Showing 8 results for Heart Disease
M. Hashemzehi, M. Esmaeili Motlagh,
Volume 13, Issue 2 (7-2006)
Abstract
Background and Aim: According to previous studies, surgical closure of atrial septal defects (ASDs) was considered as the standard treatment. Two surgical methods, the conventional sternotomy (CSA: median sternotomy) and anterlateral thoracotomy were used. This study was carried out to compare early results of the two techniques in ASD's closure.
Materials and Methods: In this descriptive-analytical study from March 1998 to March 2004, the records of 73 patients with ASDs referring to Shahid Madany Hospital - affiliated to Tabriz University of Medical Sciences- were studied. The obtained data were analysed through filling out questionnaires Fisher, and Mann-Whitney accurate tests were used for statistical analyses at the significant level of P≤0.05.
Results: Out of 73 patients, 38 cases had undergone thoracotomy (group I) and 35 of them had experienced sternotomy (group II). The difference between mean surgery time in group I (4.33 hours) and in group II (3.43 hours) was significant at P<0.001. Duration of hospitalization between the two groups (10.08 and 12.79 days, respectively)- P=0.01, was significant. There was no significant differences on mean cross-aortic clamping time (32.35 and 35.88 minutes, respectively - P=0.41), mean time of extracorporeal circulation (65.68 and 69.48 minutes, respectively, - P=0.27). Besides, there was no significant difference between the two groups regarding the amount of drainage.
Conclusion: Right anterolateral thoracotomy for ASD closure can be an appreopriate technique, in terms of lower hospitalization days, limited surgical scar and better cosmetic outcome.
A. Amrai, M. Azemati, M. Moghaddam,
Volume 13, Issue 4 (12-2006)
Abstract
Background and Aim: Today ischemic heart diseases are the first reason of death in most societies , and in studies done some testimonies have reported about the role of inflammations and chronic infections in the pathogenesis of coronary heart disease. The aim of this study was to find out if there were any association between Helicobacter- pylori infection and atherosclerosis.
Materials and Methods: In this case-control study, endoscopy, urease test, and serology on 164 individuals (82 with coronary heart disease and 82 healthy ones) were performed to test the existence of Helicobacter-pylori. Finally, the obtained data were statistically analysed at the significant level of P≤0.05 by applying SPSS software and t-test.
Results: It was found that among 82 individuals in the control group urease test of 82.5% and serology test of 65% were positive and among the case group (82 patients) 75% of urease test and 70% of serology test was positive. There was not a meaningful relationship between infection and coronary heart disease (P=0.21).
Conclusion: In these two groups, whose age and gender were partly matched, there was not a meaningful statistical difference with regard to Helicobacter-pylori infection. Thus, other factors (inflammatory and non-inflammatory) for coronary heart disease should be investigated.
Gh Mortazavi Moghaddam,
Volume 15, Issue 2 (6-2008)
Abstract
While pulmonary thromboembolism is common, thromboembolic pulmonary hypertension is very rare. The present case is a 35 year old woman with chronic thromboembolic pulmonary hypertension, who presented with severe dyspnea and leg edema, following an earlier thrombotic event of 10 years earlier, after her her second childbearing. She also had a history of the first childbearing complicated with congenital heart disease and death of her infant by the age of 5 months. Despite conventional treatments for pulmonary thromboembolism including anticoagulants, her condition developed to severe pulmonary hypertension. The investigations including spiral CT confirmed bilateral pulmonary artery thrombosis, positive antiphospholipid antibody and negative serologic tests for rheumatic disease. Besides, the patient showed no symptoms of systemic vasculitis. Therefore, it was diagnosed that the patient had primary antiphospholipid syndrome without underlying rheumatic disease. Thus, the patient was referred to a thoracic surgeon for endarterectomy because of severe pulmonary hypertension (105 mlHg). However, due to extensive bilateral thrombotic involvement of pulmonary artery, surgical treatment was refused. Treatment with prednisolone 60mg/d and warfarin with high dose was carried out. The clinical condition was improved and dyspnea, edema and general condition recovered. The probable role of this syndrome in the development of chronic thromboembolic pulmonary hypertension, neonatal congenital heart disease, and also therapeutic strategies will be discussed in this report.
K Ghatreh Samani, F Roghani, E Farrokhi,
Volume 16, Issue 3 (10-2009)
Abstract
Background and Aim: Cardiovascular diseases (CVD), especially coronary heart diseases (CHD) are major causes of death in developed countries. Studies have been shown that total plasma homocysteine (tHcy) has been associated with an increased risk of CHD, probably a causal type. A lower tHcy concentration will reduce the frequency of CHD. The aim of this study was to evaluate the correlation between tHcy and CHD and its relationship with other CVD risk factors such as oxidized low density lipoprotein (ox-LDL).
Materials and Methods: A total number of 260 patients with coronary angiography indication were included in this case control study. The study group consisted of 130 patients with at least one vessel stenosis greater than 50% and the control group consisted of 130 normal angiogram without stenosis. Total Hcy, cholesterol, triglyceride, high density lipoprotein (HDL) and its sub fractions, low density lipoprotein (LDL) and ox-LDL were measured in two groups. Data were analyzed by SPSS using relevant statistical tests at the significant level of P<0.05.
Results: The mean serum tHcy level in CVD patients (19.25±8.20 µmol/L) was significantly higher (P<0.001) than the control group (14.8±4.17 µmol/L). Moreover, among patients with CVD, a positive significant correlation between tHcy and ox-LDL level in plasma, was found (r=0.426, P<0.001). Despite reduced HDL2 concentration in patients with CVD than the control group no significant correlation between high tHcy and low HDL2 was achieved in this study.
Conclusion: Beside other known effects, homocysteine may also act as a risk factor for cardiovascular diseases by increasing plasma ox-LDL concentration.
N Saadati, A Fazlinejad, H Falsolieman, M Mosavi,
Volume 16, Issue 4 (12-2009)
Abstract
Background and Aim: Cardiovascular disorders are the most common cause of premature deaths in patients with rheumatoid arthritis (RA). This study dealt with echocardiographical findings in patients with rheumatoid arthritis.
Materials and Methods: Forty patients with established diagnosis of RA for more than five years, who lacked any known cardiovascular and brain symptoms, were enrolled in the study. After complete physical examination electrocardiogram, Chest X-ray, and echocardiography were performed .The obtained data was analysed using SPSS software and appropriate statistical tests..
Results: Mean age of the subjects was 46/2±15/48 and 90% of them were females. The most common valvular disorders were tricuspid and mitral valve regurgitation (72.5% and 52%, respectively). In 70% of the patients diastolic function was normal and there was a significant relationship between systolic function and diastolic abnormality (P=0.047). Pulmonary hypertension was detected in 40% of the cases. Surveying diastolic indices and Doppler echocardiography revealed a significant relationship between initial diastolic wave rate starting from mitral valve annulus and the diastolic wave rate in the right upper pulmonary vein and a significant relationship between the systolic wave rate originated from mitral valve annulus and the systolic wave rate in the right upper pulmonary vein (P=0.001 and P=0.047, respectively). However, there was not a significant relationship between terminal diastolic wave rate starting from mitral valve annulus with terminal diastolic wave rate of mitral valve and an insignificant relationship of the systolic wave rate of the right upper pulmonary vein with initial diastolic wave rate of mitral valve (P=0.43 and P=0.84, respectively).
Conclusion: A wide and frequent variety of cardiovascular disorders, especially pulmonary hypertension, diastolic dysfunction, and tricuspid and mitral regurgitations in RA patients, require special attention.
S. Zand, K. Rezaie, H. Koohestani,
Volume 17, Issue 1 (3-2010)
Abstract
Background and Aim: In cases under heparin therapy, frequent blood samples must be taken for coagulation tests. Therefore, samples from saline lock can be a useful means to decrease the pain of taking frequent blood samples. The purpose of this study was to find the effect of this method on the validity of coagulation tests results.
Materials and Methods: In this case-control study a convenience sample of 63 cardiac patients participated. The blood sample taken from saline lock was accounted as the case and that taken from the opposite arm was the control sample. In order to obtain blood from saline lock, a tourniquet was applied proximal to the saline lock devices, after the first 0.5 ml of blood withdrawn was discarded and the next 5 ml blood sample was gathered for coagulation tests analyses. Simultaneously, a venipuncture 5 ml sample drawn from the opposite arm was taken as the control. Both blood samples were analyzed for coagulation tests. Results were analyzed by means of SPSS version 11.5 and paired T-test.
Results: Among the cases under study 53.96% were men. The most common reason of admission was unstable angina (46.03%). There were no significant differences in mean coagulation values in the blood samples obtained through venipunctures and those drawn from saline locks (P>0.05).
Conclusion: According to the results of this study, vein saline lock catheter sampling is a reliable and proper method for coagulation tests and can be a good alternative method in those patients who need repeated blood sampling.
Dr Alireza Agha Yousefi, Ahmad Alipour, Farhad Shaghaghi, Nasim Sharif,
Volume 19, Issue 2 (8-2012)
Abstract
Background and Aim: Coping ways with stress in coronary heart disease patients can lead to significant changes in the levels of biomarkers IL- 1 β and cortisol. Thus, the aim of the present study was to examine the relationship between coping ways with stress and level of IL- 1 β and cortisol in coronary heart disease patients.
Materials and Methods: The statistical population covered all patients with CHD who referred to Tehran Shahid Rajaie Heart Hospital. 44 patients with CHD admitted to different wards of the hospital were selected as eligible cases.In the present, Lazarus and Folkman questionnaires and Human IL- 1 β kits manufactured by Austrian Bender Med System Manufacturing Co and cortisol kits ( made by IBL Manufacturing Co., Germany),employing ELISA method of measurement ,were used.
Results: It was found that there was a significant positive correlation between emotional focused coping ways with biomarkers IL - 1 β and cortisol .But, a significant negative correlation was observed between problem focused coping ways and biomarkers IL-1 β and cortisol .Moreover, between 8 ways of coping with stress only predictive positive re-evaluation had a significant relationship with IL-1 β and Cortisol.
Conclusion: An increase in the use of problem focused coping ways including positive re-evaluation way can reduce levels of IL- 1 β and cortisol.
Zahra Moghadambarati, Mehri Khatami, Mohammad Mehdi Heidari, Mehdi Hadadzadeh, Reihane Ghorbanian,
Volume 31, Issue 1 (6-2024)
Abstract
Background and Aims: Tetralogy of Fallot (TOF) is one of infants' most common types of complex congenital heart defects (CHD). Several molecular mechanisms may play a role in its development, such as mutations in cardiac gene network components, cardiac gene regulatory pathways, dysfunction of cilia-expressing genes, and dysfunction of genes determining the left and right axis of the heart. The present study aimed to investigate the nucleotide changes of the CCDC103 gene and its relationship with CHD of the TOF type.
Materials and Methods: The present work was conducted for the first time in Iran as a case-control study on 85 children with TOF. The control group involved 56 healthy children without a family history of heart disorders. Touchdown polymerase chain reaction (PCR) and Sanger sequencing were used to evaluate point mutations in the CCDC103 gene. Moreover, bioinformatics databases were employed to predict the impact of nucleotide changes on protein structure and function.
Results: A total of five heterozygous single nucleotide changes were detected in this gene (three missense mutations: p.S115R, p.C191R, p.M201V, a synonymous change without amino acid change, and a change in the 3'-UTR region). In addition, bioinformatics results predicted that p.C191R mutation is pathogenic and harmful.
Conclusion: The results indicated that in addition to the genes known in the pathogenesis of TOF, changes in the CCDC103 gene in the ciliary signaling pathway can play a role in causing heart defects.
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