Alireza Ayoubi, Arash Omidi, Reza Valizade, Amir Mousaei,
Volume 20, Issue 2 (9-2013)
Abstract
Background and Aim: Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose, total cholesterol, LDL, HDL, VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats. Materials and Methods: In this experimental research, forty rats were randomly divided into five equal groups. Trials in the study included the control group, diabetics (50 mg/kg STZ), diabetics+extract of Aloe vera (300mg/kg), diabetics+Teucrium (300mg/kg), and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated. Results: Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0.05). It was found that concentration of total cholesterol, HDL, VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0.05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats. Conclusion: The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDL
Sedigheh Tanomand, Seyed Ebrahim Hosseini, Mohamad Amin Edalatmanesh,
Volume 25, Issue 3 (10-2018)
Abstract
Background and Aim: Aloe Vera gel, with strong antioxidant properties, is used in the treatment of many renal disorders. This study aimed to evaluate the effect of Aloe Vera gel (JA) on urea, uric acid and creatinine levels of serum, and tissue structure of kidneys of rats diagnosed with MS through Ethidium Bromide (EB).
Materials and Methods: This experimental study was performed on 48 female rats, which were divided into 6 groups of 8 samples, including control, sham (intraventricular treatment with saline), experimental treated with 14 μl of EB solution to the lateral ventricles with normal saline as a Gavage and receivers of 300, 600 and 1200 mg/ kg alcoholic extracts )JA(, as gavage with EB intraventricular meditation. In this study, prescriptions were taken for 35 days. In the end, after blood sampling from animal’s heart, some amount of urea, uric acid, and creatinine are extracted, and with providing different cross- sections, the tissue structure of their kidneys was studied based on histologic measurements. Finally, the data were analyzed using SPSS software (Version 20) using ANOVA and Duncan tests at the level of P <0.05.
Results: The results showed that EB increased serum urea, uric acid, and creatinine levels, decreased the diameter of the medulla, glomerulus, renal corpuscle sections, and increased the diameter of the near and further curved tubes at the level of P≤0.05. Furthermore, the treatment with high-dose JA significantly reduced the serum urea, uric acid and creatinine levels, increased the diameter of medulla sections, glomerulus, renal corpuscle, and reduced the near and further curved tubes alone in comparison with the EB group at P≤0.05.
Conclusion: Aloe Vera gel, in dose-dependent forms, can reduce urea, uric acid, creatinine, and tissue modification of kidneys in animals with MS.
Nima Rezaalizadeh, Anahita Arian, Kobra Naseri, Fatemeh Salmani, Ahmad Nasiri Furg,
Volume 29, Issue 1 (4-2022)
Abstract
Background and Aims: Dry skin is one of the most common skin complications associated with chronic renal failure in hemodialysis patients. Aloe vera gel and Violet oil can be effective in improving the symptoms of dryness through special mechanisms. Therefore, this study aimed to compare the topical effect of Aloe vera and Violet with hydroxyzine on dry skin of hemodialysis patients.
Materials and Methods: In this randomized crossover interventional trial, 36 people were selected according to the inclusion criteria and available sampling method. Following that, they were divided into three groups (12 cases per group) of A, B, and C by simple random sampling. The study consisted of three two-week intervention periods and two wash-out periods for one week. By performing a random allocation, all three groups received one of the interventions, including Aloe vera gel, Violet oil, or hydroxyzine tablets in each period. Data were collected using the VAS tool before and after the interventions by the co-researcher. The obtained data were then analyzed in SPSS software (version 16). Furthermore, SAS software (version 9.2) was also used to analyze crossover effects including period and carry-over effects. A P-value less than 0.05 was considered statistically significant.
Results: The results showed that in the first and third periods, in all three treatments, the mean score of dryness intensity had a statistically significant decrease before and after the intervention (P<0.05); however, this reduction in the second period was not significant in none of the treatments (P>0.05). In addition, the effect of all three treatments showed no statistical significance on the severity of dryness in patients after the intervention (P>0.05).
Conclusion: All three treatments can improve the symptoms of skin dryness as equipotent in hemodialysis patients. However, further research is needed to confirm the results of this study.
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