Showing 7 results for Shariati
M. Keshavarz, M. Shariati, Gr. Babaee,
Volume 15, Issue 3 (October 2008)
Abstract
Background and Aim: According to various studies, obese women, have an increased risk of a number of pregnancy complications and adverse pregnancy outcomes. Worryingly, the prevalence of obesity is rising during pregnancy. The present study was done to determine the incidence of obesity and its relationship to pregnancy complications. Materials and Methods: In this prospective study, all pregnant women in their early stage were referred to women’s clinic of Fatemiyeh Hospital by all health care centers and private clinics as soon as diagnosed. Obesity was defined as having a body mass index (BMI) of ≥30 kg/m² or more. So, pregnant women were divided into obese and non-obese cases according to BMI. All the women had no previous systematic diseases and received routine prenatal care until their labor. Demographic and pregnancy data were obtained on arrival and were recorded in special files and the cases’ economic status was determined by means of a special checklist. The obtained data was analysed by means of non-parametric variance analysis of, chi-square, Fisher exact t- test, Mann Whitney U, linear regression, and correlation co-efficient and P≤0.05 was taken as the significant level. Results: Totally 1194 pregnant women were studied. Prevalence of obesity was %13 (162 pregnant women). Obese women were older and had more childbirth. According to variance analysis and confounding factors including age and parity, obesity was found to be an independent factor in the occurrence of pre-eclampsia (P<0.001), gestational hypertension (P<0.01) and hydramnios (P<0.001) as well. Cesarean rate in obese women was greater and significant (P<0.001). Conclusion: Results confirmed that despite appropriate prenatal care, obesity was associated with an increase in pregnancy complications. So in order to improve the quality of care, pre-conceptual care is recommended. Weight losing, as an easy and inexpensive procedure in women who refer to the health centers to receive health care and family planning service, is essential and is recommended.
Masoume Vakili Azghandi, Mohammad Reza Nassiri, Ali Shamsa, Mohsen Jalali, Mohammad Mahdi Shariati,
Volume 22, Issue 2 (July 2015)
Abstract
Background and Aim: The Y-chromosome azoospermic factor (AZF) regions consist of genes whose specific roles and functions in spermatogenesis and fertility have not been completely clarified. Hence, recognition of the association between AZF microdeletions and male infertility has suggestions for the diagnosis, treatment, and genetic counseling. The main objective of the present study was investigation of Y chromosome microdeletions in the non-obstructive azoospermic and oligospermic patients in Mashhad and identification of appropriate STS markers associated with azoospermia and oligospermia. Materials and Methods: This descriptive-analytical study was performed on 45 infertile men with azoospermia and oligospermia with normal karyotypes referred to infertility center of Montaseriyeh hospital in Mashhad. Molecular screening technique was performed by using Multiplex PCR and sequence-tagged sites (STS) primers according to the EAA/EMQN guideline for detection of microdeletions in Y-chromosomal AZF regions and the Y specific sequences. Results: Three out of 45 infertile men had deletions in the AZFc and AZFa regions. Among every 3 infertile men, two patients (7.7%) and one patient (5%) had microdeletion in the AZFc region and in the AZFa, respectively. The results indicated that AZF microdeletions had a significant effect on azoospermia and oligospermia in infertile men. Conclusion: Y-chromosome microdeletion analysis can be recommended as an important molecular test for infertile males to obtain reliable genetic information before the administration of assisted-reproductive techniques. It will help to decrease the cost and technical difficulty of the procedure.
Ahmad Amouzeshi, Hadi Shariatifar, Seyyed Ebrahim Hosseini,
Volume 28, Issue 1 (April 2021)
Abstract
Background and Aims: Various therapies and surgeries are applied in heart valve surgery, including interrupted and semi-continuous suture techniques. Therefore, this study aimed to compare the clinical implications of two methods of interrupted and semi-continuous suture techniques during and after mitral or aortic valve replacement surgery among patients referred to Department of Surgery, School of Medicine, Birjand University of Medical Sciences.
Materials and Methods: In this study, the required information of patients was collected through the checklist based on the objectives of the study. The subjects had undergone aortic or mitral valve replacement for heart valve replacement suturing with continuous or interrupted suturing techniques. The patients' records were examined to investigate the complications, and in case that the required information was not registered, the patient or his relatives were also contacted so that the patient could be examined and referred to the hospital by the patient's surgeon.
Results: The mean age scores of patients undergoing surgery in the continuous and interrupted suture groups were obtained as 53.06±13.48 and 52.86±12.97 years, respectively. It was revealed that there was a large distribution of heart valve leakage, arrhythmia, heart attack, valve infection, involved valve type, and aortic and mitral valve size in the two groups; however, there was no significant difference (P>0.05).
Conclusion: Based on the results of this study, the rate of cardiac function and complications caused by the two techniques of continuous and interrupted suturing were not significantly different from each other; therefore, these two methods were not superior to each other due to the mentioned cases.
Mehrnoush Ghavami, Mehrdad Shariati, Davood Moghadamnia,
Volume 29, Issue 1 (April 2022)
Abstract
Background and Aims: Cadmium chloride causes renal dysfunction. The present study aimed to investigate the protective effects of hydroalcoholic extract of Alcea rosea aerial parts on cadmium chloride-induced renal dysfunction in male rats.
Materials and Methods: In this experimental study, 54 adult male Wistar rats were assigned to six groups (n=9 in each group). The control group, the sham group1, received 0.2 ml of distilled water as solvent. Sham group 2 received 2 mg/kg cadmium chloride intraperitoneally (IP) for 21 days. Experimental groups 1, 2, and 3, respectively, received 2 mg/kg cadmium chloride IP for 21 days, followed by 150,300, and 450 mg/kg hydroalcoholic extracts of aerial parts of Alcea rosea intraperitoneally for 30 days. At the end of the experiment, blood samples were taken from all animals to measure levels of sodium, potassium, blood urea nitrogen (BUN), creatinine, and uric acid. The data were analyzed in SPSS software (version 18) using one-way ANOVA and Tukey post hoc test.
Results: The mean serum concentrations of creatinine, BUN, sodium, potassium, and uric acid in all experimental groups showed a significant decrease, as compared to those in sham group 2 (P<0.05).
Conclusion: Based on the results, hydroalcoholic extract of aerial parts of Alcea rosea may improve cadmium chloride-induced renal dysfunction in male rats.
Mehrnoush Ghavami, Mehrdad Shariati, Davood Moghadamnia,
Volume 29, Issue 2 (Aug 2022)
Abstract
Background and Aims: Passiflora caerulea has antioxidant properties. The present study aimed to assess the effects of hydroalcoholic extract of Passiflora caerulea aerial parts on cadmium chloride-induced renal dysfunction in male rats.
Materials and Methods: In this experimental study, 54 adults male Wistar rats 200±10 gr were divided into 6 groups (N=9). Control group, the sham group that received 0.2 ml/kg of distilled water as solvent. Renal Injury induction group: received 2 mg/kg cadmium chloride intraperitoneally (IP) for 21 days. Treatment groups 1, 2, and 3, respectively, received 2 mg/kg cadmium chloride IP for 21 days, followed by 150, 300, and 450 mg/kg hydroalcoholic extracts of aerial parts of Passiflora caerulea intraperitoneally for 30 days. At the end, blood samples were taken from all animals. Serum levels of sodium, potassium, Blood Urea Nitrogen (BUN), creatinine and uric acid were measured. Data were analyzed using SPSS 18, ANOVA and Tukey test.
Results: Cadmium chloride caused a significant increase in serum concentrations of creatinine (P<0.001), BUN (P<0.001), sodium (P<0.001), potassium (P=0.04) and uric acid (P<0.001) compared to the control group. Different amounts of hydroalcoholic extract of aerial parts of Passiflora caerulea could significantly reduce serum concentrations of creatinine (P<0.001), BUN (P<0.001), sodium (P<0.001), potassium (P<0.001) and uric acid (P<0.001)in all treatment groups compared to cadmium chloride.
Conclusion: As evidenced by the obtained results, the hydroalcoholic extract of aerial parts of the Passiflora caerulea plant has a protective effect on cadmium chloride-induced renal dysfunction in male rats.
Mahnaz Dehghani, Mehrdad Shariati, Davood Moghadamnia,
Volume 29, Issue 3 (October 2022)
Abstract
Background and Aims: Vitamin D has antioxidant and anti-inflammatory activities. The present study aimed to investigate the protective effect of vitamin D on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), testosterone hormones and testicular tissue changes induced by methotrexate in adult male rats.
Materials and Methods: In this experimental study, 30 adult male Wistar rats weighing 230-260 g were divided into six groups (n=5). Control group: They received no extract or solvent, sham group: 1 ml of distilled water as a solvent, treatment group 1: methotrexate (5 mg/kg) (gavage), treatment group 2: vitamin D (1000 IU/kg), treatment group 3: methotrexate (5 mg/kg) + vitamin D (500 IU/kg), and treatment group 4: methotrexate (5 mg/kg) + vitamin D (1000 IU/kg). After 28 days of treatment in the form of gavage, blood was taken directly from the heart to measure the serum concentration of LH, FSH, and testosterone hormones. The testes were removed and tissue changes were examined with hematoxylin-eosin staining. The collected data were analyzed using SPSS (version 18), one-way analysis of variance, and post hoc Tukey's test.
Results: In the group receiving methotrexate, the level of testosterone hormone, the number of spermatogonia (P>0.001), spermatocytes (P>0.001), sperm (P>0.001) and Leydig cells (P>0.001) decreased and the serum level of LH (P>0.001) and FSH (P>0.001) increased significantly compared to the control and sham groups. In groups receiving methotrexate + vitamin D, vitamin D was able to compensate for the adverse effects caused by methotrexate.
Conclusion: Our results showed that vitamin D could improve LH, FSH, testosterone hormones, and testicular tissue changes induced by methotrexate in adult male rats.
Mandana Arabi, Mokhtar Mokhtari, Mehrdad Shariati, Davood Moghadamnia,
Volume 30, Issue 2 (October 2023)
Abstract
Background and Aims: Melon seeds have estrogenic, anti-cancer, anti-diabetic, anti-obesity, and antioxidant effects. The present study aimed to investigate the effect of the hydroalcoholic extract of melon seeds on the pituitary-gonadal axis and the tissue changes of the testis in adult male rats.
Materials and Methods: In this experimental study, 50 adult male Wistar rats weighing 210-230 g were assigned to five groups (n=10). The Control group received no extract or solvent; Sham group: 1 ml of distilled water as a solvent; experimental group 1: Melon seed extract (50 mg/kg), experimental group 2: Melon seed extract (100 mg/kg), Experimental group 3: Melon seed extract (150 mg/kg). After 21 days of treatment by the intraperitoneal method, blood was taken from the animals. The serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured by radioimmunoassay (RIA). Thereafter, the testicles were removed, and tissue changes were examined by hematoxylin-eosin staining. The collected data were analyzed in SPSS software (version 18) using a one-way analysis of variance and post hoc Tukey's test.
Results: The mean body weight in experimental groups 2 and 3 demonstrated a significant decrease compared to the control and sham groups (P<0.001). The mean weight of the testes in experimental groups 2 and 3 displayed a significant increase compared to the control and sham groups. The mean concentration of testosterone hormones, FSH, LH, the number of spermatogonial cells, primary spermatocytes, spermatids, Sertoli, and Leydig cells, as well as the number of sperm cells in experimental group 3, had a significant increase compared to the control and sham groups (P<0.001).
Conclusion: As evidenced by the results of this study, the hydroalcoholic extract of melon seeds had stimulating effects on the pituitary-gonadal axis and testicular tissue in adult male rats.
*Corresponding Author: Davood Moghadamnia; Emails: davood.moghadamnia@gmail.com
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