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Showing 4 results for Roghani
Evaluation of correaltion between plasma homocysteine and oxidized low-density lipoprotein in patients with coronary artery disease
K Ghatreh Samani, F Roghani, E Farrokhi,
Volume 16, Issue 3 (October 2009)
Abstract

  Background and Aim: Cardiovascular diseases (CVD), especially coronary heart diseases (CHD) are major causes of death in developed countries. Studies have been shown that total plasma homocysteine (tHcy) has been associated with an increased risk of CHD, probably a causal type. A lower tHcy concentration will reduce the frequency of CHD. The aim of this study was to evaluate the correlation between tHcy and CHD and its relationship with other CVD risk factors such as oxidized low density lipoprotein (ox-LDL).

  Materials and Methods: A total number of 260 patients with coronary angiography indication were included in this case control study. The study group consisted of 130 patients with at least one vessel stenosis greater than 50% and the control group consisted of 130 normal angiogram without stenosis. Total Hcy, cholesterol, triglyceride, high density lipoprotein (HDL) and its sub fractions, low density lipoprotein (LDL) and ox-LDL were measured in two groups. Data were analyzed by SPSS using relevant statistical tests at the significant level of P<0.05.

  Results: The mean serum tHcy level in CVD patients (19.25±8.20 µmol/L) was significantly higher (P<0.001) than the control group (14.8±4.17 µmol/L). Moreover, among patients with CVD, a positive significant correlation between tHcy and ox-LDL level in plasma, was found (r=0.426, P<0.001). Despite reduced HDL2 concentration in patients with CVD than the control group no significant correlation between high tHcy and low HDL2 was achieved in this study.

Conclusion: Beside other known effects, homocysteine may also act as a risk factor for cardiovascular diseases by increasing plasma ox-LDL concentration.
The effect of chronic silymarin on serum level of some enzyme markers and tissue level of malondialdehyde in diabetic rats
Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Farshad Roghani Dehkordi,
Volume 19, Issue 1 (April 2012)
Abstract

Background and Aim: Diabetes mellitus causes enhanced oxidative stress due to increased production of oxygen free radicals and decreased activity of antioxidant defense system. Flavonolignan Silymarin has an antidiabetic effect. This study was conducted to evaluate the effect of its chronic administration on serum levels of aspartate and alanine aminotranferase and the heart and liver level of malondialdehyde. Materials and Methods: In this experimental study, 40 male Wistar rats were divided into 5 equal groups, i.e. control, Silymarin -treated control (100 mg/kg), diabetic, and two Silymarin- treated diabetic groups (50 and 100 mg/kg). Silymarin was daily administered (i.p.) to each of the group members ten days after streptozotocin injection for 4 weeks. Serum levels of aspartate and alanine aminotranferase were measured both before and at the end of the study. In addition, level of malondialdehyde (MDA) was measured in the liver and the heart tissues on the basis of the reaction of thiobarbituric acid. Results: Serum glucose level in high dose Silymarin-treated diabetic group was significantly lower as compared to diabetics in the sixth week (P=0.007).Moreover, diabetic rats showed a significant increase in their aspartate serum level (P=0.028) and alanine aminotranferase (P=0.008) and Silymarin treatment only significantly reduced serum level of alanine aminotranferase (P=0.034). In addition, diabetes was followed by increased level of MDA in the liver (P=0.008) and the heart (P=0.009) tissues and high-dose Silymarin treatment significantly reduced MDA level only in the liver tissues (P=0.026). Conclusion: Long-term treatment with silymarin at a dose of 100 mg/kg can attenuate serum level of alanine aminotranferase and hepatic MDA level and does not have any significant effects on serum level of aspartate aminotranferase and cardiac tissue level of MDA in the administered doses


Effect of acetyl L carnitine on oxidative stress markers in hippocampus of epileptic rat
Mehrdad Roghani, Zahra Kiasalari, Mohsen Khalili, Farzane Pesaran,
Volume 20, Issue 1 (April 2013)
Abstract
 Background and Aim: Epilepsy is a rather common neurological disorder. Oxidative stress plays an important role in the pathogenesis of epilepsy. The present study was undertaken to evaluate the effect of acetyl L carnitine (ALC) on oxidative stress markers in hippocampus of epileptic rat. 

Materials and Methods: In this experimental study, male rats were divided into sham, epileptic, valproic acid-treated epileptic ones at a dose of 200mg/kg, and 3 ALC-treated epileptic groups at doses of 50 and 100mg/kg for 3 days pre-surgery. Seizure activity was determined in 4 h periods and for measurement of oxidative stress markers, level of malondialdehyde (MDA), nitrite, and activity of superoxide dismutase (SOD) were determined in hippocampal homogenate. The obtained datawas fed into SPSS software (V:16) and for statistical analysis, one-way ANOVA and x2 tests were used.

 Results: ALC treatment at doses of 50 and 100 mg/kg attenuated seizure intensity (P<0.05 and P<0.01, respectively), level of MDA significantly reduced (P<0.05) following ALC at a dose of 50 mg/kg, but nitrite level and SOD activity did not show significant changes. 

Conclusion: ALC pretreatment has antiepileptic activity and at a dose of 50 mg/kg can reduce MDA level as an index of lipid peroxidation but it has no appropriate effect on nitrite level and SOD activity.


Evaluation of low doses of Azathioprine in reducing relapse and corticosteroid dependence in patients with Ulcerative Colitis
Maryam Rezaiee, Hasan Salman-Roghani, Meisam Sargazi, Fatemeh Mahdizadeh,
Volume 26, Issue 2 (July 2019)
Abstract
Background and Aim: Ulcerative Colitis is an idiopathic inflammatory bowel disease that is common in adults. Although corticosteroids are the most effective preservative treatment for Ulcerative Colitis. However, due to the dependence of these drugs and their serious complications, the use of an immunosuppressive drug or surgery should be taken seriously. Thus the aim of the study was the evaluation of the efficiency of low doses of azathioprine (AZA) in reducing relapse and corticosteroid-dependence in Ulcerative colitis patients.
Materials and Methods: In this cross-sectional study, 96 patients with ulcerative colitis were followed for one year. Patients who indicated by corticosteroid therapy not able to reduce the dose of corticosteroid, at second relapse was treated with 1- 1.5 mg/kg of (AZA). Demographic characteristics, the severity of disease at the beginning of the study and response to treatment, recurrence of the disease, and drug side effects during the study. Data were analyzed using the Chi-square test in SPSS software.
Results: At the beginning of the study, over 50% of patients had high symptoms of the disease. In the patients under study, 40 (41.7%) patients had corticosteroid dependence, all of them being treated with (AZA). Of the 96 patients during the one-year follow-up 24 patients are relapses and 72 patients did not have relapses. 97.8% of corticosteroid patients with (AZA)prescription, Corticosteroid was discontinued and only one patient did not response to AZA and was underwent surgery.
Conclusion: Given the prevalence of use of corticosteroids, prescription of low doses of (AZA) can be considered as one of the effective therapies to reduce the rate of relapse of the disease and to avoid frequent use of corticosteroids.

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