Volume 31, Issue 2 (July 2024)
Journal of Scientific Research in Medical Sciences. 2024, 31(2): 182-189 |
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Research code: کیس ریپورت طرح پژوهشی ندارد
Ethics code: کیس ریپورت طرح پژوهشی ندارد
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Farzaneh Far M R, Miri M, Naghibian F, Amerizadeh F, Salari M. A rare presentation of Sjogren's syndrome with ascites and liver fibrosis in a young woman: a Case report. Journal of Scientific Research in Medical Sciences. 2024; 31 (2) :182-189
URL: http://journal.bums.ac.ir/article-1-3432-en.html
URL: http://journal.bums.ac.ir/article-1-3432-en.html
Mohammad Reza Farzaneh Far1 
, Maryam Miri2 , Farimah Naghibian3 , Forouzan Amerizadeh3 , Masoumeh Salari * 4
, Maryam Miri2 , Farimah Naghibian3 , Forouzan Amerizadeh3 , Masoumeh Salari * 4
1- Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Kidney transplantation complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Research Center for Rheumatic Diseases, Mashhad University of Medical Sciences, Mashhad, Iran ,salarim@mums.ac.ir
2- Kidney transplantation complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Research Center for Rheumatic Diseases, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (77 Views)
Primary Sjogren's syndrome is a systemic autoimmune disease that encompasses a wide range of manifestations, including exocrine gland involvement and extra-glandular symptoms. This case report deals with the history of a 26-year-old woman presented with ascites and peripheral edema and without any medical history or recent drug use. Initial tests demonstrated leukopenia, anemia, and thrombocytopenia, as well as normal liver and kidney function. Ascitic fluid analysis A indicated liver involvement, and imaging displayed significant fibrosis in the liver. Additional laboratory tests showed positive antinuclear antibodies (ANA), anti-Sjögren's syndrome-related antigen A (SS-A), and anti-Sjögren's syndrome-related antigen B (SS-B) antibodies. Moreover, a minor salivary gland biopsy confirmed the diagnosis of Sjogren's syndrome. The patient was treated with prednisolone, hydroxychloroquine, and mycophenolate mofetil, which led to the reduction of ascites and edema and the improvement of cytopenia. This report highlighted the importance of considering Sjogren's syndrome in patients with liver fibrosis and unexplained ascites.
Type of Study: Case Report |
Subject:
Rheumatology
Received: 2024/06/12 | Accepted: 2024/08/11 | ePublished ahead of print: 2024/09/15 | ePublished: 2024/08/5
Received: 2024/06/12 | Accepted: 2024/08/11 | ePublished ahead of print: 2024/09/15 | ePublished: 2024/08/5
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