Effects of Opium Uses on Hematological Parameters in COPD Patients

Nosrati, Fahime; Khazdair, Mohammad Reza; Mortazavi Moghaddam, Sayyed Gholamreza

doi:10.61186/JBUMS.32.1.17

Volume 32, Issue 1 (Spring 2025) J Birjand Univ Med Sci. 2025, 32(1): 17-26 | Back to browse issues page

‎ 10.61186/JBUMS.32.1.17

Ethics code: IR.BUMS.REC.1399.325

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Nosrati F, Khazdair M R, Mortazavi Moghaddam S G. Effects of Opium Uses on Hematological Parameters in COPD Patients. J Birjand Univ Med Sci. 2025; 32 (1) :17-26
URL: http://journal.bums.ac.ir/article-1-3512-en.html

Effects of Opium Uses on Hematological Parameters in COPD Patients

Fahime Nosrati¹

, Mohammad Reza Khazdair²

, Sayyed Gholamreza Mortazavi Moghaddam ^*³

1- Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
2- Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3- Department of Internal Medicine, School of Medicine, Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran , gmortazavi@yahoo.com

Abstract: (148 Views)

Background and Aims: Opium is a narcotic substance that has been used traditionally for several diseases, such as gastrointestinal, respiratory, and heart diseases in several areas. This study aimed to elucidate the correlations between opium usage and hematological parameters in patients diagnosed with chronic obstructive pulmonary disease (COPD).
Materials and Methods: The present case-control study included 100 COPD patients who were selected through a census method, regardless of disease severity. The participants provided informed consent and had no concurrent major organ diseases or advanced metabolic disorders. The diagnosis of COPD was based on medical history, clinical symptoms, and spirometry findings. Fasting blood samples were collected from the participants for hematological tests, and an additional blood sample was drawn into a separate syringe for venous blood gas analysis. The obtained data were analyzed using SPSS software (version 22). Descriptive data were reported using central tendency and dispersion indices (Mean±SD). A P-value of 0.05 was considered statistically significant.
Results: In total, 100 patients with COPD, including both opium users and non-users, were investigated in this study. The mean ages were 65.4±12.7 and 64.2±9.8 years for opium users and non-users, respectively. Moreover, the majority of the cases (n=61, 61%) were male, and 79 patients (79%) had a history of substance use. Among opium users, the level of cigarette consumption was lower; however, the use of hookah was significantly higher, compared to their non-user counterparts (P<0.01 for both parameters). Regarding the hematological parameters, the total white blood cell count and creatinine levels were significantly lower in the opium user group, compared to the non-user group (P<0.05). No significant differences were observed in the other parameters.

Conclusion: The findings of this study showed that opium addiction was common in COPD patients and changes in weight, height, and oxygen saturation were greater in opium users. Moreover, hypoventilation and increased CO² in the blood were reported in addicted patients. These results indicated the negative role of opium use in the clinical condition of COPD patients and the need for appropriate therapeutic interventions to manage addiction and improve the quality of life of these patients.

Keywords: Cholesterol, COPD, Hematological Parameters, Opium Addiction, White Blood Cell Count

Full-Text [PDF 481 kb] (40 Downloads)

Type of Study: Original Article | Subject: Respiratory Physiology
Received: 2025/04/8 | Accepted: 2025/06/2 | ePublished ahead of print: 2025/06/7 | ePublished: 2025/04/4

References

1. 1 Moezi SA, Azdaki N, Kazemi T, Partovi N, Hanafi Bojd N, Mashreghi Moghaddam HR, et al. The effects of opium uses on syntax score of angiography patients with coronary artery disease (CAD). Toxin Rev. 2022; 41(4): 1246-52. DOI: [DOI:10.1080/15569543.2021.2000434]

2. 2 Khatami S, Naseri M, Bahaeddin Z, Ghaffari F, Moosavizadeh A, Zahir NV. The perspective of traditional Persian medicine on botanicals effective in quitting opium addiction: a review. Trad Integr Med. 2021;6(4):444-54. URL: https://jtim.tums.ac.ir/index.php/jtim/article/view/373 [DOI:10.18502/tim.v6i4.8278]

3. 3 Quraishi R, Kathiresan P, Verma K, Rao R, Jain R. Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India. Indian J Psychiatry. 2022; 64(3): 252-6. URL: https://pubmed.ncbi.nlm.nih.gov/35859548/ [DOI:10.4103/indianjpsychiatry.indianjpsychiatry_751_21] [PMID] []

4. 4 Haghpanah T, Afarinesh M, Divsalar K. A review on hematological factors in opioid-dependent people (opium and heroin) after the withdrawal period Addict Health. 2010; 2(1-2): 9. URL: https://ahj.kmu.ac.ir/article_84527.html

5. 5 Bijani M, Dehghan A, Razavi S, Karimi S. Examining the association between opium use, cigarette smoking and alcohol consumption with the liver enzyme levels in a population-based study: Fasa Persian cohort data. BMC Res Notes. 2022; 15(1): 2. URL: https://pubmed.ncbi.nlm.nih.gov/34986881/ [DOI:10.1186/s13104-021-05891-3] [PMID] []

6. 6 Jamali Z, Noroozi Karimabad M, Khalili P, Sadeghi T, Sayadi A, Mohammadakbari Rostamabadi F, et al. Prevalence of dyslipidemia and its association with opium consumption in the Rafsanjan cohort study. Sci Rep. 2022; 12(1): 11504. URL: https://pubmed.ncbi.nlm.nih.gov/35798768/ [DOI:10.1038/s41598-022-13926-3] [PMID] []

7. 7 Mahmoodi M, Hosseini-Zijoud S-M, Hosseini J, Sayyadi A, Hajizadeh M, Hassanshahi G, et al. Opium withdrawal and some blood biochemical factors in addicts' individuals. Adv Biol Chem. 2012; 2(2): 167-70. URL: https://www.scirp.org/journal/paperinformation?paperid=18978 [DOI:10.4236/abc.2012.22020]

8. 8 Asadikaram G, Igder S, Jamali Z, Shahrokhi N, Najafipour H, Shokoohi M, et al. Effects of different concentrations of opium on the secretion of interleukin-6, interferon-γ and transforming growth factor beta cytokines from jurkat cells. Addict Health. 2015; 7(1-2): 47-53. https://ahj.kmu.ac.ir/article_84640.html

9. 9 Xuan L, Han F, Gong L, Lv Y, Wan Z, Liu H, et al. Association between chronic obstructive pulmonary disease and serum lipid levels: a meta-analysis. Lipids Health Dis. 2018; 17(1); 263. URL: https://pubmed.ncbi.nlm.nih.gov/30463568/ [DOI:10.1186/s12944-018-0904-4] [PMID] []

10. 10 Tariq S, Ismail D, Thapa M, Goriparthi L, Pradeep R, Khalid K, et al. Chronic obstructive pulmonary disease and its effect on red blood cell indices. Cureus. 2023; 15(3): e36100. URL: https://pubmed.ncbi.nlm.nih.gov/37065412/ [DOI:10.7759/cureus.36100]

11. 11 Burkhardt R, Pankow W. The diagnosis of chronic obstructive pulmonary disease. Dtsch Arztebl Int. 2014; 111(49): 834-45. URL: https://pubmed.ncbi.nlm.nih.gov/25556602/

12. 12 Raeisy L, Masoompour SM, Rezaianzadeh A. Evaluation of the prevalence of asthma and chronic obstructive pulmonary disease among opium users, and cigarette smokers and comparison with normal population in Kharameh: a cross-sectional study. BMC Pulm Med. 2023; 23(1): 419 URL: https://pubmed.ncbi.nlm.nih.gov/37914995/ [DOI:10.1186/s12890-023-02734-8] [PMID] []

13. 13 Lewer D, Cox S, Hurst JR, Padmanathan P, Petersen I, Quint JK. Burden and treatment of chronic obstructive pulmonary disease among people using illicit opioids: matched cohort study in England. BMJMED. 2022; 1(1): e000215 URL: https://pubmed.ncbi.nlm.nih.gov/36568709/ [DOI:10.1136/bmjmed-2022-000215] [PMID] []

14. 14 Walker PP, Thwaite E, Amin S, Curtis JM, Calverley PM. The association between heroin inhalation and early onset emphysema. Chest. 2015; 148(5): 1156-63. URL: https://pubmed.ncbi.nlm.nih.gov/26020453/ [DOI:10.1378/chest.15-0236] [PMID]

15. 15 Beuther DA. Hypoventilation in asthma and chronic obstructive pulmonary disease.Semin Respir Crit Care Med. 2009; 30(3): 321-9. URL: https://pubmed.ncbi.nlm.nih.gov/19452392/ [DOI:10.1055/s-0029-1222446] [PMID]

16. 16 Hassan A, Jabbar N. C-reactive protein as a predictor of severity in chronic obstructive pulmonary disease: an experience from a tertiary care hospital. Cureus. 2022; 14 (8): e28229. URL: https://pubmed.ncbi.nlm.nih.gov/36017482/ [DOI:10.7759/cureus.28229]

17. 17 Reece AS. High-sensitivity CRP in opiate addiction: relative and age-dependent elevations. Cardiovasc Toxicol. 2012; 12(2): 149-57. URL: https://pubmed.ncbi.nlm.nih.gov/22297435/ [DOI:10.1007/s12012-012-9154-2] [PMID]

18. 18 Onikzeh P, Kazemi A, Rahmani F, Masoomi M, Moridi M. The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography. J Kerman Univ Med Sci. 2022; 29(4): 348- 57. URL: https://jkmu.kmu.ac.ir/article_92010.html

19. 19 Hoseini SS, Saadatjoo SA, Nakhaee S, Amirabadizadeh A, Rezaie M, Mehrpour O. Potential effect of opium addiction on lipid profile and blood glucose concentration in type 2 diabetic patients in Iran. J Subst Use. 2019; 24(4): 420-5. DOI: [DOI:10.1080/14659891.2019.1588404]

20. 20 Mohammadi A, Darabi M, Nasry M, Saabet-Jahromi M-J, Malek-Pour-Afshar R, Sheibani H. Effect of opium addiction on lipid profile and atherosclerosis formation in hypercholesterolemic rabbits. Exp Toxicol Pathol. 2009; 61(2): 145-9. URL: https://pubmed.ncbi.nlm.nih.gov/18838257/ [DOI:10.1016/j.etp.2008.08.001] [PMID]

21. 21 Yousefzadeh G, Shokoohi M, Najafipour H, Eslami M, Salehi F. Association between opium use and metabolic syndrome among an urban population in Southern Iran: Results of the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS). ARYA Atheroscler. 2015; 11(1): 14-20. URL: https://arya.mui.ac.ir/article_10450.html

22. 22 Najafipour H, Beik A. The impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms. Front Physiol. 2016; 7: 436. DOI: doi: 10.3389/fphys.2016.00436 PMCID: PMC:5061814 PMID: 27790151 [DOI:10.3389/fphys.2016.00436] [PMID] []

23. 23 Du W, Guan H, Wan X, Zhu Z, Yu H, Luo P, et al. Circulating liver function markers and the risk of COPD in the UK Biobank. Front Endocrinol (Lausanne). 2023; 14: 1121900. PMCID: PMC10073719 DOI: 10.3389/fendo.2023.1121900 [DOI:10.3389/fendo.2023.1121900] [PMID] []

24. 24 Asadikaram G, Vakili S, Akbari H, Kheirmand-Parizi M, Sadeghi E, Asiabanha M, et al. Effects of opium addiction on some biochemical factors in diabetic rats.Addict Health. 2018; 10(2): 123. DOI: 10.22122/ahj.v10i2.531 PMID: 31069036

25. 25 Askari M, Askari Z, Zarei Z, Farjam M, Homayounfar R, Mahmoudi Kohani HA. Prevalence of general and abdominal obesity and its relationship with opium, total opiate drugs, and chronic smoking: Fasa cohort study. Diabetes Metab Syndr. 2022; 16(1): 102357. URL: https://pubmed.ncbi.nlm.nih.gov/34920194/ PMID: 34920194 [DOI:10.1016/j.dsx.2021.102357] [PMID]

26. 26 Baldo BA. Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity. Arch Toxicol. 2021; 95(8): 2627-42. URL: https://pubmed.ncbi.nlm.nih.gov/33974096/ PMID: 33974096 [DOI:10.1007/s00204-021-03068-2] [PMID]