Volume 26, Issue 1 (Spring 2019)                   J Birjand Univ Med Sci. 2019, 26(1): 13-20 | Back to browse issues page

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Sofiabadi M, Soheili M M, Soleimani P. Effect of Passiflora extract on passive avoidance learning and memory in male rats. J Birjand Univ Med Sci.. 2019; 26 (1) :13-20
URL: http://journal.bums.ac.ir/article-1-2563-en.html
1- Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Student Research Committee, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin, Iran. , sohily20@gmail.com
3- Student Research Committee, Faculty of Nursing, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract:   (5343 Views)

Background and Aim: Studies of memory impairment and memory loss associated with age, has led to the introduction of new therapies, including uses of medical herbs to improve memory. The aim of this study was to evaluate the effect of oral administration of Passiflora extract on passive avoidance Learning and Memory in male rats.
Materials and Methods: In this experimental study, 40 male rats were divided into; control group, sham (solvent) and 3 Passiflora extract treated groups (50, 100 and 200 mg/ kg). The gavage was continued from the 1 week before the shock to 2 weeks afterwards. Learning and memory were evaluated using the passive avoidance test (shuttle box). Data were analyzed by SPSS software, using ANOVA and Tukey-post hoc test.
Results: Oral administration of  Passiflora extract in all 3 doses increased the latency of the entrance to the dark room, which was significant in the one week after the shock compared to control group(P <0.05).
Conclusion: The Passiflora extract consumption improved dose dependently betterment learning and memory. So it seems that, it’s using be effective for cognitive impairment prevention and treatment.

Keywords: Passiflora, Learning, Memory, Rat
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Type of Study: Original Article | Subject: Traditional medicine and Complementary Medicine
Received: 2018/09/23 | Accepted: 2018/12/4 | ePublished: 2019/03/17

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