Volume 12, Issue 1 And 2 (April & July 2005)                   J Birjand Univ Med Sci. 2005, 12(1 And 2): 9-15 | Back to browse issues page

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Balali-Mood M, Ahmadi A, Balali-Mood K, Ghafghazi T, Rajabi P, Taher M. Toxicity evaluation of an antitumor marine compound (HESA-A) in mice and rats. J Birjand Univ Med Sci.. 2005; 12 (1 and 2) :9-15
URL: http://journal.bums.ac.ir/article-1-36-en.html
1- Professor and Director, Medical Toxicology Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran , mbalalimood@hotmail.com
2- Research Physician, Cancer Research Institute, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- Post- Doctoral Researcher, Department of Biochemistry, Faculty of Medicine, Oxford University, England
4- Professor, Department of Pharmacology, Faculty of Pharmacy, Isfahan University of Medical Sciences. Isfahan, Iran
5- Professor, Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences. Isfahan, Iran
6- Assistant Professor, Department of Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences. Isfahan, Iran
Abstract:   (10350 Views)
Background and Aim: HESA-A is a marine biological compound that was recently patented in the Islamic Republic of Iran, revealed anti-tumor properties in-vitro and in-vivo. The objective of this study was to investigate the acute, sub-acute, and chronic toxicity of HESA-A in mice and rats.
Materials and Methods: The acute toxicity testing of HESA-A (0.5-18 g/kg) orally in different groups of mice and rats were undertaken. Sub-acute toxicity testing of the drug (10 g/kg/day for a week) on rats and chronic toxicity testing of different doses of HESA-A (1.25-5.00 g/kg/day for 30 days) on different groups of mice were carried out. Clinical abnormalities, changes in body temperature and weight, biochemical, haematological and pathological investigations were recorded.
Results: Acute toxic effects of HESA-A occurred after 10 g/kg and the LD50s were calculated as 16 g/kg and 18 g/kg for mice and rats, respectively. The body weight of rats taken 18 g/kg of HESA-A reduced significantly (P<0.05) at day 14 and after death. Sub-acute and chronic toxic effects of HESA-A in rats and mice were observed only in a few rats and in the mice taken 5 g/kg/day of the drug for 30 days. Drowsiness,
vomiting, diarrhoea and convulsions were the common findings. The body weight of rats decreased significantly (P<0.05) from 200±21 g to 156±22 g at day 14. In few rats and in the group of mice that received 5 g/kg HESA-A daily for 30 days, mild infiltration of lymphocytes in the liver tissues were
observed.
Conclusion: Based on the results, HESA-A has very little toxic effect on mice and rats.
Keywords: Toxicity, Acute, Chronic, Drug, HESA-A
Full-Text [PDF 210 kb]   (1820 Downloads)    
Type of Study: Original Article | Subject: Toxicology
Received: 2006/09/6 | Accepted: 2016/03/10 | Published: 2016/03/10

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