Showing 6 results for Type 2 Diabetes
Susan Behdani, Reza Dastjerdi, Gholam Reza Sharifzadeh,
Volume 19, Issue 3 (12-2012)
Abstract
Background and Aim: Diabetes mellitus is a prevalent chronic disease in the world, which threatens mental health. Various factors, including improvement of religious faith and increasing self-care efficacy, are effective in the treatment and control of the complications of the disease. The present study aimed at studying of the role of trust in God and self– efficacy in the mental health of type П diabetics. Materials and Methods: The present descriptive– analytical and correlational study was done on 204 type П diabetics selected through systematic randomized method. The patients' trust in God, self– efficacy, and mental health were assessed by means of "trust in God" questionnaires DMSES and GHQ-28. The obtained data was analysed by means of SPSS software (version 13), Pearson's correlation coefficient, t-test, and multiple regression analysis at the significant level α=0.05. Results: It was found that there was no significant difference between the two genders regarding trust in God, self-efficacy, and mental health at the level P<0.05. Besides, according to Pearson's coefficient correlation the relationship between trust in God and self-efficacy (P<0.001, r=0.45), between mental health and self-efficacy (P<0.001, r=0.44) was significant. Regression analysis revealed that trust in God and self-Efficacy justifies 35% of mental health variance in diabetics and are powerful prognosticators of the illness. Conclusion: Regarding the increase in the prevalence of diabetes mellitus, the disease is one of the notorious health problems in the world. Thus, intervention aimed at increasing religious faith and self-efficacy in order to do self-care activities will be useful in decreasing diabetic complications.
Masoome Boomi Ghochani Atigh, Arash Ghorbani, Asghar Zarban, Majid Shayesteh, Mohammad Malekaneh, Reyhane Hoshyar,
Volume 24, Issue 0 (10-2017)
Abstract
Background and Aim: Oxidative stress and atherogenic dyslipidemia are the main complications in type 2 diabetics. The present study aimed at comparing between serum 8-hydroxydeoxyguanosine (8-OHdG) and atherogenic index plasma (ARP) levels in type 2 diabetics and normal people.
Materials and Methods: In this study the relevant data of 50 type 2 diabetics ,who had referred to Emam Reza educational hospital and serum samples of random 50 healthy subjects, aged 27-70 yrs, was collected. The levels of 8-OHdG, AIP, and MDA in type II diabetics were measured by means of ELISA and TBARS, respectively. Their lipid profiles and plasma autherogenic indices were assessed through an autoanalyser.
Results: The case and control groups were homogenized regarding some demographic components such as age and gender .It was found that serum levels of 8OHdG,MDA, and AIP were significantly higher in the patients compared to the healthy controls ,aged 27-70 yrs (P<0.05, r=0.31). But, no significant relationship was found between 8OHdG and MDA (P=0.91, r=0.02).
The high rate of lipid peroxidation and DNA oxidation in type II diabetics can reveal outstanding oxidative stress predisposing them to CVDs complications
Conclusion: The lipid peroxidation and DNA oxidation in diabetic patients were indicated high oxidative stress in these patients, which can cause post complications such as cardiovascular disease.
Effat Dastigerdi, Shahla Khosravan, Gholamreza Sharifzadeh, Ahmad Nasiri-Fourg, Mansoor Soltani,
Volume 24, Issue 3 (11-2017)
Abstract
Background and Aim: Family behaviors are of great importance in the case of chronic diseases that require constant self-management. Chronic diseases management often involves changes in daily procedures that occur in family settings. This study aimed to determine the effect of education provided to family caregivers on supportive and obstructive behaviors of the family of individuals with type 2 diabetes.
Materials and Methods: In this randomized controlled clinical trial) IRCT2017053017756N15(, 60 family caregivers of type 2 diabetes patients were selected based on inclusion criteria and via convenience sampling method. They were allocated to intervention and control groups through simple randomization. For the intervention group, seven educational sessions were conducted along with telephone follow-up based on nursing diagnosis. The diabetes-specific Family Support Scale by Schafer et al. was completed by the patients before and two months after intervention. Data were analyzed in SPSS software) version 18(using T-test, Chi-square, and Wilcoxon tests.
Results: There was no significant difference between the two groups before the training. However, after the intervention, all the items of supportive behavior enhanced significantly in the intervention group compared with the control group (p <0.005). Moreover, the mean score of obstructive behavior was significantly lower in the intervention than in the control group (p <0.001).
Conclusion: Using the supportive and obstructive behavior training protocol of family caregivers, as an effective nursing intervention, promoted supportive behavior and reduced the obstructive behavior of family caregivers. Therefore, the implementation of this program can be recommended.
Ali Rajabi, Marefat Siahkouhian, Ali Akbarnejad, Morteza Yari,
Volume 24, Issue 4 (12-2017)
Abstract
Bachground: Type 2 diabetes is an important public health problem that involves many people. Exercise and physical activity play an important role in preventing and controlling it. Therefore, this study aimed to compare the effects of two different frequencies of aerobic exercise with the same volume and detraining period on the levels of irisin hormone, lipid profiles, and insulin resistance index in obese women with type 2 diabetes.
Materials and Methods: In this quasi-experimental study, 36 obese women with type 2 diabetes were randomly allocated into three groups (n = 12 per group). Group 1 and group 2 performed 8 weeks of intensity aerobic exercise (Group 1=3 times and Group 2=6 times a week, with the same volume) with 60-75 percent of maximum heart rate. Samples were taken before intervention, 48 hours after the first training session, and two weeks after the last training session.
Results: After 8 weeks of intervention, the intergroup results showed that weight, body fat, and body mass index were significantly reduced only in group 1, whereas in both groups, the insulin resistance index reduced and irisin levels increased significantly (P<0.05). One-way ANOVA with LSD post-hoc test indicated a significant difference between the study groups in terms of weight (P=0.036), fat percentage (P=0.001), BMI (P=0.008), insulin resistance (P=0.001), and irisin (P=0.0001) in the post-test phase.
Conclusion: Given the results of this study, the longer duration exercise protocol was of a more significant impact on the control of factors involved in type 2 diabetes than the exercise protocol with more frequent, short-term training sessions. Therefore, it can be concluded that the duration of an exercise program is an effective factor in the prevention and control of type 2 diabetes, which should be considered in the design and planning of exercise.
Masumeh Hemmati Maslakpak, Shahin Alipor, Nader Aghakhani, Hamidreza Khalkhali,
Volume 27, Issue 2 (6-2020)
Abstract
Background and Aim: The family can play an important role in adapting patients with diabetes to lifestyle changes, so that the family, as the most essential pillar of society, is responsible for the proper care of the patient with diabetes; Therefore, the present study was conducted to determine the effect of family-centered care on the adherence to treatment of patients with type 2 diabetes.
Materials and Methods: In this quasi-experimental study, 80 patients with type 2 diabetes and one member of their family were selected by convenience sampling method and randomly assigned to two of intervention and control groups. Adherence to treatment was assessed using a researcher-made questionnaire and laboratory values before and 3 months after the intervention. Data were analyzed using the Kolmogorov-Smirnov, Independent t-test, paired t-test, and Chi-square test.
Results: After the implementation of the family-centered care program, increased mean scores for patient adherence to treatment in the intervention group compared to the control group, this increase was statistically significant (p=0.0001). The results showed a decrease in the mean score of fasting blood glucose, random blood glucose and glycosylated hemoglobin in the intervention group compared to the control group. This decrease was statistically significant (P=0.0001).
Conclusion: Family-centered care can increase adherence to treatment, and decrease fasting blood glucose, random blood glucose and hemoglobin glycosylated levels. Therefore, it is recommended that family pay more attention to diabetic members.
Yaser Mohammadi, Azam Rezaei Farimani,
Volume 28, Issue 3 (9-2021)
Abstract
Background and Aims: SNARE proteins are composed of a combination of SNAP-23, Stx-4, and VAMP-2 isoforms that are significantly expressed in skeletal muscle. These proteins control the transport of GLUT4 to the cell membranes. The modifications in the expression of SNARE proteins can cause Type 2 diabetes. The present study aimed to assess the effect of metformin on the expression of these proteins in rats.
Materials and Methods: For the purpose of the study, 40 male Wistar rats were randomly selected. Streptozotocin and Nicotinamide were used for the induction of type 2 diabetes. The animals were assigned to five groups (n=8), including healthy and diabetic groups as control, as well as three experimental groups which were treated with different doses of metformin (100, 150, and 200 mg/kg body weight) for 30 days. The quantitative reverse transcription PCR (RT-qPCR) method was applied to evaluate the expression of SNARE complex proteins..
Results: Based on the results, metformin (100, 150, and 200 mg/kg body weight) decreased serum glucose levels and increased serum insulin levels. This difference in dose of 200 mg/kg body weight was statistically significant (P<0.05). Moreover, all three doses of metformin increased the expression of SNAP- 23, syntaxin-4, and VAMP-2 proteins in skeletal muscle tissue. Metformin at a dose of 200 mg/kg body weight demonstrated the most significant effects (P<0.05).
Conclusion: As evidenced by the results of the current study, another anti-diabetic mechanism of metformin is to increase the expression of SNARE proteins, which effectively improves insulin resistance and lowers blood glucose.
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