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1- Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran
2- Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Yasouj, Yasouj, Iran ,Omidzafarmand2202@gmail.com
2- Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Yasouj, Yasouj, Iran ,
Abstract: (123 Views)
Background and Aims: Exercise, as a practical strategy, plays a crucial role in increasing sirtuin 1 protein levels, improving lipid profiles, and preventing complications of overweight and obesity. Therefore, the present study aimed to investigate the effects of exercise training on sirtuin 1 protein levels and lipid profiles in adults with and without chronic diseases.
Materials and Methods: In the present meta-analysis research, a systematic search of English and Persian studies published in PubMed, Web of Science, Scopus, SID, and Magiran databases was conducted until September 2024. Weighted mean difference and 95% confidence interval (CI) were calculated using random effect model. Heterogeneity was evaluated using the (I2) test, and publication bias was evaluated by visual analysis of the funnel plot and Egger's test.
Results: A total of 13 studies (with 15 interventions) and 398 adults with and without chronic diseases were meta-analyzed. The results showed that exercise training significantly increased sirtuin 1 [WMD=1.479 (1.103 to 1.856) P=0.001] and high density lipoprotein [WMD=-9.884 (5.166 to 14.603) P=0.001], compared to the control group. However, exercise training significantly decreased total Cholesterol [WMD=-14.071 (-20.057 to -8.085), P=0.001], triglyceride [WMD=-19.616 (-24.058 to -15.175), P=0.001], and low density lipoprotein [WMD=-15.636 (-21.911 to -9.361), P=0.001], compared to the control group in adults with and without chronic diseases.
Conclusion: The results of the present meta-analysis showed that exercise has a positive effect on sirtuin 1 levels and lipid profile indices in adults with and without chronic diseases.
Materials and Methods: In the present meta-analysis research, a systematic search of English and Persian studies published in PubMed, Web of Science, Scopus, SID, and Magiran databases was conducted until September 2024. Weighted mean difference and 95% confidence interval (CI) were calculated using random effect model. Heterogeneity was evaluated using the (I2) test, and publication bias was evaluated by visual analysis of the funnel plot and Egger's test.
Results: A total of 13 studies (with 15 interventions) and 398 adults with and without chronic diseases were meta-analyzed. The results showed that exercise training significantly increased sirtuin 1 [WMD=1.479 (1.103 to 1.856) P=0.001] and high density lipoprotein [WMD=-9.884 (5.166 to 14.603) P=0.001], compared to the control group. However, exercise training significantly decreased total Cholesterol [WMD=-14.071 (-20.057 to -8.085), P=0.001], triglyceride [WMD=-19.616 (-24.058 to -15.175), P=0.001], and low density lipoprotein [WMD=-15.636 (-21.911 to -9.361), P=0.001], compared to the control group in adults with and without chronic diseases.
Conclusion: The results of the present meta-analysis showed that exercise has a positive effect on sirtuin 1 levels and lipid profile indices in adults with and without chronic diseases.
Type of Study: Meta-analysis |
Subject:
Exercise Physiology
Received: 2024/12/3 | Accepted: 2025/02/3 | ePublished ahead of print: 2025/03/5
Received: 2024/12/3 | Accepted: 2025/02/3 | ePublished ahead of print: 2025/03/5
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