Volume 17, Issue 2 (July 2010)                   J Birjand Univ Med Sci 2010, 17(2): 72-78 | Back to browse issues page

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Movahed F, Jalali S, Javadi A. Comparison of two regimes in administration of vaginal misoprostol(every 6 hours vs every 12 hours) for second trimester pregnancy termination. J Birjand Univ Med Sci. 2010; 17 (2) :72-78
URL: http://journal.bums.ac.ir/article-1-612-en.html
1- Assistant Professor, Department of Obstetrician & Gynecology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , drmovahed@yahoo.com
Abstract:   (24021 Views)

  Background and Aim: Progress in the diagnosis of fetal abnormalities and early diagnosis of maternal life threatening diseases has resulted in an increased number of second trimester pregnancy terminations. The present study aimed at comparing the therapeutic effects of two different regimens of vaginal misoprostol administration (i.e. every 6 hours vs every 12 hours) on the 2nd trimester pregnancy termination. ‏

  Materials and Methods: In this randomized clinical trial, 140 women with14-28 weeks of gestation who had volunteered to undergo termination of pregnancy for various indications, were randomly divided into 2 equal groups. The first group received 400µg vaginal misoprostol every 6 hours and the second one every 12 hours. If expulsion of fetus did not occur within 48 hours, high dose of oxytocin was administered. Induction-abortion interval, mean dose of misoprostol, high dose oxytocin administration need and side-effects in the two groups were recorded. The obtained data was analyzed using SPSS statistical software (version 12) at the significant level P<0.05.

  Results: There was no significant difference in the mean induction-abortion interval between the two groups. ‏ Average dose of misoprostol was higher (P<0.001) in the 6-hour group (1600±761 µg) compared to the 12-hour group (1200±385µg). There was not any need for administration of high dose of oxytocin in either of the groups. Incidence of fever was slightly higher in the 6- hour group, which was not statistically significant.

  Conclusion: For termination of second trimester pregnancy, administration of 400µg vaginal misoprostol every 12 hours can be as useful as every 6 hour administration of the drug.

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Type of Study: Original Article | Subject: Gynecology & Obstetrics
Received: 2010/05/13 | Accepted: 2016/03/10 | ePublished: 2016/03/10

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