Volume 28, Issue 2 (July 2021)
J Birjand Univ Med Sci. 2021, 28(2): 179-184 |
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Research code: 455860
Ethics code: IR.BUMS.REC.1398.182
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Abasnia F, Fakharian T, Salmany F. Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand: Short Communication. Journals of Birjand University of Medical Sciences 2021; 28 (2) :179-184
URL: http://journal.bums.ac.ir/article-1-2901-en.html
URL: http://journal.bums.ac.ir/article-1-2901-en.html
1- Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
2- Internal medicine Departments, Birjand University of Medical Sciences, Birjand, Iran ,t.fakharian@gmail.com
3- Department of Epidemiology and Biostatistics, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran
2- Internal medicine Departments, Birjand University of Medical Sciences, Birjand, Iran ,
3- Department of Epidemiology and Biostatistics, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran
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ABSTRACT
Since helicobacter pylori is a prevalent infection in Iran, it is necessary to search for an effective, low-cost, and easy diet to eradicate it. This study compares the effect of levofloxacin-based regimen along with clarithromycin-based regimen on the treatment of helicobacter pylori (H. pylori). This quasi-experimental study was performed on 161 patients with H. pylori infection who referred to the gastrointestinal clinic of Valiasr Hospital in Birjand, Iran. The patients were randomly divided into two groups. The first group was treated with levofloxacin, pantoprazole, and amoxicillin, and the second group received amoxicillin, pantoprazole, clarithromycin, and bismuth sub citrate for 14 days. The urease breath test was performed four weeks after the end of the treatment to check the eradication of the condition. The eradication occurred in 67 (91.8%) and 55 (70.5%) patients treated with levofloxacin and clarithromycin, respectively. A p-value of 0.001 was considered statistically significant. Moreover, there was no statistically significant difference between two groups in terms of complications (P=0.3). The results showed that the levofloxacin-based regimen could be used as an alternative to four clarithromycin-based therapies due to its greater efficacy in eradication of H. pylori despite the lower number of drugs and similar side effects.
Since helicobacter pylori is a prevalent infection in Iran, it is necessary to search for an effective, low-cost, and easy diet to eradicate it. This study compares the effect of levofloxacin-based regimen along with clarithromycin-based regimen on the treatment of helicobacter pylori (H. pylori). This quasi-experimental study was performed on 161 patients with H. pylori infection who referred to the gastrointestinal clinic of Valiasr Hospital in Birjand, Iran. The patients were randomly divided into two groups. The first group was treated with levofloxacin, pantoprazole, and amoxicillin, and the second group received amoxicillin, pantoprazole, clarithromycin, and bismuth sub citrate for 14 days. The urease breath test was performed four weeks after the end of the treatment to check the eradication of the condition. The eradication occurred in 67 (91.8%) and 55 (70.5%) patients treated with levofloxacin and clarithromycin, respectively. A p-value of 0.001 was considered statistically significant. Moreover, there was no statistically significant difference between two groups in terms of complications (P=0.3). The results showed that the levofloxacin-based regimen could be used as an alternative to four clarithromycin-based therapies due to its greater efficacy in eradication of H. pylori despite the lower number of drugs and similar side effects.
منابع:
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2- Fakheri H, Bari Z, Aarabi M, Malekzadeh R. Helicobacter pylori eradication in West Asia: a review. World J Gastroenterol. 2014; 20(30): 10355–10367. DOI: 10.3748/wjg.v20.i30.10355
3- Yu L, Luo L, Long X, Liang X, Ji Y, Graham DY, et al. High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: A randomized trial. Helicobacter. 2019; 24(4): e12596. DOI: 10.1111/hel.12596
4- Mohammadi M, Doroud D, Mohajerani N, Massarrat S. Helicobacter pylori antibiotic resistance in Iran. World J Gastroenterol: WJG. 2005; 11(38): 6009-13. DOI: 10.3748/wjg.v11.i38.6009
5- Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2017; 112(2): 212-39. DOI: 10.1038/ajg.2016.563
6- Dib J, Jr., Alvarez B, Mendez L, Cruz ME. Efficacy of PPI, levofloxacin and amoxicillin in the eradication of Helicobacter pylori compared to conventional triple therapy at a Venezuelan hospital. Arab J Gastroenterol. 2013; 14(3): 123-5. DOI: 10.1016/j.ajg.2013.09.001
7- Jameson JL. Harrison's principles of internal medicine. 20th edition. New York: McGraw Hill Education, 2018.
8- Saad RJ, Schoenfeld P, Kim HM, Chey WD. Levofloxacin-Based Triple Therapy versus Bismuth-Based Quadruple Therapy for Persistent Helicobacter pylori Infection: A Meta-Analysis: CME.Am J Gastroenterol. 2006; 101(3): 488-96. DOI: 10.1111/j.1572-0241.2006.00637.x.
9- Nista EC, Candelli M, Cremonini F, Cazzato IA, Di Caro S, Gabrielli M, et al. Levofloxacin‐based triple therapy vs. quadruple therapy in second‐line Helicobacter pylori treatment: a randomized trial. Aliment Pharmacol Ther 2003; 18(6): 627-33. DOI: 10.1046/j.1365-2036.2003.01676.x
10- Bakhshi S, Ghazvini K, Beheshti A, Ahadi M, Sheykhi M. Review of antibiotic resistance of Helicobacter pylori in Iran and the world. medical journal of mashhad university of medical sciences. 2017; 60(4): 648-61. [Persian] DOI: 10.22038/mjms.2017.10191
Type of Study: Short Communication |
Subject:
Gastroenterology
Received: 2020/08/15 | Accepted: 2020/10/27 | ePublished ahead of print: 2020/11/8 | ePublished: 2021/06/20
Received: 2020/08/15 | Accepted: 2020/10/27 | ePublished ahead of print: 2020/11/8 | ePublished: 2021/06/20
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