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URL: http://journal.bums.ac.ir/article-1-1219-en.html
, Mahdi Honarkar Ramezani1 , Meysam Noorani Arani1 , Azhdar Heydari1 , Hamid Reza Banafshe * 2
2- Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran ,
Materials and Methods: Experiments were performed on six groups (n=8) of male Sprague-Dawley rats (230-280g). The groups consisted of the control group, induced chronic constriction of the sciatic nerve (CCI), 3 groups receiving ethosuximide with concentrations 100, 200, 300mg/kg, and one group which received normal saline. The cold-and mechano-allodynia and thermal hyperalgesia were measured prior to surgery (the day 0) and 3, 5, 7, 14 and 21 days postsurgery. Statistical analysis of repeated ANOVA was used to compare the results of behavioral tests by means of SPSS software (V: 16).
Results: It was found that the CCI group significantly produced mechanical and cold allodynia and a hypersensitivity to noxious stimulations. Ethosuximide significantly decreased cold and mechano-allodynia and thermal hyperalgesia.Conclusion: Results suggested that the CCI model significantly influences behavioral responses to both the thermal and mechanical stimulations. Besides, systemic administration of ethosuximide significantly decreases behavioral responses of neuropathic pain induces through CCI. Thus, ethosuximide can be taken as a new potential therapeutic drug used against neuropathic pain.
Received: 2012/09/3 | Accepted: 2013/05/15 | ePublished: 2016/03/10
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