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Research code: --
Ethics code: IR.IAU.KHUISF.REC.1402.134
1- Department of Internal Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
2- Department of Internal Medicine, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran ,r.sareh2012@gmail.com
3- School of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
2- Department of Internal Medicine, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran ,
3- School of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
Abstract: (271 Views)
| Background and Aims: Some conditions, such as diabetes, may affect the prognosis of patients with breast cancer; therefore, this study aimed to determine the five-year survival rate of patients with breast cancer and its relationship with type 2 diabetes. Materials and Methods: This retrospective cohort study aimed to investigate the five-year survival rate of breast cancer patients. Breast cancer patients were divided into two groups: diabetic and non-diabetic, based on their type 2 diabetes status. Information on five-year survival status and associated factors, including age, body mass index (BMI), presence of metastasis, number of involved lymph nodes, tumor size, and immunohistochemical markers, was extracted from medical records. Subsequently, the two groups' survival rate and the influence of these factors were compared. Results: Of the 699 patients studied, 145 (20.7%) cases had diabetes. Among the examined factors, only age and body mass index (BMI) showed a significant difference between diabetic and non-diabetic patients. No significant association was observed between the distribution of hormone receptors in diabetic and non-diabetic breast cancer patients. Ultimately, this study demonstrated that type 2 diabetes was not significantly associated with the five-year survival of breast cancer patients. However, diabetic breast cancer patients were older and had a higher BMI than non-diabetic patients. Moreover, with increasing age and BMI, the risk of mortality increases. Conclusion: The findings of this study indicate that type 2 diabetes is not associated with the five-year overall survival of patients with breast cancer. This result may assist health policymakers in improving the care of diabetic patients with breast cancer. |
Type of Study: Original Article |
Subject:
Oncology
Received: 2025/04/25 | Accepted: 2024/10/21 | ePublished ahead of print: 2025/10/29
Received: 2025/04/25 | Accepted: 2024/10/21 | ePublished ahead of print: 2025/10/29
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