Showing 6 results for Mortazavi Moghaddam
Ghr. Mortazavi Moghaddam, A. Zarban,
Volume 12, Issue 1 (April & July 2005)
Abstract
Background and Aim: Magnesium is required for a wide variety of cellular activities.In this study we follow the effect of intravenous Magnesium Sulfate used for the treatment of acute asthma.
Materials and Methods: In this clinical trial, which was undertaken in the emergency ward of Vali-e Assre Hospital under BUMS, 37 Patients with acute asthma and Fischle Severity Score (FSS) ≥ 4 at arrival were enrolled. All the patients received 2 puffs of salbutamol spray, 300mg of IV hydrocortisone and 5 lit/min nasal O2. After informed consent of the subjects to an additional treatment, they were randomly divided into two groups namely "case" and "control". The "case" was treated by 1.2 g intravenous magnesium sulfate and the "control" received placebo. After the administration, FSS was determined at 20, 40, and 60 minute intervals. The obtained data were analyzed employing statistical tests, i-e T-test, Chi-Square, and Wilcoxon
rank-sum test at the significant level P≤0.05.
Results: The 37 patients were randomly grouped into 19 (cases) and 18 (control). The mean Mg serum level was 2.19±0.50mg/dl in the cases and 2.23±0.51mg/dl in the controls (P>0.05). FSS before and after 1-hour treatment dropped from 4.84±0.76 to 4.39±0.53 in the cases but it decreased from 4.6±0.52 to 3.7±0.56 in the control group. Statistic analysis showed the reduction in FSS in the cases and controls; 1.39±0.64 and 0.67±0.32, respectively (P<0.05). The therapeutic response time of 26.3% of the cases was 20 minutes compared to 0% of control group (P<0.05).
Conclusion: Administration of 1.2 g of IV magnesium sulfate accelerates the improvement of the clinical symptoms when used as an adjunct to standard therapy in patients with severe, acute asthma.
Gh Mortazavi Moghaddam,
Volume 15, Issue 2 (July 2008)
Abstract
While pulmonary thromboembolism is common, thromboembolic pulmonary hypertension is very rare. The present case is a 35 year old woman with chronic thromboembolic pulmonary hypertension, who presented with severe dyspnea and leg edema, following an earlier thrombotic event of 10 years earlier, after her her second childbearing. She also had a history of the first childbearing complicated with congenital heart disease and death of her infant by the age of 5 months. Despite conventional treatments for pulmonary thromboembolism including anticoagulants, her condition developed to severe pulmonary hypertension. The investigations including spiral CT confirmed bilateral pulmonary artery thrombosis, positive antiphospholipid antibody and negative serologic tests for rheumatic disease. Besides, the patient showed no symptoms of systemic vasculitis. Therefore, it was diagnosed that the patient had primary antiphospholipid syndrome without underlying rheumatic disease. Thus, the patient was referred to a thoracic surgeon for endarterectomy because of severe pulmonary hypertension (105 mlHg). However, due to extensive bilateral thrombotic involvement of pulmonary artery, surgical treatment was refused. Treatment with prednisolone 60mg/d and warfarin with high dose was carried out. The clinical condition was improved and dyspnea, edema and general condition recovered. The probable role of this syndrome in the development of chronic thromboembolic pulmonary hypertension, neonatal congenital heart disease, and also therapeutic strategies will be discussed in this report.
S.gh. Mortazavi Moghaddam, A. Zarban,
Volume 16, Issue 2 (July 2009)
Abstract
Background and Aim: Smokers are exposed to significant quantities of oxidative factors. The effects of smoking on plasma concentrations of antioxidants and susceptibility to oxidative stress in young subjects are largely unknown. This study was done for comparison of uric acid concentration and plasma antioxidant capacity in young smokers and non-smokers. Materials and Methods: In an analytical observational study, a sample of 23 male smoker with history of at least 10 cigarettes per day for 5 years and 21 healthy non smoker male, all aged 40 or under 40 years old, were included voluntarily in the study. All participants were free of major signs and symptoms suggestive of any disease. Fasting blood samples (10 ml) were collected in heparinized tubes just before morning smoking. Plasma samples were isolated and stored at -60°C for later evaluating. In this study, uric acid concentration was measured by an enzymatic method. The main methods for evaluation of oxidative stress were: determination of the Total Antioxidant Capacity (TAC) by Ferric reducing/antioxidant power (FRAP) assay, Ellman's reagent for measuring the amount of thiol groups, and concentration of 2,2-Diphenyl-1-picrylhydrazyl (DPPH) for determination of antiradical activities of plasma. Results: Uric acid concentrations (mg/dL) in smokers and non-smokers was 6.2±1.5 and 4.5±1.7 respectively (P<0.001). Determination of the TAC (µmol/L) level by FRAP assay showed 980.7±214.4 in smokers and 997.4±156.9 in nonsmokers (P=0.75). Quantitative determination of per-oxiradicals by DPPH assay revealed 12.6%±1.4 in smoker and 15.3%±2.2 in nonsmoker (P=0.37). The plasma levels of thiol groups (mmol/L) were 281.1±60.9 in smokers and 256.5±57.8 in non-smokers (P=017). Conclusion: Given the role of cigarette smoking as a risk factor for cardiovascular diseases and the role played by oxidative stress in them, measurement of uric acid in young smoker subjects represents a marker against tobacco-induced oxidative stress and recommends their timely giving up of smoking.
Sayyed Gholamreza Mortazavi Moghaddam, Fatema Amirian,
Volume 23, Issue 4 (January 2016)
Abstract
Background and Aim: Continuous evaluation of educational activities plays a critical role in the promotion of educational programs. The present study aimed at assessing the viewpoint of medical students on the effectiveness of educational programs and regulations in clinical training.
Materials and Methods: A cross-sectional and descriptive-analytical study was conducted in the internal medicine ward in vali-e-asr hospital of Birjand University of Medical Sciences. All medical students were selected via census from those who had passed their internal medicine training over the past 2 years (2014-2016). Viewpoint of the students on the effectiveness of the internal medicine ward regulations and educational programs were evaluated by means of a researcher-designed questionnaire. The questionnaire included 10 questions regarding educational regulations and 26 items about educational programs. Finally, the obtained data was fed into SPSS (V: 16) software using independent T-test for analysis at the significant level of alpha=0.05.
Results: A total of 100 students, including 36(36%) interns and 64(64%) stagers filled out the questionnaires. Mean viewpoint score of the students on educational regulations was 2.66±0.86. Mean viewpoint score of students on educational rules affecting attendance of students and instructors in training fields was 3.25±1.22 and 3.23+1.09, respectively. Regarding the educational programs, the highest and lowest scores belonged to the outpatient clinic ground conferences; (3.31±0.74) and (2.84±0.79), respectively.
Conclusion: A polyclinic can be an appropriate spot to transfer clinical-educational programs, but ground conferences are not considered suitable for stagers and interns. Running educational regulations can gurantee more attendance of students and instructors in clinical training.
Seyyed Gholamreza Mortazavi Moghaddam, Hosein Gazi,
Volume 26, Issue 4 (January 2019)
Abstract
Background and Aim: Considering the cost and some limitations in measuring the percentage of expiratory volume in the first second (FEV1%), This study was performed to determine the relationship between oxygen saturation percentage (SPO2%) with expiratory volume in the first-second (% FEV1) in patients with chronic obstructive pulmonary disease(COPD).
Materials and Methods: In a descriptive-analytical study, 25 women and 25 men with COPD were selected by Non-probability and simple sampling from patients referred to the outpatient clinic of Vali-e-Asr Hospital regardless of the severity of the disease. To measure of % FEV1, spirometry method and a finger pulse oximeter to measure SPO2 was used.Statistical tests including Pearson test and independent t-test and linear regression model were used.
Results: The mean patient age 63.18±10.47 years, average % FEV1 of 36.60 ± 16.15 and the mean SPO2% 84.20±5.35 was respectively. The correlation coefficient between% FEV1 and SPO2% was 0.36 (P=0.01). Mean of SPO2% in smokers and non-smoker was %82.67±5.22 and %86.50±5.29 respectively (p=0.02). Regression analysis in constant conditions showed %FEV1 By increasing one unit SPO2%, the amount of FEV1% with probability factor of 0.16 will be increased 0.36 (P=0.02).
Conclusion: The amount of SPO2% significant correlation at the medium level with the amount of %FEV1 and can predict to some extent FEV1%; Therefore, it has been diagnosed in people with obstructive pulmonary disease and it can be used for evaluation and follow-up of patients instead of spirometry.
Faezeh Naimi, Elahe Allahyari, Sayyed Gholamreza Mortazavi Moghaddam,
Volume 30, Issue 4 (Januray 2024)
Abstract
With the emergence of Corona disease in late 2019, the healthcare network was directly and indirectly affected, and the process and management of patients other than COVID-19 changed. To evaluate some of these changes, the present study was conducted on post-COVID-19 hospital admissions of patients who have been infected with Coronavirus in the past. The census method was used for patients’ recruitment. The collected data was analyzed using descriptive/analytical statistical methods. A total of 202 patients with a mean age of (57.60±18.73) years, including 109 (54%) women and 93 (46%) men, were recruited. The number and percentage of cases admitted in internal, infectious, neurology, and heart wards, were 63 (31%), 52 (25.7%), 35 (17.3%), and 31 (15.3%), respectively. No correlation was found between the history of hospitalization and the type of treatment specific to COVID-19 (Remdesivir) and the disease that led to re-hospitalization after recovery from COVID-19 (P=0.08). Regardless of whether receiving Remdesivir or not, post-COVID-19 hospitalization due to various reasons in internal and infectious wards was the most frequent, respectively, followed by cardiovascular events.
*Corresponding Author: Sayyed Gholamreza Mortazavi Moghaddam; Emails: gmortazavi@yahoo.com
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