A rare presentation of Sjogren's syndrome with ascites and liver fibrosis in a young woman: a Case report

Farzaneh Far, Mohammad Reza; Miri, Maryam; Naghibian, Farimah; Amerizadeh, Forouzan; Salari, Masoumeh

doi:10.61186/JBUMS.31.2.182

Volume 31, Issue 2 (July 2024) J Birjand Univ Med Sci. 2024, 31(2): 182-189 | Back to browse issues page

‎ 10.61186/JBUMS.31.2.182

Research code: کیس ریپورت طرح پژوهشی ندارد

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Farzaneh Far M R, Miri M, Naghibian F, Amerizadeh F, Salari M. A rare presentation of Sjogren's syndrome with ascites and liver fibrosis in a young woman: a Case report. J Birjand Univ Med Sci. 2024; 31 (2) :182-189
URL: http://journal.bums.ac.ir/article-1-3432-en.html

A rare presentation of Sjogren's syndrome with ascites and liver fibrosis in a young woman: a Case report

Mohammad Reza Farzaneh Far¹

, Maryam Miri²

, Farimah Naghibian³

, Forouzan Amerizadeh³

, Masoumeh Salari ^*

⁴

1- Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Kidney transplantation complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Research Center for Rheumatic Diseases, Mashhad University of Medical Sciences, Mashhad, Iran , salarim@mums.ac.ir

Abstract: (294 Views)

Primary Sjogren's syndrome is a systemic autoimmune disease that encompasses a wide range of manifestations, including exocrine gland involvement and extra-glandular symptoms. This case report deals with the history of a 26-year-old woman presented with ascites and peripheral edema and without any medical history or recent drug use. Initial tests demonstrated leukopenia, anemia, and thrombocytopenia, as well as normal liver and kidney function. Ascitic fluid analysis A indicated liver involvement, and imaging displayed significant fibrosis in the liver. Additional laboratory tests showed positive antinuclear antibodies (ANA), anti-Sjögren's syndrome-related antigen A (SS-A), and anti-Sjögren's syndrome-related antigen B (SS-B) antibodies. Moreover, a minor salivary gland biopsy confirmed the diagnosis of Sjogren's syndrome. The patient was treated with prednisolone, hydroxychloroquine, and mycophenolate mofetil, which led to the reduction of ascites and edema and the improvement of cytopenia. This report highlighted the importance of considering Sjogren's syndrome in patients with liver fibrosis and unexplained ascites.

Keywords: Ascites, Autoimmune disease, Liver fibrosis, Sjogren's syndrome

Full-Text [PDF 353 kb] (92 Downloads)

Type of Study: Case Report | Subject: Rheumatology
Received: 2024/06/12 | Accepted: 2024/08/11 | ePublished ahead of print: 2024/09/15 | ePublished: 2024/08/5

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