Volume 20, Number 2 (July 2013)                   J Birjand Univ Med Sci. 2013, 20(2): 144-152 | Back to browse issues page


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Ayoubi A, Omidi A, Valizade R, Mousaei A. Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats . J Birjand Univ Med Sci.. 2013; 20 (2) :144-152
URL: http://journal.bums.ac.ir/article-1-1335-en.html

1- MA in Animal Physiology, Department of Animal Science, Ferdowsi University of Mashhad
2- Associate Professor, Department of Animal Health Management, Faculty of Veterinary Medicine, Shiraz , aomidi@shirazu.ac.ir
3- Professor, Department of Animal Science, Ferdowsi University of Mashhad
4- PhD student of Animal Nutrition, Department of Animal Science, Ferdowsi University of Mashhad
Abstract:   (20112 Views)
Background and Aim: Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose, total cholesterol, LDL, HDL, VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats. Materials and Methods: In this experimental research, forty rats were randomly divided into five equal groups. Trials in the study included the control group, diabetics (50 mg/kg STZ), diabetics+extract of Aloe vera (300mg/kg), diabetics+Teucrium (300mg/kg), and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated. Results: Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0.05). It was found that concentration of total cholesterol, HDL, VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0.05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats. Conclusion: The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDL
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Type of Study: Original Article | Subject: Pharmacology
Received: 2013/01/15 | Accepted: 2013/07/23 | Published: 2016/03/10

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