Volume 24, Issue 4 (January 2017)
J Birjand Univ Med Sci. 2017, 24(4): 243-253 |
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Danesh N M, Yousefi F, Nameghi M A, Abnous K, Taghdisi S M. Aptamers: Isolation, modification, characteristics, and applications
. J Birjand Univ Med Sci. 2017; 24 (4) :243-253
URL: http://journal.bums.ac.ir/article-1-2382-en.html
URL: http://journal.bums.ac.ir/article-1-2382-en.html
Noor Mohammad Danesh1, Farzaneh Yousefi2, Morteza Alinezhad Nameghi3, Khalil Abnous4, Seyed Mohammad Taghdisi *5
1- Research Institute of Sciences and New Technology, Mashhad, Iran
2- MSc of Nursing, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
3- MSc, School of Pharmacy, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad, Iran
4- Professor, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Assistant Professor, School of Pharmacy, Department of Pharmaceutical Biotechnology , Mashhad University of Medical Sciences, Mashhad, Iran , taghdisihm@mums.ac.ir
2- MSc of Nursing, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
3- MSc, School of Pharmacy, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad, Iran
4- Professor, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Assistant Professor, School of Pharmacy, Department of Pharmaceutical Biotechnology , Mashhad University of Medical Sciences, Mashhad, Iran , taghdisihm@mums.ac.ir
Abstract: (7815 Views)
As synthetic oligonucleotides with high affinity and selectivity, aptamers have an outstanding potential for medical diagnosis and treatment. This manuscript enquires into the generation, characteristics and applications of aptamers. The role of aptamers in medicine is also discussed. The study shows that aptamers stand as great candidates in medical sciences for development of biosensors and targeted drug delivery systems because of their unique properties such as high affinity and selectivity towards their targets, inexpensiveness and in vitro synthesis, high stability, and small size.
Type of Study: Review |
Subject:
Biotechnology
Received: 2017/12/9 | Accepted: 2018/01/21 | ePublished ahead of print: 2018/01/21 | ePublished: 2018/02/8
Received: 2017/12/9 | Accepted: 2018/01/21 | ePublished ahead of print: 2018/01/21 | ePublished: 2018/02/8
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