Volume 21, Number 4 (January 2015)                   J Birjand Univ Med Sci. 2015, 21(4): 425-431 | Back to browse issues page


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Hosseini E. Effect of Aalcoholic Extract of Hop Flowers on Serum Level Pituitary-Thyroid Hormones in Adult Male Rats . J Birjand Univ Med Sci.. 2015; 21 (4) :425-431
URL: http://journal.bums.ac.ir/article-1-1551-en.html

Associate Professor, Department of Biology, Islamic Azad University, Shiraz branch, Shiraz, Iran , ebrahim.hossini@yahoo.com
Abstract:   (5040 Views)
Background and Aim: Hop with, scientific name of Humulus Lupulus, has got estrogenic, sedative, hypnotic, and antiseptic properties in the treatment of certain diseases. The present study aimed at assessing the effects of the herb on pituitary–thyroid hormones in adult male rats. Materials and Methods: This experimental study was conducted on 45 adult male Wistar rats. The rats were divided into 5 equal groups including control (no treatment), control (saline) and three experimental groups receiving doses of the hop flower extract 50,100, and 150mg/kg gavage for 10 days, respectively. At the end of the tenth day .,blood samples were derived from the rats’ hearts and their blood hormone concentrations of Thyrotropin (T3), Thyroxine (T4), and Thyrotropin (THS) were measured by means of gamma counter . The obtained data was analysed employing SPSS software (V: 18) using Anova and Tukey. Statistical tests at the significant level P≤0.05. Results: It was found that the experimental groups receiving doses of 150 and 100 mg/kg, their serum hormone levels of T3, T4 and TSH levels significantly reduced (P≥0.05). Conclusion: The results showed that the ethanol extract of hop flowers with a flavonoid phytoestrogens reduce T4, T3 and TSH hormones.
Full-Text [PDF 236 kb]   (1273 Downloads)    
Type of Study: Original Article | Subject: Physiology
Received: 2013/12/31 | Accepted: 2014/07/20 | Published: 2015/02/4

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