Volume 23, Issue 1 (April 2016)                   J Birjand Univ Med Sci 2016, 23(1): 11-20 | Back to browse issues page

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Hoseini R, Babaei P, Damirchi A. The Effect of Different Doses of Vitamin D Supplementation on Insulin Resistance in ovariectomized rats. J Birjand Univ Med Sci. 2016; 23 (1) :11-20
URL: http://journal.bums.ac.ir/article-1-1870-en.html
1- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Razi University of Kermanshah, Kermanshah, Iran , Rastegar.hoseini@gmail.com
2- Department of Physiology, Guilan University of Medical Sciences, Rasht, Iran
3- Department of Sport Physiology, Faculty of physical education and sport sciences, University of Guilan, Rasht, Iran
Abstract:   (16253 Views)

Background and Aim: Type 2 diabetes mellitus (T2DM) and vitamin D deficiency are both too common during menopause. Since the effect of different doses of vitamin D supplements on blood sugar, insulin concentration  and insulin resistance are unknown, the present study aimed at investigating the effects of different doses of the vitamin D supplements on visceral fat, blood sugar, insulin concentration,  and insulin resistance in ovariectomized rats.

Materials and Methods: In this randomized experimental study, 32 female Wistar rats were divided into 4 equal groups  as follows: three groups . that received vitamin D supplements (high, moderate, and low dose) and one control group. After 8 weeks of different doses of vitamin D supplementation plasma concentration of glucose, insulin and HOMA-IR were measured  in the three groups. The obtained data  was statistically analyzed by means of dependent t-test and ANOVA . at the significance level of P<0.05.

Results: After a period of eight-week  intervention, body weight, BMI, waist circumference, visceral fat, insulin, blood glucose and HOMA-IR at high, moderate, and low doses of vitamin D supplementation were significantly lower than those in the control group (P<0.05). High dose of vitamin D compared with moderate and low doses significantly caused reduction in insulin, blood glucose, and HOMA-IR (P<0.001 for all three variables).

Conclusion: The findings of the current study showed that a high dose of vitamin D causes significant improvements in FPG, insulin, and insulin resistance  evaluated by HOMA-IR. It was also found that adding vitamin D supplements can improve glucose control in menopause model of rats.

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Type of Study: Original Article | Subject: Nutrition
Received: 2015/05/11 | Accepted: 2016/04/17 | ePublished: 2016/05/10

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