Study of liver enzyme activity and oxidative stress biomarkers in individuals exposed to air pollutants in Tehran and Kohdasht

Azadbakht, Bahman; Dadfar, Fereshteh

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Research code: IR.PNU.REC.1404.065

Ethics code: IR.PNU.REC.1404.065

Study of liver enzyme activity and oxidative stress biomarkers in individuals exposed to air pollutants in Tehran and Kohdasht

Bahman Azadbakht¹

, Fereshteh Dadfar ^*²

1- Department of Biology, Payame Noor University, Tehran, Iran
2- Department of Biology, Payame Noor University, Tehran, Iran , fdadfar@pnu.ac.ir

Abstract: (24 Views)

Background and Aims: Given the importance and undeniable effects of air pollution on human health and the environment, especially in the last decade when its effects are clearly visible, the aim of the present study was to investigate and compare the activity of liver enzymes and oxidative stress factors in individuals exposed to air pollutants in Tehran and Kohdasht, Lorestan.
Materials and Methods: In this case-control study, 30 individuals living in Tehran as the group exposed to respiratory pollutants and 30 individuals living in Kohdasht, Lorestan as the non-exposed group (control) with aged 18-65 years were randomly selected. To investigate the activity of alanine transaminase, aspartate aminotransferase and alkaline phosphatase enzymes, enzymatic or colorimetric methods were used using a laboratory kit. To evaluate biomarkers of oxidative stress including malondialdehyde, total antioxidant capacity and glutathione, the Benzie and Strain, TBARS and Beutler methods were used. The data were analyzed using SPSS software and the t-test statistical method.
Results: The results of the study showed that there was no significant difference in liver enzyme activity between the group exposed to air pollutants (residents of Tehran) and the non-exposed group (residents of Kohdasht), (P>0.05). Evaluation of oxidative stress biomarkers also showed that the level of malondialdehyde in the two experimental groups did not differ significantly (P≤0.05). Total antioxidant capacity and glutathione in the group of Tehran residents exposed to air pollution showed a significant decrease compared to residents of Kohdasht (P≤0.05).
Conclusion: The results of the present study indicated the negative impact of air pollutants on the levels of liver enzymes and biomarkers of oxidative stress, which can lead to the development of chronic diseases and functional disorders in the liver.

Keywords: Kohdasht, Liver enzymes, Oxidative stress, Respiratory pollutants, Tehran

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Type of Study: Original Article | Subject: Physiology
Received: 2025/10/7 | Accepted: 2025/12/24 | ePublished ahead of print: 2026/01/28