Volume 30, Issue 1 (June 2023)
J Birjand Univ Med Sci. 2023, 30(1): 56-66 |
Back to browse issues page
Research code: 950461063
Ethics code: IR.IAU.M.REC.1401.029
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Shojaeyan M, Abedi B, Hosseini S A. Effect of periodic of resistance training on lipid peroxidation and Tumor necrosis factor-alpha in the heart tissue of male rats exposed to stanazol. J Birjand Univ Med Sci. 2023; 30 (1) :56-66
URL: http://journal.bums.ac.ir/article-1-3246-en.html
URL: http://journal.bums.ac.ir/article-1-3246-en.html
1- PhD Student in Sports Physiology, Department of Physical Education and Sports Sciences, Islamic Azad University, Mahallat, Iran
2- Department of Physical Education and Sports Sciences, Mahallat Branch, Islamic Azad University, Mahallat, Iran , abedi@iaumahallat.ac.ir
3- Department of Physical Education and Sports Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
2- Department of Physical Education and Sports Sciences, Mahallat Branch, Islamic Azad University, Mahallat, Iran , abedi@iaumahallat.ac.ir
3- Department of Physical Education and Sports Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Abstract: (406 Views)
Background and Aims: Nowadays, the use of energizing substances has become a complex complicated problem in sports and causes damage to various tissues., on the other hand However, sports activity has a significant impact on controlling and improving oxidative stress factors and inflammatory indicators. Therefore, this study aimed to investigate the effect of eight- weeks of resistance training on lipid peroxidation (malondialdehyde [MDA]MDA) and tumor necrosis factor-alpha (TNF-α) in the heart tissue of rats exposed to stanazol.
Materials and Methods: In this experimental study, 24 male rats with a weight range of 150-200 g and a mean age of 8 weeks were selected and randomly divided into 4 groups (n=6 each), namely 1) control (C), 2) sham (Sh), 3) consumption of stanazol (S), and 4) consumption of stanazol together with resistance training (S+RT). During eight weeks, both groups of 3 and 4 received 5 mg/kg stanazol intraperitoneally daily; however, group 4 performed resistance training three times a week with an intensity of 30%-100% of their body weight. A one-way variance analysis and Tukey's post hoc test were used to analyze the data (P<0.05).
Results: Stanazol had a significant effect on increasing MDA (P=0.001) and TNF-α (P=0.001) in heart tissue. However, resistance training led to a decrease in MDA (P=0.001) and TNF-α (P=0.001) in the heart tissue of rats exposed to stanazol.
Conclusion: It seems that the consumption of anabolic steroids, especially stanazol, increased stress and MDA and TNF-α in the heart, while resistance training can could improve the increased levels of oxidative stress and inflammatory factorsdecrease its findings.
*Corresponding Author: Bahram Abedi; Emails: abedi@iaumahallat.ac.ir
Materials and Methods: In this experimental study, 24 male rats with a weight range of 150-200 g and a mean age of 8 weeks were selected and randomly divided into 4 groups (n=6 each), namely 1) control (C), 2) sham (Sh), 3) consumption of stanazol (S), and 4) consumption of stanazol together with resistance training (S+RT). During eight weeks, both groups of 3 and 4 received 5 mg/kg stanazol intraperitoneally daily; however, group 4 performed resistance training three times a week with an intensity of 30%-100% of their body weight. A one-way variance analysis and Tukey's post hoc test were used to analyze the data (P<0.05).
Results: Stanazol had a significant effect on increasing MDA (P=0.001) and TNF-α (P=0.001) in heart tissue. However, resistance training led to a decrease in MDA (P=0.001) and TNF-α (P=0.001) in the heart tissue of rats exposed to stanazol.
Conclusion: It seems that the consumption of anabolic steroids, especially stanazol, increased stress and MDA and TNF-α in the heart, while resistance training can could improve the increased levels of oxidative stress and inflammatory factorsdecrease its findings.
*Corresponding Author: Bahram Abedi; Emails: abedi@iaumahallat.ac.ir
You can also search for this author in: PubMed ResearchGate Scopus Google Scholar Google Scholar Profile
Type of Study: Original Article |
Subject:
Exercise Physiology
Received: 2023/02/10 | Accepted: 2023/06/21 | ePublished: 2023/06/5
Received: 2023/02/10 | Accepted: 2023/06/21 | ePublished: 2023/06/5
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Attribution-NoneCommercial CC BY-NC