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Nazari T, Eazad Yar S. Survey of endometrial hyperplasia frequency and it’s risk factors in 40-60 year old patients who referred to Yahyanezhad hospital in Babol (2000-2003). J Birjand Univ Med Sci. 2006; 13 (2) :9-15
URL: http://journal.bums.ac.ir/article-1-92-en.html

Background and Aim: Endometrial hyperplasia is the overgrowth of endometrial glands due to prolonged unopposed estrogenic stimulation. Its major clinical symptom is abnormal uterine bleeding (especially perimenopausal). The disease has several risk factors. The aim of this study was to assess the prevalence of endometrial hyperplasia and its risk factors in perimenopausal period in women who referred to Yahyanezhad educational and therapeutic center because of Abnormal Uterine Bleeding (AUB) between 2000 and 2003.
Materials and Methods: In this descriptive- analytic (cross- sectional) study, we surveyed the records of perimenopausal patients (40-60 years) referring to Yahyanezhad hospital, affiliated to Babol University of Medical Sciences, for having AUB between 2000 and 2003. Information regarding age, diabetes melitus (DM), hypertension, hormone therapy, endometrial hyerplasiabased on pathology specimen for every patient was gathered .The data were then analysed by SPSS -10 software using Fisher exact test at the significant level of P≤ 0.05.
Results: A total of 366 perimenopausal AUB records were studied. Of these, 73 cases had endometrial hyperpalsia. Relative abundance of hyperplasia was about 19.9% in the studied population. Also, it was found that the studied risk factors including aging, DM, hypertension, and estrogen hormone replacement therapy increase the risk of endometrial hyperplasia. In none of the cases there was a significant relationship between endometrial hyperplasia and the risk factors, but taking oral contraceptive pills (OCP) had significantly decreased hyperplasia (P<0.05 ).
Conclusion: Endometrial hyperplasia in the studied region had a high frequency. DM, hypertension, old age, and history of hormone replacement therapy were not diagnosed as major risk factors of the disorder, but OCP was found to have preventive effect.