Volume 20, Issue 3 (October 2013)                   J Birjand Univ Med Sci. 2013, 20(3): 288-294 | Back to browse issues page

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Vakili T, Eftekhar E, Nourooz Zadeh J, Khademvatan K, Salary Lak S. Inter-relationships between inflammatory biomarkers and severity of angiographically verified coronary artery occlusion. J Birjand Univ Med Sci. 2013; 20 (3) :288-294
URL: http://journal.bums.ac.ir/article-1-1234-en.html
Inter-relationships between inflammatory biomarkers and severity of angiographically verified coronary artery occlusion
Tahereh Vakili1, Ebrahim Eftekhar2, Jaffar Nourooz Zadeh *3, Kamal Khademvatan4, Shaker Salary Lak5
1- Department of Biochemistry and nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
2- Molecular Medicine Research Center and Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3- Department of Biochemistry and nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , jnouroozzadeh@yahoo.co.uk
4- Department of Cardiovascular disease, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
5- Department of Epidemiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Abstract:   (14207 Views)
Background and Aim: Growing clinical evidence suggests that inflammation is the hallmark of the initiation, progression and extent of occlusion by atherosclerosis plaques, but biochemical data are still controversial. The aim of the present cross-sectional investigation was to evaluate the relationship between the severity of coronary artery occlusion (CAO), serum amyloid A (SAA), and interleukin -6 (IL-6) Materials and Methods: The subjects assessed were165 having stable coronary artery disease, but without left main artery lesion. Angiographic examination revealed that 37 subjects had minimal CAO (control group), 41 one CAO, 41 two CAO , and 47 three CAO. The Subjects’ SAA and IL-6 were assessed by means of ELISA.The level of fibrinogen was estimated using coaglumetry. The obtained data was analysed by means of SPSS (v: 13). Results: Fibrinogen concentrations were significantly higher in subjects with 1, 2 or 3 CAO compared to the controls. SAA levels in the subjects were higher than those in the controls, but the differences were not statistically significant. On the other hand, IL6- concentrations in patients with a varying degree of CAO were similar but slightly lower than those in the controls. Significant correlations were distinguished between SAA, IL-6, and fibrinogen in the patients as a whole (p=0.05). Fibrinogen levels in the patients were significantly correlated with HDL and LDL. Conclusion: It was found that fibrinogen estimation is .superior to IL-6 and SAA in examining the interrelationship between inflammation and progression of CAO.
Keywords: Inflammation, Coronary artery occlusion, Fibrinogin, Interleukin-6, Serum amyloid A
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Type of Study: Original Article | Subject: Cardiology
Received: 2012/09/17 | Accepted: 2013/04/29 | ePublished: 2013/12/11
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