Volume 31, Issue 2 (July 2024)
JBUMS 2024, 31(2): 150-160 |
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Research code: 1400.12
Ethics code: LU.ECRA.2023.52
Clinical trials code: testnew for site
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Mohammadzadeh S, Amiri M. The effects of liraglutide on the characteristics of blood parameters and testicular tissue induced diabetes and obesity in mice. JBUMS 2024; 31 (2) :150-160
URL: http://journal.bums.ac.ir/article-1-3400-en.html
URL: http://journal.bums.ac.ir/article-1-3400-en.html
1- Department of Animal Science, Faculty of Agriculture, Lorestan University, Khoramabad, Iran , Mohammadzadeh.s@lu.ac.ir
2- Department of Animal Science, Faculty of Agriculture, Lorestan University, Khoramabad, Iran
2- Department of Animal Science, Faculty of Agriculture, Lorestan University, Khoramabad, Iran
Abstract: (145 Views)
Background and Aims: Obesity and diabetes are the most common metabolic disorders that have negative effects on organisms, including the reproductive system. The drug treatments cause fertility disorders. One of the candidate drugs is liraglutide. The present study sought to assess the effect of liraglutide on testicular tissue and blood parameters, especially C-reactive protein (inflammation index).
Materials and Methods: A total of 40 adult male mice were assigned to five groups with eight replications. These groups included control, obese, obese+liraglutide injected 1.2 mg/kg of body weight, diabetes, and the last group, diabetes+liraglutide injected 1.2 mg/kg of body weight. Liraglutide was injected subcutaneously daily. The duration of the experiment was six weeks. After the end of the experiment, the animals were anesthetized, and blood samples and testicular sections were taken. Animals were euthanized (cervical dislocation). The testicles were removed and fixed. The tissue sections were prepared according to the usual protocol.
Results: The results demonstrated that the diameter of seminiferous tubules in obese and diabetic groups was increased by liraglutide injection (P<0.01). Diabetes and obesity decreased the thickness of the germ cell epithelium of seminiferous tubules (P<0.01). The C-reactive protein decreased in diabetic and obese groups when injected with liraglutide (P<0.01).
Conclusion: As evidenced by the results obtained, liraglutide can improve the male reproductive system and reduce chronic inflammation caused by obesity and diabetes.
Materials and Methods: A total of 40 adult male mice were assigned to five groups with eight replications. These groups included control, obese, obese+liraglutide injected 1.2 mg/kg of body weight, diabetes, and the last group, diabetes+liraglutide injected 1.2 mg/kg of body weight. Liraglutide was injected subcutaneously daily. The duration of the experiment was six weeks. After the end of the experiment, the animals were anesthetized, and blood samples and testicular sections were taken. Animals were euthanized (cervical dislocation). The testicles were removed and fixed. The tissue sections were prepared according to the usual protocol.
Results: The results demonstrated that the diameter of seminiferous tubules in obese and diabetic groups was increased by liraglutide injection (P<0.01). Diabetes and obesity decreased the thickness of the germ cell epithelium of seminiferous tubules (P<0.01). The C-reactive protein decreased in diabetic and obese groups when injected with liraglutide (P<0.01).
Conclusion: As evidenced by the results obtained, liraglutide can improve the male reproductive system and reduce chronic inflammation caused by obesity and diabetes.
Type of Study: Original Article |
Subject:
Physiology
Received: 2024/03/17 | Accepted: 2024/06/29 | ePublished ahead of print: 2024/06/30 | ePublished: 2024/08/5
Received: 2024/03/17 | Accepted: 2024/06/29 | ePublished ahead of print: 2024/06/30 | ePublished: 2024/08/5
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