Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Comparison of lumbar specific stabilization exercises and general exercises in reducing pain and disability in patients with spondylolysis and spondylolisthesis
1
10
FA
Asghar
Akbari
Department of Physiotherapy, Faculty of Rehabilitation Sciences, Zahedan University of Medical Sciences, Zahedan, Iran
akbari_as@yahoo.com
Parvane
Jahanshahi Javaran
Zahedan University of Medical Sciences, Zahedan, Iran
parvaz0_10@yah00.com
Background and Aim: Submaximal training of lumbar stabilizing muscles decreases both pain and disability in patients with mechanical low back pain. However, these effects have rarely been studied where segmental stability has been compromised. The purpose of the present study was to compare lumbar muscle specific stabilization exercises with general exercises in the reduction of pain and disability in patients with spondylolysis and spondylolisthesis.
Materials and Methods: This randomized controlled trial study was performed in Zahedan in 2009. Twenty-four patients with spondylolysis and spondylolisthesis were randomly assigned to either a stabilization (n=12) or a general exercise group (n=12). Before and after intervention, the extent of pain was assessed through Visual Analogue Scale (VAS), lumbar lordosis using a flexible ruler, range of lumbar flexion applying Modified Schober test, and disability severity by means of Oswestry Disability Index (ODI). A 24 thirty minute session exercise program lasting for 12 weeks, twice each week, were performed by both groups. The obtained data was fed into SPSS software (V:17) using statistical tests culmograph smear novo, Levin, independent T ,and paired T and analysed at the significant level P<0.05.
Results: Mean pain decreased from 6.1±2.5 to 2.7±2.5 in the stabilization group (P<0.0001) and from 6.3±1.8 to 3.3±1.3 in the general group (P=0.003). Besides, mean disability decreased from 33.4±9.03 to 9.12±5.1 in the stabilization group and from 32.5±6.12 to 18.52±4.68 in the general group (P<0.0001). Pain reduction (P=0.012) and function improvement (P<0.0001) was significant in stabilization group compared with the general one.
Conclusion: The results showed that stabilization exercises are more effective than the general ones in decreasing pain and improving function.
Low back pain, Stabilization exercise, General exercise, Spondylolysis, Spondylolisthesis
http://journal.bums.ac.ir/article-1-1082-en.html
http://journal.bums.ac.ir/article-1-1082-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Comparison between the effects of applying massage and ice massage to SP6 (SPLEEN6) point on severity and length of primary dysmenorrhea
11
19
FA
Mahbobeh
Rakhshekhorshid
School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran
Mohsen
Foadoddini
Atherosclerosis and Coronary Artery Disease Research Center, Physiology Department, Birjand University of Medical Sciences, Birjand, Iran
Seyyed Alireza
Saadatjoo
faculty member, Nursing and Midwifery Research Center of the east of Iran, Birjand University of Medical Sciences, Birjand, Iran
s_saadatjoo@yahoo.com
Background and Aim: Dysmenorrhea is one of the most common symptoms among women of productive age that is associated with several side effects. The aim of this study was to investigate the effects of applying massage and ice massage to SP6 (SPLEEN6) point on severity and length of primary dysmenorrhea.
Materials and Methods: This single-blind controlled trial study was done on 79 girls living in Birjand University of Medical Sciences dormitories during two menstrual cycles. The tools used in this study were visual analogue pain scale (VAPS) and clock. Data analysis was done by means of SPSS software (V: 15) using statistical tests variance analysis and X2 together with non-parametric tests Wilcoxon, Kruskal-wallis, and Mann-whitney.
Results: The study showed that mean pain intensity significantly decreased in massage and ice massage groups after intervention and the difference was significant (P<0.001). Besides, mean change in pain intensity in the massage group (0.91±1.16) was more than ice massage group (0.59±0.57) the difference being statistically significant (P<0.05). Mean of pain duration decreased after intervention in massage and ice massage groups and this reduction was significant (P<0.001). However the mean change in pain duration in the massage and ice massage groups was not significantly different from each other.
Conclusion: It was found that applying acupressure to SP6 point with or without ice causes significant reduction of duration and severity of dysmenorrhea in the intervention group compared to the control group.
Massage, Ice massage, SP6 point, Primary dysmenorrhea
http://journal.bums.ac.ir/article-1-1305-en.html
http://journal.bums.ac.ir/article-1-1305-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Effect of acetyl L carnitine on oxidative stress markers in hippocampus of epileptic rat
20
28
FA
Mehrdad
Roghani
Neurophysiology Research Center, Shahed University, Tehran, Iran
mehjour@yahoo.com
Zahra
Kiasalari
Research Center neurophysiology, Shahed University, Tehran, Iran
Mohsen
Khalili
Center for Traditional Medicine clinical neurophysiology and Research Center, Shahed University, Tehran, Iran
Farzane
Pesaran
Shahed University, Tehran, Iran
Background and Aim: Epilepsy is a rather common neurological disorder. Oxidative stress plays an important role in the pathogenesis of epilepsy. The present study was undertaken to evaluate the effect of acetyl L carnitine (ALC) on oxidative stress markers in hippocampus of epileptic rat.
Materials and Methods: In this experimental study, male rats were divided into sham, epileptic, valproic acid-treated epileptic ones at a dose of 200mg/kg, and 3 ALC-treated epileptic groups at doses of 50 and 100mg/kg for 3 days pre-surgery. Seizure activity was determined in 4 h periods and for measurement of oxidative stress markers, level of malondialdehyde (MDA), nitrite, and activity of superoxide dismutase (SOD) were determined in hippocampal homogenate. The obtained datawas fed into SPSS software (V:16) and for statistical analysis, one-way ANOVA and x2 tests were used.
Results: ALC treatment at doses of 50 and 100 mg/kg attenuated seizure intensity (P<0.05 and P<0.01, respectively), level of MDA significantly reduced (P<0.05) following ALC at a dose of 50 mg/kg, but nitrite level and SOD activity did not show significant changes.
Conclusion: ALC pretreatment has antiepileptic activity and at a dose of 50 mg/kg can reduce MDA level as an index of lipid peroxidation but it has no appropriate effect on nitrite level and SOD activity.
Acetyl L carnitine, Epilepsy, Kainic acid, Malondialdehyde, Nitrite and nitrate, Superoxide dismutase enzyme
http://journal.bums.ac.ir/article-1-1123-en.html
http://journal.bums.ac.ir/article-1-1123-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
An animal model for febrile seizure induction using hot water bath
29
36
FA
Mohamad Javad
Saeedi Borujeni
department of anatomical science and cell biology, Mashhad University of Medical Sciences, Mashhad ,Iran.
Ghasem
Sazegar
department of anatomical science and cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
sazegargh@mums.ac.ir
Seyyed Mojtaba
Mousavi
department of physiology, Mashhad University of Medical Sciences, Mashhad ,Iran
Javad
Hami
department of anatomical science, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Hossein
Haghir
department of anatomical science, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh
Alipour
department of anatomical sciences and cell biology, Mashhad University of Medical Sciences, Mashhad ,Iran
Background and Aim: Animal models offer an opportunity to induce febrile seizures in laboratories to assess the effects of neonatal fever and seizure on the central nervous system CNS). The present study aimed at introducing a method for febrile seizure induction in newborn rats.
Materials and Methods: In order to induce hyperthermia, a number of 22-day-old male rats were placed in a 45 °C water tank for 4 minutes. Then, based on the four-stage scale, the animals which showed seizure signs were divided into 4 groups. After this stage, ten pups from the groups, which had hyperthermia and seizure, were selected for further investigations. The animals which presented no seizure behaviors were taken as hyperthermia without seizure (n=10) group. To control the effects of environmental stress a sham-control group consisting 10 rats were also included in the study.
Results: A significant elevation in the animals' body temperature in all groups was observed in comparison to the sham controls (P<0.05).No mortality was seen in the sham-control, hyperthermia without seizure, and 1st seizure stage groups., But 10% in each of the 2nd and 3rd seizure stage groups and 30% in the 4th group were died. Duration of seizure in the groups II, III, and IV was 89.46, 121.57, and 198.49 seconds, respectively.
Conclusion: Hot water bath model seems to be an efficient method to induce febrile seizure in lab animals, and the interested researchers can consider it.
Animal model, Febrile seizure, Hyperthermia
http://journal.bums.ac.ir/article-1-1237-en.html
http://journal.bums.ac.ir/article-1-1237-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Effect of ethosucximide on the reduction of neuropathic pain due to chronic constriction of the sciatic nerve in rats
37
44
FA
Gholam Ali
Hamidi
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
hamidi_gh@kaums.ac.ir
Mahdi
Honarkar Ramezani
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
Meysam
Noorani Arani
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
Azhdar
Heydari
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
Hamid Reza
Banafshe
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran
banafshe57@gmail.com
Background and Aim: Neuropathic pain is caused by a lesion or disease of the peripheral or central nervous system. Since, treatment of neuropathic pains remains a challenge, the purpose of the present study was to examine the effect of ethosuximide, an anti-epileptic and relatively selective T-type calcium blocker, on the behavioral responses following chronic constriction pain (CCI) induced in rats.
Materials and Methods: Experiments were performed on six groups (n=8) of male Sprague-Dawley rats (230-280g). The groups consisted of the control group, induced chronic constriction of the sciatic nerve (CCI), 3 groups receiving ethosuximide with concentrations 100, 200, 300mg/kg, and one group which received normal saline. The cold-and mechano-allodynia and thermal hyperalgesia were measured prior to surgery (the day 0) and 3, 5, 7, 14 and 21 days postsurgery. Statistical analysis of repeated ANOVA was used to compare the results of behavioral tests by means of SPSS software (V: 16).
Results: It was found that the CCI group significantly produced mechanical and cold allodynia and a hypersensitivity to noxious stimulations. Ethosuximide significantly decreased cold and mechano-allodynia and thermal hyperalgesia.
Conclusion: Results suggested that the CCI model significantly influences behavioral responses to both the thermal and mechanical stimulations. Besides, systemic administration of ethosuximide significantly decreases behavioral responses of neuropathic pain induces through CCI. Thus, ethosuximide can be taken as a new potential therapeutic drug used against neuropathic pain.
Neuropathic pain, Allodynia, Hyperalgesia, Ethosuximide
http://journal.bums.ac.ir/article-1-1219-en.html
http://journal.bums.ac.ir/article-1-1219-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Application of adsorption process by activated carbon derived from scrap tires for Pb+2 removal from aqueous solutions
45
57
FA
Edris
Hoseinzadeh
department of environmental health engineering, Nutritional Health Research Center (NHRC), faculty of health, Lorestan University of Medical Sciences, Khorramabad, Iran edris-2009@live.com
hoseinzadeh@lums.ac.ir
Ali Reza
Rahmani
PhD of Environmental Health Engineering, Health Sciences Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
rahmani@umsha.ac.ir
Ghorban
Asgari
department of environmental health engineering, faculty of health, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohamad Taghi
Samadi
department of environmental health engineering, faculty of health , Hamadan University of Medical Sciences, Hamadan, Iran.
Ghodratollah
Roshanaei
faculty of health, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Reza
Zare
, Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
mzare@yahoo.com
Background and Aim: Heavy metals have been recognized as very poisonous elements and their discharge into water sources can cause damaging effects on human and environmental health. The present study aimed at producing activated carbon from scrap tires and using it in removing Pb+2 from synthetic aqueous solutions.
Materials and Methods: In this experimental study, activated carbon powder was derived from scrap tires under laboratory conditions. The effect of Pb (II) ions with the concentration 10-100mg/l, pH 2-8, contact time 3 hs , and the adsorbent dosage 0.1-0.6 g were investigated in batch adsorption system. Besides, the chemical composition and solid structure of the derived activated carbon were analyzed using Scanning Electron Microscopy (SEM) coupled with energy dispersive spectrometry (EDS). The surface area of derived activated carbon was calculated by Brunauer-Emmett-Teller (BET) and Barret-Joyner-Halenda (BJH) isotherms. The experimental data was analyzed using Langmuir and Freundlich isotherm models.
Results: It was found that the main component of activated carbon was Carbon element (83.276%). BET and BJH Surface areas of activated carbon were approximately 185.046 and 146.443 m2/g, respectively. It was discovered that activated carbon dosage increasing leads to decreasing in qmax , while with increasing of pH of Pb+2 ions adsorption increased. The experimental adsorption isotherm complied with Freundlich equation model (R2=0.982) and the maximum amount of adsorption (qmax) was 8.695 mg/g.
Conclusion: The present study showed that derived activated carbon from scrap tires is highly effective in Pb removal from aqueous solutions. In addition, producing activated carbon from scrap tire can provide a two-fold green and cost-effective advantage and it can be a suitable recycling method for scrap tires.
Aqueous solution, Adsorption, Pb (II), Activated derived carbon, Scrap tire
http://journal.bums.ac.ir/article-1-1329-en.html
http://journal.bums.ac.ir/article-1-1329-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Effect of sex education, based on the theory of planned behavior, on the sexual function of the woman attending Mashhad health centers
58
67
FA
Hossein
Ebrahimipour
department of health and management, school of public health, University of Medical Sciences, Mashhad, Iran
Zeinab
Jalambadany
, school of health, Mashhad University of Medical Sciences, Mashhad, Iran
jalambadaniz @gmail.com
Nooshin
Peyman
department of health and management, school of public health, University of Medical Sciences, Mashhad, Iran
Habibollah
Ismaili
department of biostatistics, school of public health, University of Medical Sciences, Mashhad, Iran
Ali
Vafaii Najjar
department of health and management, school of public health, University of Medical Sciences, Mashhad, Iran
Background and Aim: More than half of the sexual problems which cause family life abolishment and marital relationships are due to insufficient knowledge or erroneous beliefs about sexual relationships. Theory of Planned Behavior is one of the important theories that explains the main process of adopting health behaviors.
The present study investigated the effect of sex education, based on Theory of Planned Behavior, on the sexual function of married women referring to Mashhad healthcare centers (H.C.C).
Materials and Methods: In this Semi experimental study, 80 of women visiting 5 H.C.C of Mashhad were selected and assessed through semi-experimental method. The validity and reliability of the questionnaire used were determined through face and content validity and through Cronbach’s alpha and test-retest respectively. The obtained data was analyzed by SPSS software (V: 11.5) using statistical tests Spearman's correlation coefficient, and regression analysis.
Results: After educational intervention, the average rates of knowledge, attitude, perceived behavioral control and intention of sexual functioning in the sex education group significantly increased (P<0.05) the mentioned changes were not significant in the control group. Besides, a significant statistical difference was not observed in abstract norms between the two groups after intervention.
Conclusion: Regarding the effect of education in promoting women's sexual function, it is suggested that sexual function promotion workshops for couples should be held in health centers with the aim of preventing sexual problems.
Sex Education, Theory of Planned Behavior, Sexual Function
http://journal.bums.ac.ir/article-1-1236-en.html
http://journal.bums.ac.ir/article-1-1236-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Prevalence of breast cancer among women over 30 years in Birjand between 2009 and 2010
68
76
FA
fatemeh
haghighi
, department of pathology, faculty of medicine, Birjand University of Medical Sciences, Birjand, Iran
haghighifa@yahoo.com
mahyar
mohammadifard
, department of radiology, faculty of medicine , Birjand University of Medical Sciences, Birjand, Iran
ghodratollah
naseh
, department of cardiology, faculty of medicine, Birjand University of Medical Sciences, Birjand, Iran
katauon
hashem
, University of Medical Sciences, Mashhad, Iran
seyyed alireza
saadatjoo
, department of nursing, school of nursing and mdwifery, Birjand University of Medical Sciences, Birjand, Iran
s_saadatjoo@yahoo.com
Background and Aim: Cancer is the second leading cause of death in industrialized countries and the third in developing ones. The present study aimed at assessing prevalence of breast cancer among women over 30 in Birjand between 2009 and 2010.
Materials and Methods: In this descriptive-analytical study, 2000 over 30 years women from Birjand city were selected through multiple-stage sampling. A demographic questionnaire was completed by each subject after being justified about the importance of screening and method of examination. Clinical breast examination was performed by a female GP under standard conditions, one week after menstrual ceasing. When there was a palpable mass in the breast, the participant underwent a mammography test for an accurate diagnosis of the type and size of the lesion. Positive cases were referred to a surgeon for open biopsy. The obtained data was analyzed by means of SPSS software (V: 15) using ANOVA test at α = 0.05 as the significance level.
Results: Out of 2000 surveyed women, 80 were excluded because of the inappropriateness of their completed questionnaires. Totally, 1920 women were included with the mean age of 44.48±8.56 (range: 30-88) years. Out of 267 women (13.9%) referred for mammography due to positive clinical findings, only 134 (50.2%) cases underwent mammography test and 17 of them (12.7%) had a lesion as observed in their mammography images and, as a result, fibrocystic lesion was the most common diagnosis. Biopsy was performed for 32 patients (1.6% of the total participants) and malignancy was reported in 11 patients (0.5%). Mean age of the cancer patients was 41.18±12.65 years which was similar to other women's situation without malignancy (P=0.11).
Conclusion: According to our results and based on the low mean age of patients with breast cancer, it is required to study the causes leading to the early occurrence of breast cancer at young ages in this area.
Breast Cancer, Prevalence, Screening, Mammography
http://journal.bums.ac.ir/article-1-1312-en.html
http://journal.bums.ac.ir/article-1-1312-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Prevalence of malnutrition in under 5-year old children in Birjand city in 2011
77
84
FA
azita
fesharakinia
Board certified in Pediatric nephrology, Birjand University of Medical Sciences, Birjand, Iran.
fesharakinia@yahoo.com
gholamreza
sharifzadeh
member of The Research Center of Effective Social Factors on Health, Health department, Birjand University of Medical Sciences, Birjand, Iran
Background and Aim: Malnutrition of children, which has undesirable effects on mental and physical health of them, is one of the important health problems throughout the world particularly in developing countries. Most of the studies about malnutrition in Iran have been done on the basis of NCHS standards, but, today it is recommended to do this kind of study according to new WHO standards. The aim of this study was to find out prevalence of malnutrition in under-5 year olds in Birjand city according to the recent standards.
Materials and Methods: This cross-sectional and descriptive study was done on 480 under-5 year olds that selected through multistage cluster sampling method in Birjand city in 2011.At the same time of measuring height and weight, demographic data of the children (age, sex, birth order , and birth weight) were recorded in the questionnaires by interviewing their mothers .In order to study malnutrition ,three indices were used namely weight to age (underweight), weight to height (leanness), and height to age(shortness). The obtained data was analyzed by means of descriptive statistical methods and chi-square test, using SPSS software (V:15) , and a=0.05 was taken as the significant level.
Results: Out of 480 children 50.4% were males, 93.3% had birth weight ≥2500 gr, 56% were above 24 months. 57.7% were the first in birth order. According to the new WHO standards, Weight index showed that 93.7% were normal and 6.3% were underweight (5% moderately and 1.3% severely). Regarding stunting criteria, 90.2% were normal and 9/8 % were short (7.7% moderately and 2.1% extremely short). Prevalence of underweight and stunting was significantly higher in children with birth weight under 2500 gr (P<0.001). Wasting criteria showed that 99.2% were normal and 0.8% had moderate wasting.
Conclusion: According to the results and comparing them with those of similar studies, it is concluded that the nutritional status of under 5 year children in Birjand is appropriate. Regarding the significant relationship of underweight and stunting with low birth weight, more control on high risk pregnancy for reducing the rate of low birth weight infants and supportive nutritional and educational measures for these children are recommended.
Underweight, Leanness, Shortness, Under- 5 children, Malnutrition, Prevalence, New standards of WHO
http://journal.bums.ac.ir/article-1-1251-en.html
http://journal.bums.ac.ir/article-1-1251-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Abstract: Evaluation of heavy metals (Cd, Cr, Zn, Pb) concentration in effluent & sludge of a tile factory in Birjand 2011
85
93
FA
mohammad hamed
hosseini
Department of Public Health, School of Public Health, Birjand University of Medical Sciences, Iran.
maryam
khodadadi
Department of Public Health, School of Public Health, Birjand University of Medical Sciences, Iran
maryam.khodadadi@gmail.com
hadighe
dorri
School of Public Health, Birjand University of Medical Sciences, Birjand, Iran
Background and Aim: Sewage of non-metallic and mineral industrials such as tile and ceramic contain a large amount of heavy metals (e.g. Zn, Cr, Cd, Pb) and minerals which can cause problems such as contaminating underground water and polluting the environment. Thus, the present study was done to evaluate heavy metals concentration in the effluent and sludge of the tile factory in Birjand.
Materials and Methods: In this descriptive analytical study, 36 samples were taken from six pools in June 2010 (18 samples from the effluent and 18 samples from the sludge). Analysis of the rate of the heavy metals in the samples was done on the basis of the procedures mentioned in 3010 Standard Method book.
Results: It was found that mean concentration of the heavy metals Zn, Cr, Cd, and Pb in the effluent samples was 0.135±0.235, 0.21±0.022 , 0 ,and 0.064± 0.017 mg/l respectively. These concentration levels were less than permissible standards of the Iranian Environmental Protection Agency. But, in sludge deposited on the bottom ponds, concentration of the heavy metals Zn, Cr, Cd, Pb was 3160±278.15, 1493.52±352.95, 22.18±17./55 , and 1139.11±737.5 mg/kg respectively. That is, the concentrations of Cd and Zn were less than those in the American EPA Standards, but Pb and Cr concentrations were more than EPA Standards to permit the use of sludge in the land.
Conclusion: It was revealed that in the effluent of tile and ceramic industries heavy metals concentrations are higher than environmental standards, which require more supervision and surveillance of the environmental agencies.
Heavy metals, Effluent, Sludge, Tile factory
http://journal.bums.ac.ir/article-1-1174-en.html
http://journal.bums.ac.ir/article-1-1174-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
Factors influencing the status of appropriate and inappropriate shocks delivered by an implantable cardioverter defibrillator
94
101
FA
Vahid
Ghavami Ghanbarabadi
Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran
ghavamighv1@mums.ac.ir
Jamshid
Jamali
Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
jamalij2@mums.ac.ir
Alireza
Heidari-Bakavoli
Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Bakavoli871@mums.ac.ir
Mohammad
Tayyebi
Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
NazariHH841@mums.ac.ir
Hossein
Nazari Hyanlo
Mashhad University of Medical Sciences, Mashhad University of Medical Science, Mashhad, Iran
Tayyebim@mums.ac.ir
Mohammad Taghi
Shakeri
Department of Biostatistics, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
shakerimt@mums.ac.ir
Background and Aim: The QRS duration is a strong predictor of mortality, particularly in heart failure patients. However, studies on the usefulness of QRS duration, as a predictor of ventricular arrhythmic events in ICD patients, have proved to be contradictory. Since in patients with implantable cardioverter defibrillator (ICD), all of the malignant ventricular arrhythmias are recorded and treated with appropriate shock (i.e. appropriate shock and inappropriate shock), in the present study the relationship between the QRS duration and status of appropriate or inappropriate ICD shocks was evaluated.
Materials and Methods: In this cross-sectional study 65 patients with implanted cardioverter defibrillator were included to prevent their undue death. Before the implantation, QRS duration in the surface ECG was measured and recorded. Furthermore, variables such as age, gender, indication for ICD implantation, family history of sudden cardiac death, and QTc interval before ICD implantation were recorded. During follow-up visits of the patients, ICDs were interrogated and appropriate and inappropriate therapies were traced. Finally logistic regression in SPSS statistical software (V: 11.5) was used for data analysis.
Results: Mean age of the patients was 17.208±47.92 years. Eighteen patients (27.7%) were females and 58 (89.2%) had a family history of sudden cardiac death. Mean QRS duration and QTc interval were 36.78 ± 117.94 msec and 62.42±466.97 msec, respectively. There was no statistically significant relationship between QRS duration and status of appropriate and inappropriate ICD shocks. Among the studied parameters, there was only a significant relationship between status of appropriate or inappropriate ICD shocks and the different manufacturers of ICD devices.
Conclusion: QRS duration does not have a significant relationship with status of appropriate and inappropriate ICD shocks. This may not predict arrhythmic events in ICD patients.
Appropriate therapy, Inappropriate therapy, QRS duration, QTc duration, Heart failure, ICD
http://journal.bums.ac.ir/article-1-1242-en.html
http://journal.bums.ac.ir/article-1-1242-en.pdf
Birjand University of Medical Sciences
Journal of Birjand University of Medical Sciences
1607-2197
2423-6152
20
1
2013
5
1
A Case report of Wolfram Syndrome
102
107
FA
Samaneh
Norooziasl
Department of Pediatrics, Hospital Vali-e-Asr, Birjand University of Medical Sciences, Birjand, Iran
samaneh.norooziasl@yahoo.com
Seyed Alireza
Javadinia
Member of Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
sar.javadinia@bums.ac.ir
Wolfram Syndrome is a neurodegenerative autosomal recessive disorder. The occurrence of the disease should be suspected if non-autoimmune insulin-dependent diabetes occurs in an under-sixteen year old person having bilateral optic nerve atrophy. Diabetes insipidus (DI), neurosensory deafness, urinary track disorders, and nervous system complications are also seen in this disorder. The current report presents a 13-year-old female patient with diabetes mellitus type I (since age 4) along with recurrent urinary infection and enuresis and progressive renal failure (since age 10). Bilateral optic atrophy was evident on fondues examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, short stature, combined with delayed sexual maturity.
Wolfram Syndrome, Diabetes mellitus, Neurosensory deafness,
http://journal.bums.ac.ir/article-1-1321-en.html
http://journal.bums.ac.ir/article-1-1321-en.pdf