Volume 27, Issue 1 (April 2020)
J Birjand Univ Med Sci. 2020, 27(1): 90-99 |
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Mansouri B, Rezaei M, Javadmoosavi S Y, Amirabadi A. Evaluate the serum level of magnesium, manganese, and selenium in patients with hypothyroidism, hyperthyroidism and thyroid cancer in South Khorasan in 2018. Journals of Birjand University of Medical Sciences 2020; 27 (1) :90-99
URL: http://journal.bums.ac.ir/article-1-2696-en.html
URL: http://journal.bums.ac.ir/article-1-2696-en.html
1- Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran; ,dr.rezaei.maryam@gmail.com
3- Student Research committee, Birjand University of Medical Sciences, Birjand, Iran
4- Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran
2- Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran; ,
3- Student Research committee, Birjand University of Medical Sciences, Birjand, Iran
4- Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran
Abstract: (5010 Views)
Background and Aim: Metabolic thyroid disease is one of the most common diseases in adults. On the other hand, environmental pollutants, including heavy metals, can interfere with hormonal function. So, the aim of this study was to evaluate the serum level of magnesium, manganese, and selenium in patients with hypothyroidism, hyperthyroidism and thyroid cancer in South Khorasan in 2018.
Materials and Methods: In this study, 77 patients were evaluated in three groups: hypothyroidism (n=33), hyperthyroidism (n=33) and cancer (n=11). After receiving the consent of the patients, their demographic information were collected. Sampling was convenient sampling method. Then, 10 ml of venous blood after 12 hours of fasting were taken. After the serum preparation, the levels of trace elements were assayed by ICP-MS.
Results: The mean level of the studied metals (except for manganese) were not significantly different in the three groups (p> 0.05). The level of magnesium, manganese, and selenium in the hypothyroidismwere 1.74±0.55, 6.30±4.88, and 1.38±0.80; in the hyperthyroidism were 1.77±0.41, 5.55±4.55, and 1.47±0.70; and in the thyroid cancer group were 2.07±0.81, 6.02±2.22 and 1.84±1.03 respectively (p<0.05).
Conclusion: According to the findings of this study, the changes in the trace element status can lead to a type of thyroid disorder, or even these disorders may alter the serum levels of these metals. But this difference, except for manganese metal, was not significant in other cases, however, further studies with other metals and elsewhere are recommended.
Materials and Methods: In this study, 77 patients were evaluated in three groups: hypothyroidism (n=33), hyperthyroidism (n=33) and cancer (n=11). After receiving the consent of the patients, their demographic information were collected. Sampling was convenient sampling method. Then, 10 ml of venous blood after 12 hours of fasting were taken. After the serum preparation, the levels of trace elements were assayed by ICP-MS.
Results: The mean level of the studied metals (except for manganese) were not significantly different in the three groups (p> 0.05). The level of magnesium, manganese, and selenium in the hypothyroidismwere 1.74±0.55, 6.30±4.88, and 1.38±0.80; in the hyperthyroidism were 1.77±0.41, 5.55±4.55, and 1.47±0.70; and in the thyroid cancer group were 2.07±0.81, 6.02±2.22 and 1.84±1.03 respectively (p<0.05).
Conclusion: According to the findings of this study, the changes in the trace element status can lead to a type of thyroid disorder, or even these disorders may alter the serum levels of these metals. But this difference, except for manganese metal, was not significant in other cases, however, further studies with other metals and elsewhere are recommended.
Type of Study: Original Article |
Subject:
Endocrinology
Received: 2019/07/2 | Accepted: 2019/11/6 | ePublished: 2020/03/2
Received: 2019/07/2 | Accepted: 2019/11/6 | ePublished: 2020/03/2
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