Volume 29, Issue 2 (Aug 2022)
J Birjand Univ Med Sci. 2022, 29(2): 85-96 |
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Research code: IR.BIRJAND.REC.1400.013
Ethics code: IR.BIRJAND.REC.1400.013
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Jahed E, Mogharnasi M, Zarban A, Ghahremani R. Effect of four weeks home workout plan training and pomegranate supplementation on oxidative stress in overweight and obese postmenopausal women. Journals of Birjand University of Medical Sciences 2022; 29 (2) :85-96
URL: http://journal.bums.ac.ir/article-1-3142-en.html
URL: http://journal.bums.ac.ir/article-1-3142-en.html
1- Department of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran
2- Department of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran ,mogharnasi@birjand.ac.ir
3- Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
2- Department of Exercise Physiology, Faculty of Sports Sciences, University of Birjand, Birjand, Iran ,
3- Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Keywords: Home Workout Plan, Malondialdehyde, Menopause, Obesity, Overweight Pomegranate Supplementation, Total Antioxidant Capacity
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ABSTRACT
Background and Aims: Exercises and consumption of plant-based supplements are essential to prevent and control diseases. The present study aimed to investigate the effect of a four-week home workout plan and pomegranate supplementation on oxidative stress in overweight and obese postmenopausal women.
Materials and Methods: The present single-blind, quasi-experimental, and practical study was conducted on 60 overweight and obese women between 45 to 65 years with a body mass index over 25 (kg/m2) who were randomly divided into four groups. After participant dropout, 56 women were divided into four groups. The first group (n=15) took pomegranate supplements and had exercise, the second group (n=13) took the placebo and had exercise, the third group (n=14) was given the pomegranate supplement and the fourth group (n=14) was given the placebo. The intervention and placebo groups took a 225 mg capsule of pomegranate supplementation and placebo daily for four weeks, respectively. Resistance training was performed in 28 90-min training sessions for four weeks at home due to the Covid-19 pandemic.
Results: The results of the present study indicated that exercise and supplementation significantly increase total antioxidant capacity, and decrease Malondialdehyde (MDA) (P<0.05); however, no significant effect was observed in the other groups. One-way ANOVA demonstrated that four weeks of training and supplementation significantly reduce the concentration of MDA compared to the control group (P<0.05). However, no significant difference was observed among the four groups in the total antioxidant capacity.
Conclusion: Pomegranate supplementation together with a home workout plan can possibly reduce oxidative stress and prevent difficulties related to obesity.
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13- Kurkcu R. The effects of short-term exercise on the parameters of oxidant and antioxidant system in handball players. Afr J Pharm Pharmacol. 2010; 4(7): 448-52. DOI: 10.5897/AJPP.9000270
14- Tarverdizadeh B, Bedrous Oghoubian Salmasi M. The Effect of Interval Training on HSP70 and Some Inflammatory, Growth and Functional Markers among Women with Breast Cancer. Iran J Obstet Gynecol Infertil. 2016; 19(37): 16-24. [Persian] DOI: 10.22038/IJOGI.2016.8184
15- Akbarpour M, Fathollahi Shoorabeh F, Faraji F. Effects of eight weeks of resistance training and consumption of pomegranate on GLP-1, DPP-4 and glycemic statuses in women with type 2 diabetes: A randomized controlled trial. Nutr Food Sci Res. 2021; 8 (1): 5-10. URL: http://nfsr.sbmu.ac.ir/article-1-418-en.html
16- Esmaeilinezhad Z, Boldaji RB. The Effect of Pomegranate and Its Compounds on Breast Cancer. J Shahid Sadoughi Uni Med Sci. 2019; 27(8): 1814-25. [Persian] DOI: 10.18502/ssu.v27i8.2036
17- Mirazi N, Nosrati S, Hosseini A. Evaluation of pomegranate rind (Punica granatum) hydroethanolic extract on blood parameters in male mice treated by Irinotecan Hcl. Armaghan-e Danesh. 2015 May 15; 20(2): 114-26. [Persian] URL: http://armaghanj.yums.ac.ir/article-1-487-en.html
18- Zarban A, Malekaneh M, & Boghrati M. R. Antioxidant properties of pomegranate juice and its scavenging effect on free radicals. J Birjand Univ Med Sci. 2007; 14(3): 9-15. URL: http://journal.bums.ac.ir/article-1-149-en.html
19- Zarezadeh M, Saedisomeolia A, Hosseini B, Emami M R. The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial. Qom Univ Med Sci J. 2019; 13 (8): 14-25. DOI: 10.29252/qums.13.8.14
20- Akbarpour M, Fathollahi Shoorabeh F, Mardani M, Amini Majd F. Effects of Eight Weeks of Resistance Training and Consumption of Pomegranate on GLP-1, DPP-4 and Glycemic Statuses in Women with Type 2 Diabetes: A Randomized Controlled Trial. Nutr Food Sci Res. 2021; 8 (1): 5-10. URL: http://nfsr.sbmu.ac.ir/article-1-418-en.html
21- Hooshmand-Moghadam, B., Choobineh, S. Effect of Pomegranate Supplementation on Antioxidant Status in Young Women after Heavy Resistance Exercise. Journal of Animal Biology. 2017; 10(1): 101-12. [Persian] URL: http://ascij.damghaniau.ac.ir/article_538432.html?lang=en
22- Sori M, Kolivand M, Salari N, Bakhshi N. Investigating the relationship between regular exercise and menopausal symptoms in postmenopausal women. J Health. 2021; 12(1): 84-93. DOI: 10.52547/j.health.12.1.84
23- Farhadi H, Rahimi Fardin S, Baghaiee B. The effect of 8 week of pomegranate supplementation on inflammatory and muscular damage indices in over weight untrained men due todifferent intensity VO2max. Journal of Practical Studies of Biosciences in Sport. 2017; 5(9): 31-41. [Persian] DOI: 10.22077/JPSBS.2017.619
24- Cegielski J, Brook MS, Quinlan JI, Wilkinson DJ, Smith K, Atherton PJ, et al. A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study. F1000Res. 2017; 6:1235. DOI: 10.12688/f1000research.11894.2
25- Shadmanfard A, Nemati A, Naghizadeh Baghi A, Mazani M. The effect of pomegranate juice supplementationon oxidative stress in young healthy males. J Ardabil Univ Med Sci. 2013; 12 (5 Suppl.1): 77-86. [Persian] URL: http://jarums.arums.ac.ir/article-1-101-en.html
26- Urbaniak A, Basta P, Ast K, Wołoszyn A, Kuriańska–Wołoszyn J, Latour E,et al. The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr. 2018; 15(1): 1-9. DOI: 10.1186/s12970-018-0241-z
27- Bayat-Chadegani, E., Fallahzadeh, H., Askari, G., Rahavi, R., Maghsoudi, Z., Nadjarzadeh, A. The Effect of Pomegranate Juice Supplementation on Muscle Damage, Oxidative Stress and Inflammation Induced by Exercise in Healthy Young Men. J Isfahan Med Sch. 2015; 32(320): 2464-72. [Persian] URL: http://jims.mui.ac.ir/article_14547.html?lang=fa
28- Atashak S, Azizbeigi K. Effects of concurrent exercise training on the oxidative stress biomarkers concentration in elderly men. Koomesh. 2017; 19 (1): 36-45. [Persian] URL: http://koomeshjournal.semums.ac.ir/article-1-3005-fa.html
29- Rahimifardin S, Siakuhian M, Nakhostin Roohi B, Farhadi H, Shahravan N, Hassanzadeh Z. Effect of pomegranate supplementation and aerobic training on total antioxidant capacity and lipid peroxidation in overweight men . J Birjand Univ Med Sci. 2014; 21 (3): 332-340. [Persian] URL: http://journal.bums.ac.ir/article-1-1631-fa.html
30- Yarmohammadi M, Mahjoub S. Assessment of six weeks moderate-intensity aerobic exercise with and without pomegranate extract consumption effects on plasma malondialdehyde level in adult women with type-2 diabetes. EBNESINA. 2017; 19 (3): 56-9. [Persian] URL: http://ebnesina.ajaums.ac.ir/article-1-513-en.html
2- Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014; 15 (4): 6184-223. DOI: 10.3390/ijms15046184
3- Fabricatore AN, Wadden TA. Psychological aspects of obesity. Clin Dermatol. 2004; 22 (4): 332-7. DOI: 10.1016/j.clindermatol.2004.01.006
4- Jones, G, L., Sutton, A. Quality of life in obese postmenopausal women. Menopause Int, 2008; 14 (1): 26–32. DOI: 10.1258/mi.2007.007034
5- Stelzer I, Zelzer S, Raggam RB, Prüller F, Truschnig-Wilders M, Meinitzer A, et al. Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation. Transl Res. 2012; 159 (2):118-24. DOI: 10.1016/j.trsl.2011.10.001
6- Jialal I, Kaur H, Devaraj S. Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J Clin Endocrinol Metab. 2014; 99 (1): 39-48. DOI: 10.1210/jc.2013-3092
7- Farhadi M, Matin Homaee H, farzanegi P. The effect of six months’ resistance training and ginger extract on lipid profiles, body composition and selected liver enzymes in obese menopausal women. J Neyshabur Univ Med Sci. 2020; 8 (2): 59-71. [Persian] URL: http://journal.nums.ac.ir/article-1-817-en.html
8- Sharifi A, Amani R, Hamidipur N. Prevalence of obesity and its related lifestyle pattern in male personnel of Ahvaz Jundishapour University of medical sciences. Endocrin Metabol 2008; 10 (3): 235-9. [Persian] URL: http://ijem.sbmu.ac.ir/article-1-538-en.html
9- Trombold JR, Reinfeld AS, Casler JR, Coyle EF. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J Strength Cond Res. 2011 Jul 1; 25(7): 1782-8. DOI:10.1519/JSC.0b013e318220d992
10- Esmaelzadeh toloee, M., Afshar nezhad, T., Yazdani, F., Ahmadi, B. The Effect of 8 Weeks of Resistance Training on Ovary Morphology, Glycemic control and Body Composition on Women with Polycystic Ovary Syndrome. Medical Journal of Mashhad University of Medical Sciences. 2015; 58(7): 381-389. [Persian] DOI: 10.22038/mjms.2015.5609
11- Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev. 2008; 7(1): 34-42. DOI: 10.1016/j.arr.2007.04.004
12- Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008; 4(2): 89-96. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/
13- Kurkcu R. The effects of short-term exercise on the parameters of oxidant and antioxidant system in handball players. Afr J Pharm Pharmacol. 2010; 4(7): 448-52. DOI: 10.5897/AJPP.9000270
14- Tarverdizadeh B, Bedrous Oghoubian Salmasi M. The Effect of Interval Training on HSP70 and Some Inflammatory, Growth and Functional Markers among Women with Breast Cancer. Iran J Obstet Gynecol Infertil. 2016; 19(37): 16-24. [Persian] DOI: 10.22038/IJOGI.2016.8184
15- Akbarpour M, Fathollahi Shoorabeh F, Faraji F. Effects of eight weeks of resistance training and consumption of pomegranate on GLP-1, DPP-4 and glycemic statuses in women with type 2 diabetes: A randomized controlled trial. Nutr Food Sci Res. 2021; 8 (1): 5-10. URL: http://nfsr.sbmu.ac.ir/article-1-418-en.html
16- Esmaeilinezhad Z, Boldaji RB. The Effect of Pomegranate and Its Compounds on Breast Cancer. J Shahid Sadoughi Uni Med Sci. 2019; 27(8): 1814-25. [Persian] DOI: 10.18502/ssu.v27i8.2036
17- Mirazi N, Nosrati S, Hosseini A. Evaluation of pomegranate rind (Punica granatum) hydroethanolic extract on blood parameters in male mice treated by Irinotecan Hcl. Armaghan-e Danesh. 2015 May 15; 20(2): 114-26. [Persian] URL: http://armaghanj.yums.ac.ir/article-1-487-en.html
18- Zarban A, Malekaneh M, & Boghrati M. R. Antioxidant properties of pomegranate juice and its scavenging effect on free radicals. J Birjand Univ Med Sci. 2007; 14(3): 9-15. URL: http://journal.bums.ac.ir/article-1-149-en.html
19- Zarezadeh M, Saedisomeolia A, Hosseini B, Emami M R. The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial. Qom Univ Med Sci J. 2019; 13 (8): 14-25. DOI: 10.29252/qums.13.8.14
20- Akbarpour M, Fathollahi Shoorabeh F, Mardani M, Amini Majd F. Effects of Eight Weeks of Resistance Training and Consumption of Pomegranate on GLP-1, DPP-4 and Glycemic Statuses in Women with Type 2 Diabetes: A Randomized Controlled Trial. Nutr Food Sci Res. 2021; 8 (1): 5-10. URL: http://nfsr.sbmu.ac.ir/article-1-418-en.html
21- Hooshmand-Moghadam, B., Choobineh, S. Effect of Pomegranate Supplementation on Antioxidant Status in Young Women after Heavy Resistance Exercise. Journal of Animal Biology. 2017; 10(1): 101-12. [Persian] URL: http://ascij.damghaniau.ac.ir/article_538432.html?lang=en
22- Sori M, Kolivand M, Salari N, Bakhshi N. Investigating the relationship between regular exercise and menopausal symptoms in postmenopausal women. J Health. 2021; 12(1): 84-93. DOI: 10.52547/j.health.12.1.84
23- Farhadi H, Rahimi Fardin S, Baghaiee B. The effect of 8 week of pomegranate supplementation on inflammatory and muscular damage indices in over weight untrained men due todifferent intensity VO2max. Journal of Practical Studies of Biosciences in Sport. 2017; 5(9): 31-41. [Persian] DOI: 10.22077/JPSBS.2017.619
24- Cegielski J, Brook MS, Quinlan JI, Wilkinson DJ, Smith K, Atherton PJ, et al. A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study. F1000Res. 2017; 6:1235. DOI: 10.12688/f1000research.11894.2
25- Shadmanfard A, Nemati A, Naghizadeh Baghi A, Mazani M. The effect of pomegranate juice supplementationon oxidative stress in young healthy males. J Ardabil Univ Med Sci. 2013; 12 (5 Suppl.1): 77-86. [Persian] URL: http://jarums.arums.ac.ir/article-1-101-en.html
26- Urbaniak A, Basta P, Ast K, Wołoszyn A, Kuriańska–Wołoszyn J, Latour E,et al. The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr. 2018; 15(1): 1-9. DOI: 10.1186/s12970-018-0241-z
27- Bayat-Chadegani, E., Fallahzadeh, H., Askari, G., Rahavi, R., Maghsoudi, Z., Nadjarzadeh, A. The Effect of Pomegranate Juice Supplementation on Muscle Damage, Oxidative Stress and Inflammation Induced by Exercise in Healthy Young Men. J Isfahan Med Sch. 2015; 32(320): 2464-72. [Persian] URL: http://jims.mui.ac.ir/article_14547.html?lang=fa
28- Atashak S, Azizbeigi K. Effects of concurrent exercise training on the oxidative stress biomarkers concentration in elderly men. Koomesh. 2017; 19 (1): 36-45. [Persian] URL: http://koomeshjournal.semums.ac.ir/article-1-3005-fa.html
29- Rahimifardin S, Siakuhian M, Nakhostin Roohi B, Farhadi H, Shahravan N, Hassanzadeh Z. Effect of pomegranate supplementation and aerobic training on total antioxidant capacity and lipid peroxidation in overweight men . J Birjand Univ Med Sci. 2014; 21 (3): 332-340. [Persian] URL: http://journal.bums.ac.ir/article-1-1631-fa.html
30- Yarmohammadi M, Mahjoub S. Assessment of six weeks moderate-intensity aerobic exercise with and without pomegranate extract consumption effects on plasma malondialdehyde level in adult women with type-2 diabetes. EBNESINA. 2017; 19 (3): 56-9. [Persian] URL: http://ebnesina.ajaums.ac.ir/article-1-513-en.html
Type of Study: Original Article |
Subject:
Exercise Physiology
Received: 2022/03/14 | Accepted: 2022/05/18 | ePublished ahead of print: 2022/06/27 | ePublished: 2022/09/3
Received: 2022/03/14 | Accepted: 2022/05/18 | ePublished ahead of print: 2022/06/27 | ePublished: 2022/09/3
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