Search published articles


Showing 2 results for Tolerance
The effects of cardiac rehabilitation on physical tolerance in patients after coronary artery bypass graft
B Eftekhar Sadat, M Toofan Tabrizi, Sk Shakouri, S Aalavi Milani, L Kazemi,
Volume 16, Issue 4 (12-2009)
Abstract

  Background and Aim: Coronary artery disease is the most important cause of mortality in most countries including Iran which leads to significant disability, decrease in the quality of life, and death. According to previous studies, cardiac rehabilitation causes a significant decrease in mortality and has an important role in secondary prevention. The aim of this research was to determine the effects of cardiac rehabilitation on patients’ physical tolerance after coronary artery bypass graft (CABG).

  Materials and Methods: This research was a pre- and post-clinical trial in which 50 patients participated in a cardiac rehabilitation program for 2 months, 6 to 8 weeks following CABG surgery. The following variables had been studied before and after cardiac rehabilitation program: Maximum achieved heart rate and metabolic equivalent index which implies the functional capacity of every patient was investigated. The obtained data was analysed at the significant level of P<0.05 using SPSS (version 13) and relevant statistical tests.

  Results: Out of 50 patients: 72% were male and 28% female. Achieved maximum heart rate in 60% of the patients had increased after cardiac rehabilitation and metabolic equivalents of 88% of them had increased after rehabilitation. Besides, there was an increase in exercise tendency in 28% of the cases.

  Conclusion: Cardiac rehabilitation has important effects on functional capacity in patients after CABG.


Evaluation of the effect of Ferula gummosa essential oil on morphine tolerance and dependence in male mice
Gholrokh Farokhmehr, Ghader Najafi, Saeid Abbasi Maleki,
Volume 29, Issue 4 (12-2022)
Abstract
Background and Aims: The opioid system plays a key role in opioid tolerance and dependence. Furthermore, studies have shown that the opioid system plays a role in the analgesic effects of Ferula gummosa extract. Therefore, the present study aimed to investigate the effect of Ferula gummosa essential oil (FGEO) on morphine tolerance and dependence in mice.
Materials and Methods: In this experimental study, 60 albino mice were divided into 10 groups of 6 as follows: carrier (10 ml/kg), diazepam (5 mg/kg), and FGEO (40, 20, and 10 mg/kg). To induce morphine tolerance or dependence, it was administrated 3 times for 3 days. In the tolerance phase, drugs were injected intraperitoneally for 30 minutes before morphine administration. In the dependence phase, the drugs were used only on the 4th day (test day). The withdrawal signs were recorded for 30-min. The data were analyzed in SPSS software (version 20) through ANOVA and Kruskal-Wallis statistical tests, followed by Tukey's and Ben Feroni's post hoc tests..
Results: In total, 20 and 40 mg/kg doses of FGEO in the tolerance phase and only the high dose of the essential oil (40 mg/kg) decreased the number of jumps in the dependence phase. Other behaviors (e.g., diarrhea, stomach cramps, standing on two feet, climbing, wet dog shakes, self-treatment, and teeth chattering) decreased by FGEO in both phases.
Conclusion: FGEO decreased morphine tolerance and dependence and possibly was useful for the treatment of opioid dependence after complimentary trials.

Page 1 from 1     

© 2025 CC BY-NC 4.0 | Journal of Translational Medical Research

Designed & Developed by : Yektaweb