Journal of Translational Medical Research

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Background and Aim: In present more than one million people in world doing hemodialysis, This study do to determine adequacy of dialysis in hemodialysis patients Vali-Asr Hospital in Birjand.
Materials and Methods: Descriptive cross- sectional and 50 dialysis patients six months after they started dialysis were selected. The questionnaire measured individual data and recorded the weight before and after dialysis and blood urea before and after dialysis within a minute of slow blood to 50 ml of blood from the patient's body and back venus. Then, measured URR and Kt/V, the distribution of patients in three part low, moderate and high adequacy of dialysis. Statistical analysis were used by descriptive statistics and SPSS software.
Results: The mean age were 47.70 ± 16.72 years, weight before dialysis 58.2 ± 12.36 and after hemodialysis 56.2 ± 12.22 kg, mean BMI 21.40, urea before dialysis was 140.42 ± 37.92, urea after dialysis was 52.32 ± 16.75 mg dl. 70 percent of patients was Kt/V 0.9-1.2 and 66 percent URR between 61 and 70 percent that had a relatively good level of adequacy of dialysis. mean total Kt/V of patients were 1.17 and URR 62.8 percent. Between BMI, the average pump blood, sex patients and the number of time of dialysis at week with dialysis adequacy were significant relationship (P < 0.05).
Conclusion: Prevention of ESRD at the community level and attention to details such as the choise strategy to increase hours of dialysis, filter type and time of dialysis at week is important in dialysis wards.

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Background and Aim: Aloe Vera gel, with strong antioxidant properties, is used in the treatment of many renal disorders. This study aimed to evaluate the effect of Aloe Vera gel (JA) on urea, uric acid and creatinine levels of serum, and tissue structure of kidneys of rats diagnosed with MS through Ethidium Bromide (EB).
Materials and Methods: This experimental study was performed on 48 female rats, which were divided into 6 groups of 8 samples, including control, sham (intraventricular treatment with saline), experimental treated with 14 μl of EB solution to the lateral ventricles with normal saline as a Gavage and receivers of 300, 600 and 1200 mg/ kg alcoholic extracts )JA(, as gavage with EB intraventricular  meditation. In this study, prescriptions were taken for 35 days. In the end, after blood sampling from animal’s heart, some amount of urea, uric acid, and creatinine are extracted, and with providing different cross- sections, the tissue structure of their kidneys was studied based on histologic measurements. Finally, the data were analyzed using SPSS software (Version 20) using ANOVA and Duncan tests at the level of P <0.05.
Results: The results showed that EB increased serum urea, uric acid, and creatinine levels, decreased the diameter of the medulla, glomerulus, renal corpuscle sections, and increased the diameter of the near and further curved tubes at the level of P≤0.05. Furthermore, the treatment with high-dose JA significantly reduced the serum urea, uric acid and creatinine levels, increased the diameter of medulla sections, glomerulus, renal corpuscle, and reduced the near and further curved tubes alone in comparison with the EB group at P≤0.05.
Conclusion: Aloe Vera gel, in dose-dependent forms, can reduce urea, uric acid, creatinine, and tissue modification of kidneys in animals with MS.

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Background and Aim: Helicobacter Pylori is one of the human gastrointestinal tract bacteria that affects more than 50% of the world's population. Eradication of Helicobacter with an effective regimen with low cost and minor side effects is very worthwhile. The aim of this study is to evaluate the rate of Helicobacter Pylori eradication by adding green tea extract to the common 3 drugs regimen consist of amoxicillin, clarithromycin, and pantoprazole in Birjand.
Materials and Methods: In this randomized controlled clinical trial study, 30 patients in the case group and 30 Persons in the control group were enrolled. Diagnosis in patients with dyspepsia was performed based on endoscopy or urea breath test according to the clinical setting. The case group was treated with the common 3-drug regimen and green tea extract, and the control group was treated with common 3-drug regimen alone for 14 days. Eight weeks after treatment for Helicobacter Pylori eradication, urea breath test results were compared in two groups.
Results: The rate of eradication of Helicobacter pylori infection in the addition of green tea to 3 drug regimen based on clarithromycin (experimental group) was 90%, which was 13.7% more than the control group. The rate of eradication in the control group was 76.7%. There was no significant difference between the two groups in terms of side effects in both experimental and control groups.
Conclusion: Although the difference in the degree of eradication in the two groups was not statistically significant, But given the importance of increasing eradication at the limit Add side effects such as bismuth with metronidazole without adding complications And having other beneficial effects of green tea, These results are clinically valuable. According to the results of this study, green tea can be added as a useful supplement in the treatment of Helicobacter Pylori infection along with the common 3 drug regimen.