Volume 22, Issue 1 (April 2015)                   Journal of Scientific Research in Medical Sciences. 2015, 22(1): 39-47 | Back to browse issues page

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Hassanpour fard M, Hassanzadeh Tahery M M, Hosseini M, Ahani A, Ravanbakhsh N, Rabiey N et al . Evaluation of Anti-obesity Effects of Aqueous and Ethanolic Extracts of Pomegranate Fruit Peel Using Anthropometrical Indices in Male Wistar Rats. Journals of Birjand University of Medical Sciences 2015; 22 (1) :39-47
URL: http://journal.bums.ac.ir/article-1-1742-en.html
Evaluation of Anti-obesity Effects of Aqueous and Ethanolic Extracts of Pomegranate Fruit Peel Using Anthropometrical Indices in Male Wistar Rats
Mohammad Hassanpour fard1 , Mohammad Mehdi Hassanzadeh Tahery * 2, Mehran Hosseini3 , Abulfazl Ahani4 , Naeem Ravanbakhsh4 , Navid Rabiey4 , Amirreza Ghoreyshi4
1- Member of Berberis and Jujube Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran;
2- Member of berberis and jujube Research Center, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran , mmhtahery@yahoo.com
3- Member of Center for Experimental Medicine, Birjand University of Medical Sciences, Birjand, Iran
4- Member of the Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Abstract:   (13502 Views)
Background and Aim: The pomegranate fruit peel has been suggested in traditional medicine as an anti-obesity compound. Therefore, the study was carried out to evaluate the effects of aqueous or ethanolic extracts of pomegranate fruit peel on obesity and lipid profile in rat. Materials and Methods: In this experimental study, 24 Wistar male rats randomly divided into 4 equal groups (2 experimentals and 2 controls). The experimental groups A and E treated with aqueous or ethanolic extract of pomegranate peel at dose of 400 mg/kg, respectively, for 35 days. The control groups N and X respectively received 5mg/kg of saline and Xenical during the study as same as the experimental groups. The rats' weight, body mass index (BMI) and waist circumference were determined before and after investigation. Also at the end of study plasma lipid profile were measured. All data were analyzed by Prism software (ver- 3) and using paired samples t-test and ANOVA. Results: Comparison of weight change before and after the intervention showed a significant reduction in the Group E and a significant increase in group N (p≤0.05). Waist circumference was significantly increased in the experimental group A and control group N (p≤0.05) and reduced in group X (p≤0.05).There was no significant difference in plasma lipid profile between the groups. Conclusion: The ethanolic extract of pomegranate fruit peel can be considered as an anti-obesity compound in further studies.
Keywords: Body Weight, Body Mass Index, Obesity, Lipoproteins, Pomegranate Fruit Peel, Rats
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Type of Study: Original Article | Subject: Physiology
Received: 2014/11/2 | Accepted: 2015/05/11 | ePublished: 2015/05/11
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