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Comparison of Brucellosis anti-antibody levels following treatment with Streptomycin + Doxycycline and Rifampin + Doxycycline
A. Ebrahimzadeh, F. Madarshahian,
Volume 15, Issue 4 (12-2008)
Abstract
Background and Aim: Brucellosis has widespread prevalence and is one of the endemic diseases in our country, Iran. It is estimated that every year almost 500000 cases of Brucellosis - mostly Brucella Melitensis-occur in the world. Any type of brucellosis demands a specific treatment. Thus, this study was conducted to compare reduction of Brucellosis anti-antibody level in the serum one year after treatment with two regimens, i.e. Streptomycin + Doxycyclin and Rifampin + Doxycyclin. Materials and Methods: This experimental study was performed on 100 patients with Brucellosis based on the clinical findings wright ≥ 1/80 and 2ME ≥ 1/80. The cases were randomly divided into two groups one received Streptomycin + Doxycyclin (50 cases), and the other group was treated by Rifampin + Doxycyclin (50 cases). Then 3, 6 and 12 months after treatment Wright and 2ME tests were performed and their results compared by means of statistics using Chi-Square test. Results: The findings of the study showed that age of the cases ranged between 13 and 78 years and 46% of them were 39-48 years old. Results of the tests revealed no significant differences before treatment ,but immediately after treatment significant differences were observed in the two groups (Wright: P=0.05, 2ME: P=0.005) as in the first group tests tended to be negative more rapidly than in the second group. Wright’s test after 3 months showed significant differences in the two groups (P= 0.05) but there were no significant differences at 6 and 12 months following treatment. Conclusion: Regarding the rapidity of negative titers of tests in the first group immediately and 3 months after treatment, it could be inferred that Streptomycin regimen leads to a more effective treatment with rapid recovery which is also accompanied by reduction in the disease anti–antibody level in the serum.

Evaluation of diagnostic validity of Wright's serologic test in Brucellosis
M Seyednozadi, Dr Mr Erfanian,
Volume 16, Issue 3 (10-2009)
Abstract

  Background and Aim: Brucellosis is one of the most important worldwide zoonoses, which is endemic in many areas of Iran. As clinical findings are various and confusing in brucellosis simple, inexpensive and valid laboratory tests would be helpful to diagnose the infection. This study aimed to evaluate the validity of Standard common serological test (Wright’s) in the diagnosis of brucellosis.

  Materials and Methods: In this study, 340 patients with diagnosis of brucellosis were randomly selected from admitted patients in infectious disease ward, and Wright’s serologic test was studied. The sensitivity of Wright’s test was calculated according to the basis of 1/160 and 1/80 titers. For calculating the specificity of this test according to the basis of 1/160 and 1/80 titers, 160 non-brucellosis patients with Wright’s test results were selected as a control group.

  Results: Out of 340 patients, 53.8% were male and 46.2% were female and from 160 controls, 52.7% were male and 47.3% were female. The sensitivity of Wright’s test was 91.8% and 80.6% based on 1/80 and 1/160 titers, respectively. The specificity of Wright’s test was 97.5% and 100% based on 1/80 and 1/160 titers, respectively.

Conclusion: According to the obtained results, it should be stated that Wright’s test, which commonly is used in epidemiologic and diagnostic studies, has a significant validity and still can be used as a screening test based on 1/80 and as a diagnostic test based on 1/160 titer. It is obvious that other laboratory tests and if necessary, culture, may be used for definite diagnosis.
Brucellosis Spondylodiscitis: A case report
Nasrin Milani, Reza Ahmadi,
Volume 27, Issue 3 (9-2020)
Abstract
Brucellosis is an endemic disease in Iran that is transmitted from animal to human. The clinical manifestations of brucellosis are nonspecific and its complications involve bones and joints. Brucellosis osteomyelitis can mimic the manifestations of neoplasms; therefore, it cannot readily be diagnosed in some cases. Under such circumstances, high incidence can be a helpful factor.
We reported a 49-year-old man patient who presented with chronic musculoskeletal pain in the lower back. Initially, he was treated for osteoarthritis due to several negative serological tests for brucellosis. He was referred to a specialized clinic with no recovery achievement after 5 months treatment. The musculoskeletal pain together with the patient’s occupation (animal husbandry), was resulted in a high clinical suspicion of brucellosis. Consequently, the patient underwent another serological test and Magnetic resonance imaging (MRI). He was diagnosed with brucellosis-induced spondylodiscitis by positive serology result and bone involvement on MRI. Regular treatment was then started, which led to clinical and radiological improvement at the end.
With regard to chronic symptoms of the disease and despite the negative results of serological tests, it is recommended that radiological diagnostic methods such as MRI should be adopted in cases where there is a clinical suspicion of brucellosis.
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