Volume 29, Issue 3 (October 2022)
JBUMS 2022, 29(3): 229-240 |
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Research code: IR.KUMS.REC.1399.412.
Ethics code: IR.KUMS.REC.1399.412.
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Jafari M, Hosseinpour Delavar S, Safikhani H, Azizi M. The effect of the eight weeks of high intensity interval training and low intensity continuous training along with Citrus aurantium extract on tumor necrosis factor alpha and interleukin-6 in soleus muscle tissue of aged female rats. JBUMS 2022; 29 (3) :229-240
URL: http://journal.bums.ac.ir/article-1-3193-en.html
URL: http://journal.bums.ac.ir/article-1-3193-en.html
1- Department of Exercise Physiology, kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2- Department of Exercise Physiology, kermanshah Branch, Islamic Azad University, Kermanshah, Iran ,delavar2009@iauksh.ac.ir
3- Department of Physical education and sport sciences, Islamic Azad University, Abadan Branch, Abadan, Iran
2- Department of Exercise Physiology, kermanshah Branch, Islamic Azad University, Kermanshah, Iran ,
3- Department of Physical education and sport sciences, Islamic Azad University, Abadan Branch, Abadan, Iran
Abstract: (700 Views)
immune system in elderly people. This study aimed to investigate the effect of eight weeks of high-intensity interval training (HIIT) and low-intensity continuous training (LICT) along with Citrus aurantium (CA) extract on tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in soleus muscle tissue of aged female rats.
Materials and Methods: A total of 42 aged female rats were divided into (1) control (C), (2) LICT, (3) HIIT, (4) LICT+CA, (5) HIIT+CA, (6) CA, and (7) sham (normal-saline) groups. During eight weeks, HIIT was performed with an intensity of 85-90% of maximum speed and LICT with an intensity of 65% of maximum speed for five sessions per week, and 300 mg/kg/day of Citrus aurantium extract was daily intraperitoneally injected. The collected data were analyzed using one-way analysis of variance with Tukey's post hoc statistical tests (P≤ 0.05).
Results: TNF-α in LICT (P=0.001), HIIT+CA (P=0.004) and LICT+CA (P=0.007) groups were significantly lower than the C group. In the LICT group, TNF-α was significantly lower than the CA (P=0.001), HIIT (P=0.001), LICT+CA (P=0.02), and HIIT+CA (P=0.014) groups. It was also lower in the LICT+CA (P=0.007) and HIIT+CA (P=0.011) groups than the HIIT group. IL-6 levels in HIIT+CA group were significantly lower than the control group (P=0.02).
Conclusion: It seems that the training (continuous and interval) along with CA extract has favorable effect on TNF-α compared to HIIT; however, investigating the mechanism of intensity and type of training as well as different dosage of CA on IL-6 requires further studies.
Materials and Methods: A total of 42 aged female rats were divided into (1) control (C), (2) LICT, (3) HIIT, (4) LICT+CA, (5) HIIT+CA, (6) CA, and (7) sham (normal-saline) groups. During eight weeks, HIIT was performed with an intensity of 85-90% of maximum speed and LICT with an intensity of 65% of maximum speed for five sessions per week, and 300 mg/kg/day of Citrus aurantium extract was daily intraperitoneally injected. The collected data were analyzed using one-way analysis of variance with Tukey's post hoc statistical tests (P≤ 0.05).
Results: TNF-α in LICT (P=0.001), HIIT+CA (P=0.004) and LICT+CA (P=0.007) groups were significantly lower than the C group. In the LICT group, TNF-α was significantly lower than the CA (P=0.001), HIIT (P=0.001), LICT+CA (P=0.02), and HIIT+CA (P=0.014) groups. It was also lower in the LICT+CA (P=0.007) and HIIT+CA (P=0.011) groups than the HIIT group. IL-6 levels in HIIT+CA group were significantly lower than the control group (P=0.02).
Conclusion: It seems that the training (continuous and interval) along with CA extract has favorable effect on TNF-α compared to HIIT; however, investigating the mechanism of intensity and type of training as well as different dosage of CA on IL-6 requires further studies.
Type of Study: Original Article |
Subject:
Exercise Physiology
Received: 2022/07/21 | Accepted: 2022/12/17 | ePublished ahead of print: 2022/12/20 | ePublished: 2022/12/6
Received: 2022/07/21 | Accepted: 2022/12/17 | ePublished ahead of print: 2022/12/20 | ePublished: 2022/12/6
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