Determination of serum adiponectin relationship with insulin resistance in type 2 diabetics

Eizadi, Mojtaba; Kazemzade, Yaser; Behbudi, Laleh; Banaeifar, Abdolali

Volume 20, Issue 4 (Winter 2013) J Birjand Univ Med Sci. 2013, 20(4): 393-400 | Back to browse issues page

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Eizadi M, Kazemzade Y, Behbudi L, Banaeifar A. Determination of serum adiponectin relationship with insulin resistance in type 2 diabetics. Journals of Birjand University of Medical Sciences 2013; 20 (4) :393-400
URL: http://journal.bums.ac.ir/article-1-1249-en.html

Determination of serum adiponectin relationship with insulin resistance in type 2 diabetics

Mojtaba Eizadi ^*¹

, Yaser Kazemzade²

, Laleh Behbudi²

, Abdolali Banaeifar³

1- in Physical Education and Sport Science, Saveh Branch, Islamic Azad University Saveh, Iran , izadimojtaba2006@yahoo.com
2- in Physical Education and Sport Science, Islamshahr Branch, Islamic Azad University Islamshahr, Iran.
3- in Physical Education and Sport Science, South Tehran Branch, Islamic Azad University Tehran, Iran.

Abstract: (13597 Views)

Background and Aim: Obesity is associated with some chronic morbidity including atherosclerosis, hypertension, and type 2 diabetes which are major components of metabolic syndrome. In the present study, association between insulin resistance and adiponectin, as an anti-inflammatory cytokine, in type 2 obese male diabetics was assessed. Materials and Methods: In this descriptive study, fasting serum adiponectin, insulin, glucose and insulin resistance were measured in 42 obese male type 2 diabetics (aged 37 - 53 years, weight 80-100kg, 30≤BMI≤36). Pearson’s correlation method was used to determine the association between adiponectin levels with insulin resistance, glucose, and insulin in the cases (P≤0.05). Results: Pearson’s correlation method showed a significant negative association between serum adiponectin andinsulin resistance (P=0.000(. Besides, a significant correlation was observed between adiponectin level and fasting glucose (P=0.005). But, no correlation was found between serum adiponectin and insulin (P=0.196). Conclusion: The current study demonstrated that serum adiponectin level, as an anti-inflammation and anti-diabetic cytokine, is a predictive factor of insulin resistance in type 2 diabetics.

Keywords: Obesity, Diabetic, Insulin resistance, Adiponectin

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Type of Study: Original Article | Subject: Physiology
Received: 2012/09/20 | Accepted: 2013/10/30 | ePublished: 2014/03/9