Showing 5 results for Arthritis
N Saadati, A Fazlinejad, H Falsolieman, M Mosavi,
Volume 16, Issue 4 (12-2009)
Abstract
Background and Aim: Cardiovascular disorders are the most common cause of premature deaths in patients with rheumatoid arthritis (RA). This study dealt with echocardiographical findings in patients with rheumatoid arthritis.
Materials and Methods: Forty patients with established diagnosis of RA for more than five years, who lacked any known cardiovascular and brain symptoms, were enrolled in the study. After complete physical examination electrocardiogram, Chest X-ray, and echocardiography were performed .The obtained data was analysed using SPSS software and appropriate statistical tests..
Results: Mean age of the subjects was 46/2±15/48 and 90% of them were females. The most common valvular disorders were tricuspid and mitral valve regurgitation (72.5% and 52%, respectively). In 70% of the patients diastolic function was normal and there was a significant relationship between systolic function and diastolic abnormality (P=0.047). Pulmonary hypertension was detected in 40% of the cases. Surveying diastolic indices and Doppler echocardiography revealed a significant relationship between initial diastolic wave rate starting from mitral valve annulus and the diastolic wave rate in the right upper pulmonary vein and a significant relationship between the systolic wave rate originated from mitral valve annulus and the systolic wave rate in the right upper pulmonary vein (P=0.001 and P=0.047, respectively). However, there was not a significant relationship between terminal diastolic wave rate starting from mitral valve annulus with terminal diastolic wave rate of mitral valve and an insignificant relationship of the systolic wave rate of the right upper pulmonary vein with initial diastolic wave rate of mitral valve (P=0.43 and P=0.84, respectively).
Conclusion: A wide and frequent variety of cardiovascular disorders, especially pulmonary hypertension, diastolic dysfunction, and tricuspid and mitral regurgitations in RA patients, require special attention.
Ali Shahraki, Zahra Zakeri, Mahdiye Hosseinian, Salah Hajnegad,
Volume 21, Issue 1 (5-2014)
Abstract
Background and Aim: Limited studies have been focused on the role of IL-33 and IL-18 in Rheumatoid arthritis (RA).This study was done to measure the levels of IL-18 and IL-33 in the serum of patients with RA, before treatment, three month after treatment and compare to patients with osteoporosis as well as healthy controls. Materials and Methods: Sera were obtained from 20 patients with RA before treatment, 15 patients with osteoporosis and 30 healthy controls that have been matched to patients group. IL-33 and IL-18 levels were measured using ELISA assay. Results: Serum levels of IL-33 were significantly higher in patients with RA before treatment 5.47± 0.142 (pg/ml) versus three months after treatment 4.34±0.072, P=0.001, and control subjects 4.53±.076 (pg/ml), P=0.000. There were significant differences between IL-33 serum levels in patients with RA before treatment compare to osteoporosis subjects before treatment (5.47± 0.142 versus 3.65±0.08, P=0.000). The serum IL-18 levels of the RA patients before treatment 482.12±67.38 (pg/ml) were significantly higher than the IL-18 level three months after treatment 302.67±55.33 (pg/ml) P=0.004, the control group 216.19±47.56 (pg/ml) P= 0.004 and patients with OP 316.79±53.72, p= 0.001. Conclusion: Our results showed that IL-33 and IL-18 are highly active in RA and these cytokines might be closely involved in the pathologic mechanisms of the disease.
, Ensiyeh Norozi, Mitra Moodi, Hakimeh Malakimoghadam,
Volume 25, Issue 4 (12-2018)
Abstract
Arthritis is the most common disease among the elderly. Identification of factors affecting the prevention of arthritis prevention behaviors for the design of preventive interventions it is very important. This study aimed to investigate the factors affecting the prevention of arthritis in middle-aged women using the health belief model.
This descriptive-analytic study was performed on 325 women aged 59-29 years. The population of the study consisted of middle-aged women referred to health centers in Birjand who were randomly selected. Data were gathered through a researcher-made questionnaire.the questionnaire consisted of demographic information, health belief model constructs and knowledge questions and its validity and reliability were confirmed. Data were analyzed by SPSS software (version 19) using stepwise regression test.
The Average age of women studied 39.1 ± 8.4 years. The results of the study showed that 19.1% of subjects had good performance in terms of prevention of arthritis, 36% had moderate performance and 44.9% had poor performance. The most important predictors were self-efficacy (β = 0.37, P <0.001), knowledge (P = 0.26, P <0.001), and finally, perceived severity (β = 0.18, P <0.001). In total, these structures were able to predict 18.1% of the changes in behavioral prevention.
According to the results of the study, most women do not take preventive measures of arthritis, therefore, it is suggested that through educational interventions, awareness, perceived severity, and self-efficacy of individuals should be strengthened to promote the preventive behaviors of arthritis.
Maryam Mohammadi, Gholamreza Anani Sarab, Mohammad Hossein Ghaini, Roya Yaraee,
Volume 27, Issue 1 (3-2020)
Abstract
Background and Aim: Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disease that affects synovial tissue. According to potential side effects of current treatments, interest in using complementary and alternative medicine(CAM) has reappeared.The purpose of this study was to evaluate the effect of extract of Ferula assa-foetida L. resin on the severity of rheumatoid arthritis symptoms which is caused by collagen.
Materials and Methods: In this experimental study, 30 female Wistar rats were randomly divided into 6 groups: healthy control, CIA, Dexamethasone receiving group to amount 1 mg/kg, receiving group to 100 mg/kg concentration of extract of asafoetida resin, receiving group to 300 mg/kg concentration of extract of asafoetida resin and receiving group to 100 mg/kg extract and dexamethasone (mixed group). Rheumatoid arthritis was induced by the administration of collagen type 2 and adjuvant. The clinical evaluation started and the severity of the symptoms of rheumatoid arthritis, by examination and standard scoring was performed.
Results: From the thirteenth day, Symptoms of the disease appeared and from the fourteenth day, there was a significant difference between the control and CIA groups in the clinical symptom score of arthritis. Among intervention groups, receiving group to 100 mg/kg concentration of extract earlier and more cause to decreased severity of symptoms. So on the 28th day, disease severity in the control group was 13.4 and in the treatment group with a concentration of 100 mg/kg extracts of Ferula assa-foetida L. resin was 9.6.
Conclusion: Hydroalcoholic extract of asafoetida resin, its could reduce the severity of symptoms of ankle RA and in the dose of 100 mg/kg cause to mitigate the symptoms of apparent swelling and inflammation.
Zeinab Saremi, Tahereh Fakharian,
Volume 27, Issue 4 (12-2020)
Abstract
Celiac disease is one of the most common autoimmune diseases with a prevalence rate of 0.5-1% in the total population. Diagnosis has increased in recent years; however, many cases of the disease still seem to be diagnosed late. Although the rheumatic manifestations of celiac disease are not uncommon, they are often overlooked. A 30-year-old female patient referred to the rheumatology clinic of Valiasr Hospital, Birjand, Iran, with swelling of the fingers and knees joints. Despite treatment with corticosteroids and anti-rheumatic medications for the past two years that modulated the immune system, migratory inflammatory arthritis was still present. Serologic tests were performed on the patient, and she underwent endoscopy and duodenal biopsy. The celiac disease diagnosis was confirmed for the patient, and the joint symptoms improved significantly following a gluten-free diet. Rheumatologic manifestations of celiac disease can be the primary symptoms of the disease, and a gluten-free diet prescribed for these patients can relieve the symptoms to a large extent.
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