Volume 19, Number 2 (July 2012)                   J Birjand Univ Med Sci. 2012, 19(2): 148-156 | Back to browse issues page


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Baharara J, Zafar-Balanezhad S, Nejad Shahrokh Abadi K, Hesami Z. The Synergic Effects of Atorvastatin (0/1m) and (10 m) and Extremely Low Frequency Electromagnetic Field on Angiogenesis. J Birjand Univ Med Sci.. 2012; 19 (2) :148-156
URL: http://journal.bums.ac.ir/article-1-911-en.html

1- Associate Professor Department of Biology, Mashhad branch, Islamic Azad University, Mashhad , baharara@yahoo.com
2- PhD Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
3- PhD Department of Biology, Mashhad Branch ,Islamic Azad University, Mashhad, Iran
4- Msc in Cell & Developmental Biology Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Abstract:   (10560 Views)
Background and aim: statins promote the proliferation and survival of endothelial cells. Angiogenesis is the formation of new blood vessels from pre-existing ones.It contributes to physiological and pathophysiological condition. In this research we used atorvastatin (0/1m) and (10m) with electromagnetic field on angiogenesis of chick embryo. Method: in this experiment study 98 Ross fertilized eggs were randomly divided in to 7 groups as: following:control group,1)group sham-exposed,2) group treated with atorvastatin (0/1 m), 3)group treated with atorvastatin (10m),4) group treated with electromagnetic field,5) group treated with both atorvastatin (0/1m) and electromagnetic field,6) group treated with both atorvastatin (10m) and electromagnetic field. In day2, a window was opened on eggs in sterile condition in days 8a gelatin sponge was placed on chorioalantoic membrane(CAM) and was soaked with 10l atorvastatin (0/1 m) and (10m) in groups (3,6) and groups (2 , 5) and groups (4,5,6) were placed in 50 Gauss magnetic field for 4 hours in day 10.In day 12,CAMs were examined and photographed by research photo-stereo microscope in all case. Data were analyzed statistically by t-test and ANOVA(P<0/05). Result: comparison between average umber and length of vessels in controls and sham-exposed didn’t show and significant differences (p>0/05).comparison between average number and length of vessels in control and group 2 and groups 3, 6 a significant increase and decrease was shown in the average number and length of vessels compared with control(p<0/05). Conclusion: the result of this study showed that: treated with atorvastatin 10m with electromagnetic field has an inhibitory effect on angiogenesis in CAM and was shown that electromagnetic field has an inhibitory on atorvastatin 0/1m to stimulatory effect on angiogenesis in CAM.
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Type of Study: Original Article | Subject: General
Received: 2011/08/26 | Accepted: 2012/06/13 | Published: 2016/03/10

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