Volume 19, Number 2 (July 2012)                   J Birjand Univ Med Sci. 2012, 19(2): 165-172 | Back to browse issues page


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Hosseini S E, Karimzadeh K. Anti-diabetic effects of hydroalcohlic juglans regia male flower extract on blood glucose level and on liver enzymes activity in intact and diabetogenized adult male rat. J Birjand Univ Med Sci.. 2012; 19 (2) :165-172
URL: http://journal.bums.ac.ir/article-1-972-en.html

1- Assistant professor fars science and research branch Islamic Azad University, Fars, Iran , ebrahim.hossini@yahoo.com
2- - fars science and research branch Islamic Azad University, Fars, Iran
Abstract:   (15039 Views)

  Background and Aim: Diabetes is a metabolic disorder resulting from defects in insulin secretion or function. Walnut is a nutrient used in traditional medicine to treat diabetes. In the current study, anti-diabetic effects of the Hydroalcoholic extract of walnut male flowers on diabetogenized rats by using Streptozocin were evaluated.

  Materials and Methods: Seventy two adult male Wistar rats weighing 200-225 g each were randomly selected and divided into three main groups, i.e. control, diabetic, and non-diabetic(intact) The control group included 8 rats (n=8). The diabetic and non-diabetic groups covered 32 rats each. Each of these groups were divided into four 8 rats including the control, diabetic, experimental 1, 2, and 3 which received 2, 4, or 6 g/kg of the extract per day for 15 days ,respectively. The three diabetic groups were each treated with the above doses of the extract, and the fourth group received no treatment. Diabetes was induced in diabetic rats through intraperitoneal injection of 60 mg/kg of Streptozotocin. At the end, blood samples were taken from the experimental and control groups and the serum levels of insulin and glucose were measured.

  Results: A significant reduction in blood sugar and increase of insulin in diabetics receiving Hydroalcoholic extract of male flowers walnut was observed compared with non-diabetic ones.

  Conclusion: Hydroalcoholic extract of male Walnut flowers, due to increasing insulin, causes reduction of blood sugar.

Full-Text [PDF 235 kb]   (2157 Downloads)    
Type of Study: Original Article | Subject: Physiology
Received: 2011/11/6 | Accepted: 2012/05/29 | Published: 2016/03/10

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