Background and Aim: Coagulopathy is a common phenomenon in brain trauma that affects the prognosis of the patients. This study aimed at evaluating the coagulation markers and its association with prognosis in patients with brain injury.

  Materials and Methods: This descriptive-analytical study was performed on 42 patients with head trauma with GCS ≤ 10 in Imam Reza Hospital of Birjand in 2006. Coagulation indices including PT, PTT, INR and platelet count were measured in all patients at the day 1 and 4 of admission. A score of zero was considered for the normal range of each marker and one for abnormal results. Total score was considered as the score of coagulopathy disorder. The changes in the consciousness level (GCS) and the outcome of the patients were recorded. Data were analyzed by means of SPSS version 11.5 and Fisher test at the significant level of P<0.05.

  Results: The most common observed coagulopathy in the day 1 and 4 was abnormal PT. Statistic analysis revealed significant association between the coagulopathy score in the fourth day and GCS changes in patients (P=0.04). Moreover, a significant association was observed between the coagulopathy score changes and the mortality of the patients (P=0.03).

  Conclusion: This study showed that the brain injury significantly affects the coagulation state and prognosis. Early detection of these changes may affect the outcome of the patients.