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Effect of Valsartan on the hormones of Pituitary-gonadal axis Performance in mature female Wistar Rats
Seyyed Ebrahim Hosseini, Mozhde Hjeidari,
Volume 19, Issue 4 (12-2012)
Abstract
Background and Aim: Valsartan as a receptor antagonist angiotensin-II (AngII) is used to treat blood pressure disorders and affects various tissues of the body. Thus,the present study was performed to investigate the effect of Valsartan on the axis of the pituitary-gonadal axis in mature female rats. Materials and Methods: In this research, 40 mature female Wistar rats were randomly divided into 8 member groups including control, sham and experimental groups. Initially, all the animals were homogenized through intramuscular injection of estradiol valerate and progesterone. Then the animals of sham group daily received 1 ml of olive oil (solvent) and the experimental groups were gavaged daily doses of 100, 200 and 400 mg/ Kg Wt , of Valsartan The control group members were not Administered anything. All drugs were administered for 21 days and at the end of the period, through deriving blood from the heart of animals the required serum was prepared by means of relevant hormonal kits to measure the levels of FSH, LH, estrogen and progesterone. The obtained data was evaluated using ANOVA and Tukey tests ,and P< 0/05 was taken as the significant level. Results: Statistical results analysis showed that Valsartan caused a significant reduction in hormones of FSH, LH, estrogen and progesterone. Conclusion: Valsartan , as a receptor antagonist of Ang II inhibits the secretion of gonadotropin hormones and accelerates their effect on blocking the follicular cells of the female sex ,causing the reduction of female hormones.
Protective effect of vitamin D on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), testosterone hormones and testicular tissue changes induced by methotrexate in adult male rats
Mahnaz Dehghani, Mehrdad Shariati, Davood Moghadamnia,
Volume 29, Issue 3 (12-2022)
Abstract
Background and Aims: Vitamin D has antioxidant and anti-inflammatory activities. The present study aimed to investigate the protective effect of vitamin D on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), testosterone hormones and testicular tissue changes induced by methotrexate in adult male rats.
Materials and Methods: In this experimental study, 30 adult male Wistar rats weighing 230-260 g were divided into six groups (n=5). Control group: They received no extract or solvent, sham group: 1 ml of distilled water as a solvent, treatment group 1: methotrexate (5 mg/kg) (gavage), treatment group 2: vitamin D (1000 IU/kg), treatment group 3: methotrexate (5 mg/kg) + vitamin D (500 IU/kg), and treatment group 4: methotrexate (5 mg/kg) + vitamin D (1000 IU/kg). After 28 days of treatment in the form of gavage, blood was taken directly from the heart to measure the serum concentration of LH, FSH, and testosterone hormones. The testes were removed and tissue changes were examined with hematoxylin-eosin staining. The collected data were analyzed using SPSS (version 18), one-way analysis of variance, and post hoc Tukey's test.
Results: In the group receiving methotrexate, the level of testosterone hormone, the number of spermatogonia (P>0.001), spermatocytes (P>0.001), sperm (P>0.001) and Leydig cells (P>0.001) decreased and the serum level of LH (P>0.001) and FSH (P>0.001) increased significantly compared to the control and sham groups. In groups receiving methotrexate + vitamin D, vitamin D was able to compensate for the adverse effects caused by methotrexate.
Conclusion: Our results showed that vitamin D could improve LH, FSH, testosterone hormones, and testicular tissue changes induced by methotrexate in adult male rats.

Effect of the hydroalcoholic extract of melon seeds (Cucumis melo L.) on the pituitary-gonadal axis and testicular tissue changes in adult male rats
Mandana Arabi, Mokhtar Mokhtari, Mehrdad Shariati, Davood Moghadamnia,
Volume 30, Issue 2 (10-2023)
Abstract
Background and Aims: Melon seeds have estrogenic, anti-cancer, anti-diabetic, anti-obesity, and antioxidant effects. The present study aimed to investigate the effect of the hydroalcoholic extract of melon seeds on the pituitary-gonadal axis and the tissue changes of the testis in adult male rats.
Materials and Methods: In this experimental study, 50 adult male Wistar rats weighing 210-230 g were assigned to five groups (n=10). The Control group received no extract or solvent; Sham group: 1 ml of distilled water as a solvent; experimental group 1: Melon seed extract (50 mg/kg), experimental group 2: Melon seed extract (100 mg/kg), Experimental group 3: Melon seed extract (150 mg/kg). After 21 days of treatment by the intraperitoneal method, blood was taken from the animals. The serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured by radioimmunoassay (RIA). Thereafter, the testicles were removed, and tissue changes were examined by hematoxylin-eosin staining. The collected data were analyzed in SPSS software (version 18) using a one-way analysis of variance and post hoc Tukey's test.
Results: The mean body weight in experimental groups 2 and 3 demonstrated a significant decrease compared to the control and sham groups (P<0.001). The mean weight of the testes in experimental groups 2 and 3 displayed a significant increase compared to the control and sham groups. The mean concentration of testosterone hormones, FSH, LH, the number of spermatogonial cells, primary spermatocytes, spermatids, Sertoli, and Leydig cells, as well as the number of sperm cells in experimental group 3,  had a significant increase compared to the control and sham groups (P<0.001).
Conclusion: As evidenced by the results of this study, the hydroalcoholic extract of melon seeds had stimulating effects on the pituitary-gonadal axis and testicular tissue in adult male rats.
 

*Corresponding Author: Davood Moghadamnia; Emails: davood.moghadamnia@gmail.com

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