Volume 29, Issue 1 (April 2022)                   J Birjand Univ Med Sci 2022, 29(1): 42-49 | Back to browse issues page

Research code: IR.IAU.KAU.REC.1396.128
Ethics code: IR.IAU.KAU.REC.1396.128


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Ghavami M, Shariati M, Moghadamnia D. Protective effects of hydroalcoholic extract of Alcea rosea aerial parts on cadmium chloride-induced renal dysfunction in male rats. J Birjand Univ Med Sci 2022; 29 (1) :42-49
URL: http://journal.bums.ac.ir/article-1-3132-en.html
1- Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran , davood.moghadamnia@gmail.com
Abstract:   (1118 Views)
Background and Aims: Cadmium chloride causes renal dysfunction. The present study aimed to investigate the protective effects of hydroalcoholic extract of Alcea rosea aerial parts on cadmium chloride-induced renal dysfunction in male rats.
Materials and Methods: In this experimental study, 54 adult male Wistar rats were assigned to six groups (n=9 in each group). The control group, the sham group1, received 0.2 ml of distilled water as solvent. Sham group 2 received 2 mg/kg cadmium chloride intraperitoneally (IP) for 21 days. Experimental groups 1, 2, and 3, respectively, received 2 mg/kg cadmium chloride IP for 21 days, followed by 150,300, and 450 mg/kg hydroalcoholic extracts of aerial parts of Alcea rosea intraperitoneally for 30 days. At the end of the experiment, blood samples were taken from all animals to measure levels of sodium, potassium, blood urea nitrogen (BUN), creatinine, and uric acid. The data were analyzed in SPSS software (version 18) using one-way ANOVA and Tukey post hoc test.
Results: The mean serum concentrations of creatinine, BUN, sodium, potassium, and uric acid in all experimental groups showed a significant decrease, as compared to those in sham group 2 (P<0.05).
Conclusion: Based on the results, hydroalcoholic extract of aerial parts of Alcea rosea may improve cadmium chloride-induced renal dysfunction in male rats.
Full-Text [PDF 618 kb]   (302 Downloads)    
Type of Study: Original Article | Subject: Renal Physiology
Received: 2022/02/16 | Accepted: 2022/03/14 | ePublished ahead of print: 2022/04/6 | ePublished: 2022/04/4

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