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Background and Aim: Some physiological and psychological variables have a circadian rhythm or cyclical changes and many physiological responses to exercise, e.g. cardiovascular diseases (CVD) are somehow affected by their time of the day .Thus, .the present study aimed at finding out the effect of the time of the day on plasma levels of C-reactive protein (CRP) and lipid profile after one session of exhaustive exercise in apparently healthy young women in Birjand in 2011. Materials and Methods: The present study was a quasi-experimental pre/post one. Forty-four active women (mean. age 21.59±1.24 yrs. mean BMI 21.11±2.74kg/m2) were divided into 2 experimental and 2 control groups. The experimental groups performed the Bruce treadmill maximal protocol after 12 hours fasting at 8 a.m. and at 6 p.m. Then, blood samples of all participants were derived from the antecubital vein of each before and immediately after the test. Finally, the obtained data was analyzed using the two-way ANOVA test. Results: A significant decrease in CRP levels was observed in the evening post-exercise period compared with the pre-test (p=0.008), while CRP levels after the morning exercise had no significant change compared with the pre-test. Plasma triglyceride (TG) level significantly increased after both of morning and evening exercises (p=0.002). But, no significant changes in TG, HDL and LDL cholesterol levels were found after morning and evening exercises. Conclusion: Taking CRP response into account, it seems that high intensity exercise in the evening is better and safer than the same exercise in the morning.

Keywords: Morning exercise, Evening exercise, Bruce treadmill test, C-reactive protein, Lipid profile

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