Cardiometabolic aging: A vicious cycle that must be broken: Editorial Article

kazemi, toba

Volume 32 - Supplementary Journal of Translational Medical Research. 2026, 32 - Supplementary: 0-0 | Back to browse issues page

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kazemi T. Cardiometabolic aging: A vicious cycle that must be broken: Editorial Article. Journal of Translational Medical Research. 2026; 32 (0)
URL: http://journal.bums.ac.ir/article-1-3582-en.html

Cardiometabolic aging: A vicious cycle that must be broken: Editorial Article

Toba Kazemi ^*

, drtooba.kazemi@gmail.com

Abstract: (13 Views)

Cardiometabolic aging is an emerging concept that describes a bidirectional interaction between metabolic disorders and biological aging processes. Evidences indicate that insulin resistance, central obesity, and dyslipidemia are not merely consequences of aging but they are active drivers of accelerated cellular aging. These metabolic disturbances promote a vicious cycle through the amplification of systemic chronic inflammation, oxidative stress, mitochondrial dysfunction, and adverse alterations in gut microbiota composition. These mechanisms accelerate biological aging, contribute to multimorbidity, and increase the risk of atherosclerotic cardiovascular diseases. This cycle is further intensified by unhealthy lifestyle, genetic and epigenetic susceptibility, and social health inequalities, making cardiometabolic aging a major contributor to the global burden of non‑communicable diseases (NCD). Breaking this cycle requires a paradigm shift from disease‑centered care toward early prevention, integrated lifestyle interventions, and equitable health policies across the life course.

Keywords: Abdominal obesity, Cardiometabolic aging, Insulin resistance, Non communicable diseases

Full-Text [PDF 347 kb] (11 Downloads)

Type of Study: Editorial | Subject: Cardiology
Received: 2026/01/10 | Accepted: 2026/02/28 | ePublished ahead of print: 2026/03/11 | ePublished: 2026/03/6