus type 1 (HTLV-1) is the first known human retrovirus which belongs to oncovirus family. The virus has limited geographical prevalence and the north of Khorasan is one of the areas with endemic virus (2.3-3%). Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of the activated CD4+ T lymphocytes and is only found in patients belonging to areas where retrovirus HTLV-1 is an endemic infection. Regarding the rare prevalence of ATLL in the infected people (2%-4%) and also the rare involvement of the liver during its course and the fact that it may wrongly be taken as other liverinvolved diseases, a case of liver-involvement during ATLL is reported here. A 55 year old man with positive HTLV1 and involvement of liver during ATLL, who was admitted due to suffering from fever, anxiety, abdominal fullness, and anorexia. By means of sonography several hypoechoic foci were found the in liver. On microscopic examination of liver mass sample, infiltrations of large polymorphic lymphoid cells within sinusoids were seen. In immunohistochemistry with immunoperoxidase modality, CD45 RO (Tlymphocyte marker) was positive and CD20 (B lymphocyte marker) was negative. In PCR, we observed Tax and Env genes related to HTLV-1 in the tumoral cells of liver tissue.